Association of the PSRC1 rs599839 Variant with Coronary Artery Disease in a Mexican Population

Abstract

Background and Objectives: Coronary artery disease (CAD) is a major health problem in México. The identification of modifiable risk factors and genetic biomarkers is crucial for an integrative and personalized CAD risk evaluation. In this work, we aimed to validate in a Mexican population a set of eight selected polymorphisms previously associated with CAD, myocardial infarction (MI), or dyslipidemia. Materials and Methods: A sample of 907 subjects (394 CAD cases and 513 controls) 40–80 years old was genotyped for eight loci: PSRC1 (rs599839), MRAS (rs9818870), BTN2A1 (rs6929846), MTHFD1L (rs6922269), CDKN2B (rs1333049), KIAA1462 (rs3739998), CXCL12 (rs501120), and HNF1A (rs2259816). The association between single nucleotide polymorphisms (SNPs) and CAD was evaluated by logistic regression models. Results: Multiple logistic regression analysis with adjustment by age, gender, and body mass index showed that rs599839 was significantly associated with CAD (ORADD = 0.72, p = 0.009; ORDOM = 0.66, p = 0.007). Conclusions: The PSRC1 rs599839 polymorphism shows a significant protective association with CAD in this sample of the Mexican population.

Polymorphism of rs599839 in the PSRC1 gene is associated with coronary artery disease in an Iranian population

“…The association detected in the present study was also indicated in 10 other studies, namely those by including Samani et al, 8 Samani et al, 9 Ronald et al, 10 Xu et al, 11 Zhou et al 12 Rodríguez-Arellano et al 13 Angelakopoulou et al 14 Ellis et al, 15 Lee et al, 16 and Yan et al 17 For the first time, in 2008, Huang et al 18 reported an association between the rs599839 polymorphism and low-density lipoprotein and premature CAD in 615 Chinese Han individuals. Recently, Rodríguez-Arellano et al 13 showed that rs599839 was significantly associated with CAD (additive OR, 0.72 and P value = 0.009; dominant OR, 0.66 and P value = 0.007) in a sample of 907 Mexican individuals (394 CAD cases and 513 controls). Many studies have identified an association between rs599839 (T) and higher low-density lipoprotein levels.…”

Association between Genetic Variants of CELSR2-PSRC1-SORT1 and Cardiovascular Diseases: A Systematic Review and Meta-Analysis

“…Previous studies have explored the relationship between the rs599839 polymorphism and coronary artery disease [ 15 , 28 ]. Although we found a strong risk association, Rodríguez-Arellano ME, 2020, reported a protective association with CAD in the Mexican population [ 16 ]. These contradictory results could be due to variables that affect the genotype–phenotype association, such as age, ancestry, gene–environment interactions, sex, and sample size.…”

“…Some of these SORT1 -associated functions lead to an increased risk of cardiovascular diseases. However, the results regarding these three genes and their participation in CVDs are so far contradictory and not well understood [ 8 , 15 , 16 ]. Likewise, previously reported associations show the possible role of these genetic variants.…”

SORT1 rs599839 Polimorfizminin Lipit Profillerine Olan Etkisi: Tek Şehir Deneyimi

“…Çalışma gruplarına ait demografik verilerHintliler32 , Japonlar33 , Çinliler34 , Pakistanlılar35 ve Meksikalılarda36 yapılan çalışma verileri ile uyumluluk göstermektedir. LDL-K seviyelerinde gözlemlediğimiz bu düşüşün minör G allel varlığında daha önce yapılmış çalışma verileriyle uyumlu olan artan SORT1 ekspresyonunun LDL'nin hücre içi alımında yarattığı artış nedeniyle olduğunu düşünüyoruz28 .…”