Association of the Systemic Immune-Inflammation Index with Outcomes in Acute Coronary Syndrome Patients with Chronic Kidney Disease

Shi, Sanling; Kong, Shuting; Ni, Weicheng; Lu, Yucheng; Li, Junfeng; Huang, Yuexiang; Chen, Jinxin; Kang, Lin; Li, Yuanmiao; Ke, Jiayu; Zhou, Hao

doi:10.2147/jir.s397615

Cited by 14 publications

(11 citation statements)

References 58 publications

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“…Table 1 presents a comprehensive overview of the detailed characteristics of the studies incorporated in the meta‐analyses 10,20–27 . Among the selected studies, six were conducted in Asia, while three were conducted in Europe.…”

Section: Resultsmentioning

confidence: 99%

Prognostic value of systemic immune‐inflammation index in CAD patients: Systematic review and meta‐analyses

Zhao,

Zhang,

Sun

et al. 2023

Eur J Clin Investigation

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BackgroundSystemic immune‐inflammation index (SII) is a novel inflammatory marker based on neutrophils, platelets and lymphocytes counts, which has potential prognostic value among coronary artery disease (CAD) patients as described by some observational studies. We aimed to provide higher‐certainty evidence to verify the association of SII with poor outcomes of CAD patients.MethodsPubMed, Web of Science, Embase, Ovid and Scopus were searched to find relevant literature exploring the prognostic value of SII among CAD patients. Hazard ratios (HRs) with 95% confidence intervals (CIs) extracted from the literature included were pooled with the fixed‐effect or random‐effect model. Sensitivity analyses and subgroup analyses were conducted to detect the source of heterogeneity and evaluate the stability of results.ResultsA total of nine studies with 15,832 participants were included. The quantitative synthesis including eight studies with 15,657 participants showed that the high SII was related to the major adverse cardiovascular event in CAD patients (HR with 95% CI: 2.36 [1.67, 3.33]). After eliminating heterogeneity and adjusting for publication bias, the above result was still robust (HR with 95% CI: 1.67 [1.32, 2.12]). Additionally, we also demonstrated the prognostic values of SII for all‐cause death, cardiovascular death, myocardial infarction and stroke.ConclusionHigher SII has prognostic values for adverse outcomes in CAD patients.

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Section: Resultsmentioning

confidence: 99%

Prognostic value of systemic immune‐inflammation index in CAD patients: Systematic review and meta‐analyses

Zhao,

Zhang,

Sun

et al. 2023

Eur J Clin Investigation

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“…A cohort study was conducted by Halpern et al in one center. Regarding prognosis, prospective cohort research by Shi [ 31 ] et al showed that in CKD patients with ACS, higher SII was linked to poor cardiovascular outcomes. In a similar vein, Xie et al [ 41 ] discovered a favorable correlation between SII and abdominal aortic calcification, a frequent CKD consequence.…”

Section: Discussionmentioning

confidence: 99%

“…This study additionally included covariates in the analysis to account for the possible impact of other variables on bone metabolism. Age, race, body mass index (BMI), smoking, hypertension, diabetes mellitus, blood alkaline phosphatase, serum uric acid, blood calcium, blood phosphorus, blood vitamin D, and blood triglycerides were eventually added as covariates based on other research [ 31 , 32 ]. In this instance, the final blood pressure reading was calculated as the average of the body measures, and hypertension was defined as a mean systolic blood pressure of greater than 140 mmHg and/or a mean diastolic blood pressure of greater than 90 mmHg.…”

Section: Methodsmentioning

confidence: 99%

Systemic immune-inflammatory indicators and bone mineral density in chronic kidney disease patients: A cross-sectional research from NHANES 2011 to 2018

Jiang,

Bao

2024

PLoS ONE

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Background The purpose of this study was to look at the relationship between the Systemic Immune Inflammatory Index (SII) and bone mineral density (BMD) in the pelvis, left upper and lower limbs, lumbar spine, thoracic spine, and trunk in a chronic kidney disease (CKD) population in the United States. Methods The National Health and Nutrition Examination Survey (2011–2016) yielded 2302 people with CKD aged >18 years. CKD was defined as eGFR less than 90 ml/min/1.73 m2 or eGFR greater than 90 ml/min/1.73 m2 with urine ACR greater than 30 mg/L.SII was calculated as PC * (NC / LC) from platelet count (PC), neutrophil count (NC), and lymphocyte count (LC). Multiple logistic regression was used to examine the relationship between BMD and SII at different sites in CKD patients, smoothed curve-fitting and generalized weighting models were used to investigate non-linear relationships, and a two-tailed linear regression model was used to find potential inflection points in the model. Results We discovered a negative correlation between SII and pelvic BMD among 2302 participants after controlling for gender, age, and race [β = -0.008; 95% confidence value -0.008; 95% confidence interval (CI) -0.014, -0.002]. Lower PEBMD was related to increasing SII (trend p = 0.01125). After additional correction, only pelvic BMD remained adversely linked with SII [value -0.006; 95% CI -0.012, -0.000, p = 0.03368]. Smoothed curve fitting revealed a consistent inverse relationship between SII and pelvic BMD. Further stratified analyses revealed a substantial positive negative connection between SII and pelvic BMD in individuals who did not have hypertension, diabetes, a BMI of more than 30 kg/m2, or stage 2 CKD. The connection between SII and PEBMD in people without diabetes revealed a strong inverted U-shaped curve. Conclusion In individuals with CKD in the United States, there was a negative connection between the systemic immunoinflammatory index (SII) and pelvic BMD. The SII might be a low-cost and simple test for CKD-related BMD loss.

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“… 12 , 21 SII has also been described as a predictor of poor clinical prognosis in ACS patients with chronic kidney disease. 22 During a 10-year follow-up study, SIRI was associated with incident CAD and an increased risk of all-cause death and stroke but not MI. 23 Similarly, higher SIRI was associated with more severe disease status in patients with ACS undergoing PCI, and the predictive value was synergistically increased when combined with the GRACE risk score.…”

Section: Introductionmentioning

confidence: 99%

The Systemic Immune Inflammatory Response Index Can Predict the Clinical Prognosis of Patients with Initially Diagnosed Coronary Artery Disease

Li,

Bai,

Gao

et al. 2023

JIR

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Background Recently, the systemic immune inflammatory response index (SIIRI), a novel and expanded inflammatory response marker, has been an independent predictor of lesion severity in patients with acute coronary syndrome (ACS). However, its predictive role in patients with initially diagnosed coronary artery disease (CAD) remains to be explored. Patients and Methods We evaluated 959 patients with CAD undergoing an initial coronary intervention. Each patient had laboratory measurements, including blood cell counts, taken after admission and before interventional treatment. The primary endpoint was major cardiovascular events (MACEs), defined as cardiovascular death, nonfatal myocardial infarction(MI), and nonfatal stroke. The secondary endpoints included MACEs and readmission for congestive heart failure(HF). Results During a mean follow-up period of 33.3±9.9 months, 229 (23.9%) MACEs were recorded. ROC curve analysis displayed that the best cut-off value of SIIRI for predicting MACEs was 247.17*10 18 /L 2 . Kaplan-Meier survival curve analysis showed that the survival rate of the low SIIRI group was higher than that of the high SIIRI group (P<0.001). Compared with the low SIIRI group, the high SIIRI group had a significantly higher risk of MACEs (187 cases (39.53%) vs.42 patients (8.64%), P<0.001). Univariate and multivariate Cox regression analyses displayed that high SIIRI levels were independently associated with the occurrence of MACEs in patients with initially diagnosed CAD undergoing percutaneous coronary intervention (PCI) (adjusted hazard ratio [HR]: 3.808, 95% confidence interval [CI%]: 2.643–5.486, P<0.001). Adding SIIRI to conventional risk factor models improved the predictive value of MACEs. Conclusion Elevated SIIRI is associated with adverse cardiovascular prognosis in patients with initially diagnosed CAD. SIIRI can be a simple and practical index to identify high-risk patients with CAD after PCI.

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Association of the Systemic Immune-Inflammation Index with Outcomes in Acute Coronary Syndrome Patients with Chronic Kidney Disease

Cited by 14 publications

References 58 publications

Prognostic value of systemic immune‐inflammation index in CAD patients: Systematic review and meta‐analyses

Prognostic value of systemic immune‐inflammation index in CAD patients: Systematic review and meta‐analyses

Systemic immune-inflammatory indicators and bone mineral density in chronic kidney disease patients: A cross-sectional research from NHANES 2011 to 2018

The Systemic Immune Inflammatory Response Index Can Predict the Clinical Prognosis of Patients with Initially Diagnosed Coronary Artery Disease

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