Association of the Metabolic Syndrome with Severe Periodontitis in a Large U.S. Population-Based Survey

Abstract

Severe periodontitis is associated with metabolic syndrome in middle-aged individuals. Further studies are required to test whether improvements in oral health lead to reductions in cardiometabolic traits and the risk of metabolic syndrome or vice versa.

Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept

“…We [4,17,18] and others [3] have demonstrated the influence of gut microbiota on metabolic disease in animal models. Consistently, in humans, periodontitis, a chronic gram-negative infectious disease of the oral cavity, has been associated with the metabolic syndrome [19][20][21][22][23]. In line with these data, the longitudinal study reported here provides for the first time evidence of the involvement of tissue microbiota in the development of diabetes in humans.…”

The Association between the Condition of Dentition and Myocardial Infarction Risk

“…The positive correlation between Acute Coronary Syndrome and inflammatory markers such as CRP, IL-1, IL-6, TNF-α was observed [10,11]. In blood plasma or serum it is possible to assess the concentration of inflammatory markers, such as Interleukin 6 (IL-6) and C-reactive protein (hs-CRP, highsensitivity C-reactive protein).…”

“…In blood plasma or serum it is possible to assess the concentration of inflammatory markers, such as Interleukin 6 (IL-6) and C-reactive protein (hs-CRP, highsensitivity C-reactive protein). These markers are useful to identify people with high risk of Incident Cardiovascular Events [10][11][12][13][14]. Cytokines are the mediators of inflammatory process and immune response in human body.…”

Involvement of psychosocial factors in the association of obesity with periodontitis

“…Various cross-sectional and case-control studies have found a strong association between obesity and periodontal disease (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). It has also been revealed that metabolic syndrome increases the risk of periodontitis, suggesting that people exhibiting several components of metabolic syndrome should be encouraged to undergo regular periodontal examination (7,13,14,(17)(18)(19).…”

“…It has also been revealed that metabolic syndrome increases the risk of periodontitis, suggesting that people exhibiting several components of metabolic syndrome should be encouraged to undergo regular periodontal examination (7,13,14,(17)(18)(19).…”