Association of the microsatellite (GT)<sub>n</sub> repeat polymorphisms of the HO-1 gene promoter and corresponding serum levels with the risk of laryngeal squamous cell carcinoma

Tang, Di; Tang, Weijing; Shi, Xiaoling; Zhou, Hong; Lu, Liming; Tao, Lei

doi:10.3109/00016489.2016.1157265

Cited by 9 publications

(13 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, the long (GT)n repeats in HMOX1 gene promoter was reported to correlate with a higher risk of breast cancer [ 54 ], esophageal squamous cell carcinoma [ 55 ] and laryngeal squamous cell carcinoma [ 56 ]. More complicated, other studies showed no correlation between HMOX1 polymorphism and the risk of lung squamous cell carcinoma [ 57 ] and sporadic colorectal cancer [ 58 ], indicating that the final outcome may depend on several factors including the type of the tumor, subject ethnicity, and many others.…”

Section: Association Between Ho-1 Gene Polymorphism and Cancermentioning

confidence: 99%

Heme oxygenase inhibition in cancers: possible tools and targets

Podkalicka¹,

Mucha²,

Józkowicz³

et al. 2018

View full text Add to dashboard Cite

Heme oxygenase-1 (HO-1, encoded by HMOX1) through degradation of pro-oxidant heme into carbon monoxide (CO), ferrous ions (Fe2+) and biliverdin, exhibits cytoprotective, anti-apoptotic and anti-inflammatory properties. All of these potentially beneficial functions of HO-1 may play an important role in tumors’ development and progression. Moreover, HO-1 is very often upregulated in tumors in comparison to healthy tissues, and its expression is further induced upon chemo-, radio- and photodynamic therapy, what results in decreased effectiveness of the treatment. Consequently, HO-1 can be proposed as a therapeutic target for anticancer treatment in many types of tumors. Nonetheless, possibilities of specific inhibition of HO-1 are strongly limited. Metalloporphyrins are widely used in in vitro studies, however, they are unselective and may exert serious side effects including an increase in HMOX1 mRNA level. On the other hand, detailed information about pharmacokinetics and biodistribution of imidazole-dioxolane derivatives, other potential inhibitors, is lacking. The genetic inhibition of HO-1 by RNA interference (RNAi) or CRISPR/Cas9 approaches provides the possibility to specifically target HO-1; however, the potential therapeutic application of those methods are distant at best. In summary, HO-1 inhibition might be the valuable anticancer approach, however, the ideal strategy for HO-1 targeting requires further studies.

show abstract

Section: Association Between Ho-1 Gene Polymorphism and Cancermentioning

confidence: 99%

Heme oxygenase inhibition in cancers: possible tools and targets

Podkalicka¹,

Mucha²,

Józkowicz³

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The titles and abstracts were reviewed considering the inclusion and exclusion criteria. Finally, 5 articles were considered eligible for this systematic review: Zhou et al ( 23 ), Zhou et al ( 17 ), Tang et al ( 16 ), Zhou et al ( 6 ), and Yang et al ( 5 ).…”

Section: Resultsmentioning

confidence: 99%

“…Studies have found a significant positive association between molecular markers and VFL ( 6 , 16 ), but some researchers did not find a genetic association ( 5 , 17 ). Besides, the lack of review studies on this topic emphasizes the need for evidence synthesis to better understand the genetics in VFL etiology.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms and protein levels in vocal fold leukoplakia: a systematic review

Campello

Lima-Silva

Lima

et al. 2022

Braz J Med Biol Res

View full text Add to dashboard Cite

Vocal fold leukoplakia (VFL) has a risk of malignant transformation. Therefore, patients can have symptoms such as dysphonia, vocal strain, difficulty breathing, and dysphagia. Additionally, there is a genetic predisposition that can be associated with genetic polymorphisms. We aimed to evaluate the influence of genetic polymorphisms and protein levels in the etiology of VFL. Our study followed the PRISMA checklist and was registered on PROSPERO database. The questions were: “Are genetic polymorphisms involved in the etiology of VFL? Are protein levels altered in patients with VFL?”. Eligibility criteria were case control studies that compared the presence of polymorphisms or/and protein levels of subjects diagnosed with VFL and healthy controls. Of the 905 articles retrieved, five articles with a total of 1038 participants were included in this study. The C allele of the single nucleotide polymorphisms (SNP)-819 T/C IL-10 , A allele of the SNP -592 A/C IL-10 , CT genotype of the SNP rs11886868 C/T BCL11A , GG genotype of the SNP rs4671393 A/G BCL11A , LL genotype, and L allele of (GT)n repeat polymorphisms of the HO-1 were risk factors for VFL development. Nevertheless, there was a lack of association between VFL and the -1082 A/G IL-10 , rs14024 CK-1 , and -309 T/G Mdm2 SNPs. The concentrations of the MDM2, BCL11A, and HO-1 proteins were modified, while IL-10 levels were normally expressed in these subjects. In conclusion, most markers evaluated in this review could be potential indicators to develop effective therapies, avoiding a malignant transformation of the lesion.

show abstract

“…in pediatric patients with acute lymphoblastic leukemia, patients with Ho-1 S (GT) n repeats were associated with chemotherapy resistance and chemo-induced neutropenia (92). in other studies, l (GT)n repeats in the promoter of the Ho-1 gene have been reported to be associated with a higher risk of breast cancer, esophageal squamous cell carcinoma and laryngeal squamous cell carcinoma (67,(93)(94)(95).…”

Section: Association Between Ho-1 Gene Polymorphism and Clinical Diseasesmentioning

confidence: 92%

Association between HO‑1 gene promoter polymorphisms and diseases (Review)

Sun

Wang

et al. 2021

Mol Med Rep

View full text Add to dashboard Cite

Heme oxygenase-1 (Ho-1) is an inducible cytoprotective enzyme that degrades heme into free iron, carbon monoxide and biliverdin, which is then rapidly converted into bilirubin. These degradation products serve an important role in the regulation of inflammation, oxidative stress and apoptosis. While the expression level of Ho-1 is typically low in most cells, it may be highly expressed when induced by a variety of stimulating factors, a process that contributes to the regulation of cell homeostasis. in the 5'-non-coding region of the Ho-1 gene, there are two polymorphic sites, namely the (GT)n dinucleotide and T(-413)a single nucleotide polymorphism sites, which regulate the transcriptional activity of Ho-1. These polymorphisms have been shown to be closely associated with the occurrence and progression of numerous diseases, including cardiovascular, pulmonary, liver and kidney, various types of cancer and viral diseases. The present article reviews the progress that has been made in research on the association between the two types of polymorphisms and these diseases, which is expected to provide novel strategies for the diagnosis, treatment and prognosis of various diseases. Contents1. introduction 2. regulation of Ho-1 expression 3. Ho-1 promoter polymorphism 4. association between Ho-1 gene polymorphism and clinical diseases 5. conclusions and prospects

show abstract

Association of the microsatellite (GT)_n repeat polymorphisms of the HO-1 gene promoter and corresponding serum levels with the risk of laryngeal squamous cell carcinoma

Cited by 9 publications

References 19 publications

Heme oxygenase inhibition in cancers: possible tools and targets

Heme oxygenase inhibition in cancers: possible tools and targets

Genetic polymorphisms and protein levels in vocal fold leukoplakia: a systematic review

Association between HO‑1 gene promoter polymorphisms and diseases (Review)

Contact Info

Product

Resources

About

Association of the microsatellite (GT)n repeat polymorphisms of the HO-1 gene promoter and corresponding serum levels with the risk of laryngeal squamous cell carcinoma

Cited by 9 publications

References 19 publications

Heme oxygenase inhibition in cancers: possible tools and targets

Heme oxygenase inhibition in cancers: possible tools and targets

Genetic polymorphisms and protein levels in vocal fold leukoplakia: a systematic review

Association between HO‑1 gene promoter polymorphisms and diseases (Review)

Contact Info

Product

Resources

About

Association of the microsatellite (GT)_n repeat polymorphisms of the HO-1 gene promoter and corresponding serum levels with the risk of laryngeal squamous cell carcinoma