The association between the rs11196218A/G polymorphism of the TCF7L2 gene and type 2 diabetes in the Chinese Han population: a meta-analysis

Abstract

Transcription factor 7-like 2 has been shown to be associated with type 2 diabetes mellitus in multiple ethnic groups in recent years. In the Chinese Han population in particular, numerous studies have evaluated the association between the rs11196218A/G polymorphism of the transcription factor 7-like 2 gene and type 2 diabetes mellitus. However, the results have been inconsistent, so we performed a meta-analysis to assess the association. Odds ratio and 95% confidence interval values were calculated using a random-effects model or a fixed-effects model based on heterogeneity analysis. The quality of the included studies was evaluated using the Newcastle-Ottawa Scale. Subgroup analyses were conducted based on conformity with Hardy-Weinberg equilibrium in the control group as well as on other variables, such as age, sex and body mass index. Sensitivity analysis was also performed to detect heterogeneity and to assess the stability of the results. In total, 10 case-control studies comprising 7,491 cases and 12,968 controls were included in this meta-analysis. The combined analysis indicated that the rs11196218A/G polymorphism was not associated with type 2 diabetes mellitus (G vs. A, OR=1.04, 95% CI=0.97-1.13, p=0.28). The subgroup analyses also did not show any association between the rs11196218A/G polymorphism and the risk of type 2 diabetes mellitus. Furthermore, the results of the subgroup analyses indicated that the absence of an association was not influenced by age, sex or body mass index. The results of the sensitivity analysis verified the reliability and stability of this meta-analysis. In conclusion, this study indicated that there is no significant association between the rs11196218A/G polymorphism and the risk of type 2 diabetes mellitus in the Chinese Han population.

Smoking increases the risk of diabetic foot amputation: A meta-analysis

“…Table I indicates the basic information of the studies involved in the meta-analysis. The enrolled eight studies included five cohort studies (22)(23)(24)26,27) and three case control studies (20,21,25). The publication year ranged from 1992-2015.…”

“…P<0.05 was considered to represent statistically significant differences. A sensitivity analysis was performed by removing studies one at a time to confirm the robustness of the results (21). Publication bias was assessed by performing the Egger's test (22).…”

Impaired glucose tolerance in first-episode drug-naïve patients with schizophrenia: relationships with clinical phenotypes and cognitive deficits

“…The rapid rise of T2DM prevalence in China is largely believed to be driven by several environmental factors comprising economic development, nutrition transition and changes in lifestyles (Hu et al 2015). However, several convincing T2DM loci have been identified from large-scale genome-wide association studies and meta-analyses in the Han population (Ma et al 2015), suggesting that there may exist genetic predisposition in the Han population to develop T2DM. However, the genetic basis of T2DM and SCZ, especially the inter-relationships of their genetic loci, warrants further investigation.…”

Associations of TCF7L2 rs11196218 (A/G) and GLP-1R rs761386 (C/T) Gene Polymorphisms with Obesity in Chinese Population

“… 23 Another similar meta-analysis in the Chinese Han population did not show any association between the TCF7L2 gene rs11196218 A/G polymorphism and T2DM risk. 30 As for GLP1-R gene polymorphism, a study in the European population revealed that rs2268641 in GLP1-R was significantly associated with BMI while rs9380825 is not. 18 , 19 And there have not been studies about the GLP1-R rs761386 variant on obesity yet.…”