Association of the miR‐146aC&gt;G, 149C&gt;T, 196a2C&gt;T, and 499A&gt;G polymorphisms with colorectal cancer in the Korean population

Min, Kyungha; Kim, Jong Woo; Jeon, Young Joo; Jang, Moon Ju; Chong, So Young; Oh, Doyeun; Kim, Nam Keun

doi:10.1002/mc.21849

Cited by 88 publications

(85 citation statements)

References 47 publications

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“…One study was excluded as it was not associated with hsa-mir-499 rs3746444 A>G (Kupcinskas et al, 2012). After further excluding two abstracts (Hu et al, 2009;Hwang et al, 2010), thirty-nine case-control studies involving 14,136 cases and 16,937 controls were selected for meta-analysis (Hu et al, 2009;Tian et al, 2009;Catucci et al, 2010;Liu et al, 2010;Okubo et al, 2010;Srivastava et al, 2010;Akkiz et al, 2011;George et al, 2011;Ling et al, 2011;Mittal et al, 2011;Vinci et al, 2011;Zhou et al, 2011;Alshatwi et al, 2012;Chu et al, 2012;Kim et al, 2012;Min et al, 2012;Xiang et al, 2012;Zhou et al, 2012;Ahn et al, 2013;Lv et al, 2013;Shan et al, 2013;Song et al, 2013;Umar et al, 2013;Vinci et al, 2013;Wei et al, 2013;Wu et al, 2013;Zou and Zhao, 2013;Bansal et al, 2014;Chu et al, 2014;Du et al, 2014;Gutierrez-Camino et al, 2014;Hasani et al, 2014;Hou et al, 2014;Hu et al, 2014;Ma et al, 2014;Omrani et al, 2014;Pu et ...…”

Section: Methodsmentioning

confidence: 99%

Lack of Association between Hsa-Mir-499 rs3746444 Polymorphism and Cancer Risk: Meta-analysis Findings

Jiang

Chen²,

Tang³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Epidemiologic findings concerning the association between the hsa-mir-499 rs3746444 A>G polymorphism and cancer risk have yielded mixed results. We aimed to investigate the association by performing a meta-analysis of all available studies. We searched PubMed and EMBASE for studies published up to November 2014, using odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of any association. The BenjaminiHochberg (BH) method was used to correct the p values for multiple comparisons. We included 39 studies, including 14,136 cases and 16,937 controls. The results of overall meta-analysis suggested a borderline association between hsa-mir-499 rs3746444 polymorphism and cancer susceptibility (AG+GG vs. AA: OR=1.15, 95% CI= 1.04-1.26, corrected p value=0.04). After removing studies not conforming to Hardy-Weinberg equilibrium (HWE), however, this association disappeared (AG+GG vs AA: OR=1.18, 95% CI=1.03-1.34, corrected p value=0.21). When stratified analysis by ethnicity, cancer type or HWE in controls, although some associations between hsa-mir-499 rs3746444 polymorphism and cancer susceptibility were detected, these associations no longer existed after adjustment using BH method. In conclusion, our meta-analysis suggests that hsa-mir-499 rs3746444 A>G polymorphism is not associated with risk of cancer based on current evidence. conclusive. Many meta-analyses have examined the association of the polymorphism with cancer risk and the lasted one suggested that hsa-mir-499 rs3746444 polymorphism was a risk factor for cancer development. Since the latest meta-analysis had been performed, nineteen case-control studies (Ling

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Section: Methodsmentioning

confidence: 99%

Lack of Association between Hsa-Mir-499 rs3746444 Polymorphism and Cancer Risk: Meta-analysis Findings

Jiang

Chen²,

Tang³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Some researchers have examined the association of miR-146a rs2910164 G > C polymorphism with several cancers risks, and a significant relationship was observed in several but not all studies (Xu et al, 2008;Guo et al, 2010;Okubo et al, 2010;Srivastava et al, 2010;Zeng et al, 2010;Akkız et al, 2011;Hishida et al, 2011;Min et al, 2011;Zhang et al, 2011;Zhou et al, 2011). Such as, some studies have divided cases and controls into HBV infection according to HBV DNA amount, and some researchers have taken into account age and other factors, so each obtained the different results.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, single nucleotide polymorphism (SNP, rs2910164) has been identified in the miR-146a gene. More recently, Several studies have assessed the relationship between the polymorphism of miR-146a G > C and the risks to digestive cancers, however, the results have been controversial (Xu et al, 2008;Guo et al, 2010;Okubo et al, 2010;Srivastava et al, 2010;Zeng et al, 2010;Akkız et al, 2011;Hishida et al, 2011;Min et al, 2011;Zhang et al, 2011;Zhou et al, 2011). To derive a more precise effect on the association between miR-146a polymorphism and digestive cancers risks.…”

Section: Research Articlementioning

confidence: 99%

“…Following the above inclusion and exclusion criteria, 9 publications were included in the final meta-analysis (Xu et al, 2008;Guo et al, 2010;Okubo et al, 2010;Srivastava et al, 2010;Zeng et al, 2010;Akkız et al, 2011;Hishida et al, 2011;Min et al, 2011;Zhang et al, 2011;Zhou et al, 2011). Characteristics of studies focusing on miR146a rs2910164 G > C are summarized in Table 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

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The miR-146a rs2910164 G > C Polymorphism and Susceptibility to Digestive Cancer in Chinese

Wang²,

Dai³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Previous studies demonstrated that high expression levels of miR-196a2 may promote the migration and invasion of CRC cells and the C allele of rs11614913 polymorphism may affect miR-196a2 expression levels in cancer (13)(14)(15)(16). Several previous studies reported the association between rs11614913 polymorphisms and the susceptibility to CRC (15,(17)(18)(19)(20)(21). However, those studies produced controversial and inconclusive results.…”

Section: Introductionmentioning

confidence: 99%

A functional polymorphism rs11614913 in microRNA-196a2 is associated with an increased risk of colorectal cancer although not with tumor stage and grade

Wang

Zhu

et al. 2013

Biomedical Reports

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Abstract. A C/T polymorphism (rs11614913) was identified in the microRNA (miRNA) 196a2 (miR-196a2) gene and was implicated in the susceptibility to cancer. Numerous studies have investigated its association with the risk of colorectal cancer (CRC). However, the results were inconsistent and inconclusive. The present meta-analysis was conducted based on the results of six published case-control studies comprising 1,754 cases and 2,430 controls (up to November, 2012). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for the allelic and genotypic comparisons following the co-dominant, dominant and recessive genetic models. The Chi-square-based Q-test was used to assess heterogeneity. Egger's test and inverted funnel plots were used to investigate publication bias. Subgroup analysis was also performed. The results demonstrated that almost all the genetic models (except the model of CT vs. TT) indicated a significant association between rs11614913 polymorphism and CRC risk. The subgroup analysis in an Asian population also demonstrated similar results. However, there was no significant association of miR-196a2 rs11614913 polymorphism with the clinical characteristics of CRC patients. Our results confirmed the association of the polymorphism rs11614913 with the risk of CRC, but not with tumor stage and grade.

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Association of the miR‐146aC>G, 149C>T, 196a2C>T, and 499A>G polymorphisms with colorectal cancer in the Korean population

Cited by 88 publications

References 47 publications

Lack of Association between Hsa-Mir-499 rs3746444 Polymorphism and Cancer Risk: Meta-analysis Findings

Lack of Association between Hsa-Mir-499 rs3746444 Polymorphism and Cancer Risk: Meta-analysis Findings

The miR-146a rs2910164 G > C Polymorphism and Susceptibility to Digestive Cancer in Chinese

A functional polymorphism rs11614913 in microRNA-196a2 is associated with an increased risk of colorectal cancer although not with tumor stage and grade

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