Association of the rs11196218 polymorphism in TCF7L2 with type 2 diabetes mellitus in Asian population

Zhai, Yujia; Zhao, Jiupeng; You, Haisheng; Pang, Chao; Li, Yin; Guo, Tao; Feng, Ting; Wang, Chongjian; Gao, Kaiping; Luo, Xinping; Zhang, Ming; Wang, Jinjin; Li, Linlin; Wang, Bingyuan; Ren, Yongcheng; Shen, Yi; Zhu, Tiejun; Hu, Dongsheng

doi:10.1016/j.mgene.2014.04.006

Cited by 16 publications

(14 citation statements)

References 21 publications

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“…Qian et al (2015) conducted a quantitative trait analysis and showed that the AC genotype of rs1552224 presented higher FBG than the AA/CC genotypes in a control population with normal glucose. Mechanistic studies suggest that TCF7L2 can impair β-cell function, and down regulate the expression levels of glucagon-like peptide 1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIP-R), thereby reducing insulin levels (Zhai et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

Quantitative candidate gene association studies of metabolic traits in Han Chinese type 2 diabetes patients

Wei¹,

Cai²,

Yu³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Recent genome-wide association studies have identified many loci associated with type 2 diabetes mellitus (T2DM), hyperuricemia, and obesity in various ethnic populations. However, quantitative traits have been less well investigated in Han Chinese T2DM populations. We investigated the association between candidate gene single nucleotide polymorphisms (SNPs) and metabolic syndromerelated quantitative traits in Han Chinese T2DM subjects. Unrelated Han Chinese T2DM patients (1975) were recruited. Eighty-six SNPs were genotyped and tested for association with quantitative traits including lipid profiles, blood pressure, body mass index (BMI), serum uric acid (SUA), glycated hemoglobin (HbA1c), plasma glucose [fasting plasma glucose (FPG)], plasma glucose 120 min post-OGTT (P2PG; OGTT = oral glucose tolerance test), and insulin resistance-related traits. We found that CAMTA1, ABI2, VHL, KAT2B, PKHD1, ESR1, TOX, SLC30A8, SFI1, and MYH9 polymorphisms were associated with HbA1c, FPG, and/or P2PG; GCK, HHEX, TCF7L2, KCNQ1, and TBX5 polymorphisms were associated with insulin resistance-related traits; ABCG2, SLC2A9, and PKHD1 polymorphisms were associated with SUA; CAMTA1, VHL, KAT2B, PON1, NUB1, SLITRK5, SMAD3, FTO, FANCA, and PCSK2 polymorphisms were associated with blood lipid traits; CAMTA1, SPAG16, TOX, KCNQ1, ACACB, and MYH9 polymorphisms were associated with blood pressure; and UBE2E3, SPAG16, SLC2A9, CDKAL1, CDKN2A/B, TCF7L2, SMAD3, and PNPLA3 polymorphisms were associated with BMI (all P values <0.05). Some of the candidate genes were associated with metabolic and anthropometric traits in T2DM in Han Chinese. Although none of these associations reached genomewide significance (P < 5 x 10 -8 ), genes and loci identified in this study are worthy of further replication and investigation.

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Section: Resultsmentioning

confidence: 99%

Quantitative candidate gene association studies of metabolic traits in Han Chinese type 2 diabetes patients

Wei¹,

Cai²,

Yu³

et al. 2015

Genet. Mol. Res.

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“…In total, 295 articles were relevant to our search terms, of which 285 papers were excluded. Thus, 10 case-control studies 15 – 19 , 30 – 34 comprising 7,491 cases of T2DM and 12,968 controls were ultimately included in this meta-analysis ( Figure 1 ). All of these studies were published from 2007-2014.…”

Section: Resultsmentioning

confidence: 99%

“…Nevertheless, the results regarding the rs11196218A/G polymorphism and T2DM risk have been inconsistent for the Chinese Han population. Certain studies 15 – 19 confirmed that the G allele of the rs11196218A/G polymorphism was significantly associated with T2DM risk, whereas studies by Ma 30 , Zheng et al 31 , Luo et al 32 , Wen et al 33 and Qiao et al 34 did not find a significant association between the rs11196218A/G polymorphism and T2DM risk in the Chinese Han population. Therefore, to resolve the conflict among these studies, we performed a meta-analysis to assess the association between the rs11196218A/G polymorphism and T2DM risk.…”

Section: Discussionmentioning

confidence: 97%

“…The transcription factor 7-like 2 (TCF7L2) gene, located on chromosome 10q25 2 , is part of the Wnt signaling pathway 3 and has been shown to be strongly associated with an increased risk of T2DM in Icelandic 4 , European 5 – 11 , West African 12 , southern Asian 13 , eastern Asian 14 , and Chinese 15 – 19 populations. The TCF7L2 gene is regarded as one of the most important genes for determining genetic susceptibility to T2DM that has been identified in humans so far.…”

Section: Introductionmentioning

confidence: 99%

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The association between the rs11196218A/G polymorphism of the TCF7L2 gene and type 2 diabetes in the Chinese Han population: a meta-analysis

Ma¹,

Wang²,

Guo³

et al. 2015

Clinics

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Transcription factor 7-like 2 has been shown to be associated with type 2 diabetes mellitus in multiple ethnic groups in recent years. In the Chinese Han population in particular, numerous studies have evaluated the association between the rs11196218A/G polymorphism of the transcription factor 7-like 2 gene and type 2 diabetes mellitus. However, the results have been inconsistent, so we performed a meta-analysis to assess the association. Odds ratio and 95% confidence interval values were calculated using a random-effects model or a fixed-effects model based on heterogeneity analysis. The quality of the included studies was evaluated using the Newcastle-Ottawa Scale. Subgroup analyses were conducted based on conformity with Hardy-Weinberg equilibrium in the control group as well as on other variables, such as age, sex and body mass index. Sensitivity analysis was also performed to detect heterogeneity and to assess the stability of the results. In total, 10 case-control studies comprising 7,491 cases and 12,968 controls were included in this meta-analysis. The combined analysis indicated that the rs11196218A/G polymorphism was not associated with type 2 diabetes mellitus (G vs. A, OR=1.04, 95% CI=0.97-1.13, p=0.28). The subgroup analyses also did not show any association between the rs11196218A/G polymorphism and the risk of type 2 diabetes mellitus. Furthermore, the results of the subgroup analyses indicated that the absence of an association was not influenced by age, sex or body mass index. The results of the sensitivity analysis verified the reliability and stability of this meta-analysis. In conclusion, this study indicated that there is no significant association between the rs11196218A/G polymorphism and the risk of type 2 diabetes mellitus in the Chinese Han population.

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“…T2DM is a complex disease and both genetic, and environmental factors appear to contribute to its development. [ 8 9 10 ]…”

Section: Introductionmentioning

confidence: 99%

Assay method for quality control and stability studies of a new anti-diabetic and anti-dyslipidemic flavone (S002-853)FNx01

et al. 2015

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Background:Flavonoid-rich extract of the plant is long known for its anti-diabetic activities in traditional medicine. S002-853, a new flavone derivative synthesized by Central Drug Research Institute (CDRI) has been used for the present study.Objectives:The present study aimed at development of an assay method for quality control (QC) and stability studies of a new anti-diabetic and anti-dyslipidemic agent CDRI compound S002-853.Materials and Methods:A validated high-performance liquid chromatography analysis method for S002-853 was developed for in process QC and stability studies. The separation was achieved on a RP-C18 (25 cm × 0.4 cm, 5 μm, Phenomenex) at 240 nm with flow rate of 1.0 ml/min. This method was applied successfully in establishing forced degradation and drug-excipient testing protocols as per International Conference on Harmonization guidelines.Results:The result of estimation and stress testing studies indicated a high degree of selectivity of this method. S002-853 was most stable at pH 7 and under photolytic conditions. The temperature degradation pattern of S002-853 was found to follow the zero order degradation.Conclusion:The method described is easy and simple hence can be easily reproduced. This method can be very useful for bulk manufacture QC, and drug development process.

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Association of the rs11196218 polymorphism in TCF7L2 with type 2 diabetes mellitus in Asian population

Cited by 16 publications

References 21 publications

Quantitative candidate gene association studies of metabolic traits in Han Chinese type 2 diabetes patients

Quantitative candidate gene association studies of metabolic traits in Han Chinese type 2 diabetes patients

The association between the rs11196218A/G polymorphism of the TCF7L2 gene and type 2 diabetes in the Chinese Han population: a meta-analysis

Assay method for quality control and stability studies of a new anti-diabetic and anti-dyslipidemic flavone (S002-853)FNx01

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