Association of the mutagenicity of airborne particles with the direct emission from combustion processes investigated in Osaka, Japan

Kameda, Takayuki; Sanukida, Satoshi; Inazu, Koji; Hisamatsu, Yoshiharu; Maeda, Yasuhiro; Takenaka, Norimichi; Bandow, Hiroshi

doi:10.1016/j.atmosenv.2004.07.032

Cited by 10 publications

(5 citation statements)

References 22 publications

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“…[6][7][8] Several authors investigated the concentrations of mutagenic compounds and mutagenic activities of PM fractionated according to size: the conclusion is that mutagenic compounds, such as polycyclic aromatic hydrocarbons (PAHs) and nitrated polycyclic aromatic hydrocarbons (nitro-PAHs), are mainly present in the fine particle fraction, [9][10][11][12] and most of the mutagenic activity is observed in fine particle fraction. 10,[13][14][15] However, very little information is available about the mutagenic activity of ultrafine particles and their contribution to the total mutagenic activity.…”

Section: Introductionmentioning

confidence: 99%

Mutagenic Activity of Atmospheric Ultrafine Particles at a Roadside Site and a Suburban Site

Kawanaka

Matsumoto²,

Wang³

et al. 2006

JOURNAL OF HEALTH SCIENCE

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Section: Introductionmentioning

confidence: 99%

Mutagenic Activity of Atmospheric Ultrafine Particles at a Roadside Site and a Suburban Site

Kawanaka

Matsumoto²,

Wang³

et al. 2006

JOURNAL OF HEALTH SCIENCE

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“…Τα στελέχη του μικροοργανισμού Salmonella typhimurium που χρησιμοποιούνται είναι τα TA98 (Cerna et al, 1999(Cerna et al, , 2000Binkova et al, 2003;Brits et al, 2004;Cassoni et al, 2004;Du Four et al, 2004;Erdinger et al, 2004;Pastorkova et al, 2004;Gilli et al, 2007;Kawanaka et al, 2006Kawanaka et al, , 2008, TA100 (Cerna et al, 1999(Cerna et al, , 2000Binkova et al, 2003;Du Four et al, 2004;Erdinger et al, 2004), YG1041 (Pastorkova et al, 2004), YG1024 (Kameda et al, 2004b;Kawanaka et al, 2008), ενώ χρησιμοποιείται ηπατικός μεταβολίτης (S9) για την ενεργοποίηση της ικανότητας μεταλλαξιγένεσης των οργανικών ενώσεων που περιέχονται στα σωματίδια.…”

Section: δοκιμές μεταλλαξιγόνου δραστικότητας-Ames Testunclassified

“…Η χρήση των ειδικών στελεχών YG, που είναι ευαίσθητα σε ορισμένες κατηγορίες ενώσεων, όπως οι νιτροενώσεις, ενδεχομένως να οδηγήσουν στην παρερμηνεία των αποτελεσμάτων, εάν δεν χρησιμοποιούνται ταυτόχρονα και άλλα στελέχη (Claxton and Woodall, 2007). Ειδικότερα, τα YG1024 είναι περισσότερο ευαίσθητα στελέχη από τα TA98, χρησιμοποιούνται για την ανίχνευση των μεταλλάξεων από νιτροαρένια (Kameda et al, 2004b), και τα YG1041 είναι περισσότερο ευαίσθητα στις μεταλλάξεις που προκαλούνται από τους νιτρο-πολυλυκυκλικούς αρωματικούς υδρογονάνθρακες (NPAHs). Επομένως, η αποκλειστική εφαρμογή τους σημαίνει ότι η μεταλλαξιγόνος δραστικότητα αποδίδεται μόνο στις συγκεκριμένες νιτροαρωματικές ενώσεις, οπότε δε λαμβάνονται υπόψη άλλες κατηγορίες, όπως οι πολυλυκυκλικοί αρωματικοί υδρογονάνθρακες (PAHs).…”

Section: δοκιμές μεταλλαξιγόνου δραστικότητας-Ames Testunclassified

“…Παρόμοιες τιμές αναφέρονται και από άλλους ερευνητές για περιοχές με μεγάλη κίνηση οχημάτων (380 pg m -3 , Cecinato et al, 1999;221 pg m -3 , Dimashki et al, 2000;191 pg m -3 , Hien et al, 2007b). Οι Kameda et al, (2004b), απέδωσαν τις υψηλότερες συγκεντρώσεις του 2-NFl σε περιοχή αστικού υποβάθρου (8,20 pmol m -3 ) σε σύγκριση με τις αντίστοιχες αστικής περιοχής πυκνής κυκλοφορίας οχημάτων…”

Section: περιεκτικότητα των σωματιδιακών κλασμάτων σε Pahsunclassified

“…Οι τιμές της μεταλλαξιγόνου δραστικότητας των αιωρούμενων σωματιδίων που προσδιορίστηκαν στην παρούσα εργασία, βρίσκονται μέσα στο εύρος τιμών που δίνονται στη βιβλιογραφία για αστικές περιοχές (40 αποικίες/m 3 με το στέλεχος ΤΑ98 στα σωματίδια PM 10 , Du Four et al, 2004; 78 και 177 αποικίες/m 3 με τα στελέχη ΤΑ98 και TA100 στα σωματίδια PM 2,5 , Gilli et al, 2007). Υψηλότερος αριθμός αποικιών/m 3 στα ολικά αιωρούμενα σωματίδια, παρατηρήθηκε τις πρωινές (51,5 έως 54,4 αποικίες/m 3 ) σε σύγκριση με τις απογευματινές ώρες (16,1 έως 49,9 αποικίες/m 3 ) όπως αναμενόταν, εξαιτίας των εκπομπών από την κυκλοφορία των οχημάτων (Kameda et al, 2004b).…”

Section: Mεταλλαξιγόνος δραστικότηταunclassified

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Μελέτη Της Κατανομής Και Της Βιοδραστικότητας Σωματιδιακών Οργανικών Ρύπων Στην Ατμόσφαιρα Αστικών Περιοχών

Chrysikou¹,

Χρυσικού²

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The aim of this research was (1) to investigate the distribution of organic compounds associated with size segregated atmospheric aerosols, (2) to determine the redox activity and the mutagenicity of size-fractionated particulate matter (PM) and (3) to assess the role of organic species in generating these biological activities. More precisely, the concentrations of 18 PAHs, 2 NPAHs, 19 OCPs, 6 PCBs, 10 AHs and 2 isoprenoids compounds were determined in different size fractions. Seasonal variations of concentration levels, particle size distribution were also examined, so as to estimate their ambient environmental sources and to provide helpful information about the environmental levels of these harmful substances. Furthermore, the biological effects of size-separated PM were determined by measuring the mutagenicity using S.Typhimurium strains TA98 and TA100, with and without metabolic activation and the redox activity. Data form the biological tests were correlated with chemical data in order to elucidate the mutagenicity and the redox activity of size fractions as a result of the presence of the targeted compounds or not. Sample acquisition was carried out at an urban site of Thessaloniki, adjacent to a busy street, during winter (11-27 December 2007) and summer (3-27 June 2008). Particles were separated into five fractions (4 stages and a back up filter) resulting in size ranges of >7,5, 7,5-3,0, 3,0-1,5, 1,5-0,95, <0,95 μm. During the analytical procedure, organic extracts were fractionated using glass column chromatography and all 4 fractions eluted were divided into two parts for chemical analysis and biological assays. The main conclusions of this research could be summarised to the following: • Concentrations of PM and organic compounds The total PM calculated from all impactor stages were 127 μg m-3 in summer and 272 μg m-3 in winter, respectively. The concentration of PM was found to be highest at particle diameters <0,95 μm in both sampling campaigns. Significant seasonal variations were observed in particle size fractions 0,95-1,5 μm, 1,5-3,0 μm with the highest concentrations during the cold period. Total n-alkanes (sum of all size fractions), ΣΝΑ were 59,4 ng m-3 in summer and 123 ng m-3 in winter, respectively. The concentrations of ΣΝΑ and of several AHs in various size fractions were significantly higher in winter, reflecting inputs from central heating. ΣOCPs mean concentrations (sum of all size fractions) were 101 pg m-3 in summer and 217 pg m-3 in winter, respectively. ΣPCBs mean concentrations varied from 12 pg m-3 in the cold period to 93 pg m-3 in the warm period. The highest concentrations of these species were found on particles <0,95 μm in both sampling campaigns. Elevated levels of several of these compounds during summer are attributed to an increasing input of secondary sources e.g volatilization from environmental compartments. Total PAH concentrations (sum of all size fractions) ΣPAH, ranged from 8,54 ng m-3 in summer to 24,6 ng m-3 in winter, respectively. Seasonal variations were important for ΣPAH (particles <0,95 μm, 0,95-1,5 μm, TSP) and for several PAHs in the various size ranges with the highest concentrations found in winter period. Even though, the concentrations of ΣPAH in particles >7,5 μm were significantly higher in summer period.

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Heterogeneous reactivity of pyrene and 1-nitropyrene with NO2: Kinetics, product yields and mechanism

Miet

Ménach

Flaud

et al. 2009

Atmospheric Environment

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Association of the mutagenicity of airborne particles with the direct emission from combustion processes investigated in Osaka, Japan

Cited by 10 publications

References 22 publications

Mutagenic Activity of Atmospheric Ultrafine Particles at a Roadside Site and a Suburban Site

Mutagenic Activity of Atmospheric Ultrafine Particles at a Roadside Site and a Suburban Site

Μελέτη Της Κατανομής Και Της Βιοδραστικότητας Σωματιδιακών Οργανικών Ρύπων Στην Ατμόσφαιρα Αστικών Περιοχών

Heterogeneous reactivity of pyrene and 1-nitropyrene with NO2: Kinetics, product yields and mechanism

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