The miR-146a rs2910164 G &gt; C Polymorphism and Susceptibility to Digestive Cancer in Chinese

ABSTRACT. The associations between two common polymorphisms in microRNA genes (miR-146a, dbSNP: rs2910164; miR-196a-2, dbSNP: rs11614913) and gastric cancer risk have frequently been examined; however, the results have often been controversial. This meta-analysis was performed to clarify the association between the two polymorphisms and gastric cancer risk. The literature search primarily utilized PubMed, Embase, SinoMed, and Wanfang databases to identify eligible studies. Odds ratios (ORs) with their 95% confidence intervals (CIs) were analyzed to investigate possible correlations. Subgroup analyses of ethnicity as well as source of controls were also performed. The correlation analysis was based on 11 studies, containing 4690 patients and 6066 controls for miR-146a (C>G) together with 1911 patients and 2484 controls for miR-196a-2 (T>C). For the miR-146a polymorphism, the values of the ORs and 95%CIs were >1, suggesting (2015) that a correlation exists. In subgroup analysis of source of controls, a correlation was also identified in the Asian subgroup. However, in Caucasians the ORs and 95%CIs were not distributed on the same side of the critical value 1, contra-indicative of a correlation in this group. For the miR-196a-2 polymorphism, the ORs with 95%CIs of both overall and subgroup analyses were also not restricted to >1 or ˂1. In summary, the results suggested that the miR-146a rs2910164 polymorphism was related to gastric cancer risk in Asians but not in Caucasians, and no distinct correlation seemed to exist between the miR-196a-2 rs11614913 polymorphism and the risk of gastric cancer.

Section: Introductionmentioning

confidence: 99%

Common polymorphisms of the microRNA genes (miR-146a and miR-196a-2) and gastric cancer risk: an updated meta-analysis

Chen

Xue

2015

“…Regarding the first report of the polymorphism in gastric cancer, Zeng et al (2010) found that subjects with pre-miR-146a rs2910164 GC/GG genotypes had a 1.58-fold elevated risk of gastric cancer compared to carriers of the CC genotype [95% confidence interval (CI) = 1.11-2.20; P = 0.009]. For SNPs in pri-miRNA, Xu et al (2014b) reported an rs629367 polymorphism located in pri-let-7a-2 and the CC genotype was associated with an increased risk (Xu et al, 2014a,c) let-7a-2 rs629367, rs1143770 (Xu et al, 2014a) let-7f-2 rs17276588 miR-124 rs531564 (Zhou et al, 2012b;Xu et al, 2015) miR-26a-1 rs7372209 (Zhou et al, 2012b;Stenholm et al, 2013;Xu et al, 2015) miR-938 rs2505901 (Arisawa et al, 2012) pre-miRNA miR-146a rs2910164 (Okubo et al, 2010;Zeng et al, 2010;Hishida et al, 2011;Wang et al, 2012;Zhou et al, 2012a,b;Ahn et al, 2013;Ma et al, 2013;Stenholm et al, 2013;Wu et al, 2013a;Dikeakos et al, 2014;Kupcinskas et al, 2014;Li et al, 2014b;Parlayan et al, 2014;Pu et al, 2014;Tahara et al, 2014;Xu et al, 2014dXu et al, , 2015 rs11614913 (Okubo et al, 2010;Peng et al, 2010;Ahn et al, 2013;Ma et al, 2013;Stenholm et al, 2013;Wang et al, 2013a;Dikeakos et al, 2014;Kupcinskas et al, 2014;Parlayan et al, 2014;Pu et al, 2014;Tahara et al, 2014;Xu et al, 2015) miR-149 rs2292832 …”

Section: Resultsmentioning

confidence: 99%

“…In case-control studies, some authors reported a positive result (Okubo et al, 2010;Zeng et al, 2010;Zhou et al, 2012a;Kupcinskas et al, 2014) and others reported a negative result (Hishida et al, 2011;Ahn et al, 2013;Dikeakos et al, 2014;Parlayan et al, 2014). To make the results more precise, some authors performed meta-analyses by combining all the data together (Ma et al, 2013;Wu et al, 2013a;Li et al, 2014b;Xu et al, 2014dXu et al, , 2015, which improved the statistical power. However, conflicting results were still present.…”

Section: Association Of the Pre-mir-146a Rs2910164 Polymorphism With mentioning

confidence: 99%

“…Over the past several years, the association of the pre-miR-146a rs2910164 polymorphism with risk of gastric cancer has been extensively investigated (Okubo et al, 2010;Zeng et al, 2010;Hishida et al, 2011;Wang et al, 2012;Zhou et al, 2012a,b;Ahn et al, 2013;Ma et al, 2013;Stenholm et al, 2013;Wu et al, 2013a;Dikeakos et al, 2014;Kupcinskas et al, 2014;Li et al, 2014b;Parlayan et al, 2014;Pu et al, 2014;Tahara et al, 2014;Xu et al, 2014dXu et al, , 2015. In total, 18 studies were involved, including 10 case-control studies, 6 meta-analyses, and 2 case-only studies.…”

Section: Association Of the Pre-mir-146a Rs2910164 Polymorphism With mentioning

confidence: 99%

See 1 more Smart Citation

A comprehensive review of microRNA-related polymorphisms in gastric cancer

Han¹,

Li²,

Liu³

et al. 2016

ABSTRACT. MicroRNAs (miRNAs) are a class of small non-coding RNA molecules of about 22 nucleotides in length. miRNAs are highly conserved in both plants and animals, and function as gene regulators by binding to the 3'-untranslated region of target mRNAs for cleavage and/ or translational repression. miRNA biogenesis, stability, and regulation of expression are strongly sequence dependent. Sequence variants, such as single nucleotide polymorphisms (SNPs) in pri-miRNA, pre-miRNA, promoter regions, or miRNA-target sites, can influence miRNA function, thereby contributing to the pathological features of human disease. In this review, we focus on miRNA-related SNPs in gastric cancer and comprehensively analyze some commonly studied SNPs.

“…In addition, whereas several previous meta-analyses regarding associations between the five common SNPs in miRNA genes and GC have been published, these meta-analyses did not include many eligible studies (Chu et al, 2011;Qiu et al, 2011a,b;Xu et al, 2011;Guo et al, 2012;Zhang et al, 2012a;Wang et al, 2012aWang et al, ,b,c,d,e, 2013aWu et al, 2013a). Therefore, we performed an updated and comprehensive meta-analysis on published studies to investigate the correlation between the five common SNPs in miRNA genes and GC susceptibility; and, ideally, to provide evidence useful for the early diagnosis of GC.…”

Section: Introductionmentioning

confidence: 99%

Association between five common polymorphisms in microRNA genes and the risk of gastric cancer: a meta-analysis

Zhang

et al. 2015

ABSTRACT. Gastric cancer (GC) is a prevalent disease with a high mortality rate, especially in developing countries. Accumulating evidence suggests that single nucleotide polymorphisms in microRNA (miRNA) genes might influence the susceptibility to GC; such sequence variation might contribute to the development of disease by altering crucial cellular pathways. In this study, we assessed the correlation between the miR-146a G>C, miR-196a-2 C>T, miR-499 T>C, miRNA27a A>G, and miRNA-149 T>C polymorphisms and the susceptibility to GC. A comprehensive literature search for relevant studies published prior to August 2014 was conducted using PubMed/Medline, Embase, Web of Science, the Cochrane Library, and CNKI databases along with Google Scholar. Meta-analysis was performed using odds ratios (ORs) and 95% confidence intervals (CIs) as effect measures, incorporating 19 studies encompassing 8285 patients and 10,716 controls. Allelic, dominant, recessive, homozygous, and heterozygous genetic models were examined. Pooled results showed that none of the five polymorphisms studied were statistically related to GC. Stratified analyses by ethnicity and source of controls were conducted for miR146a G>C and miR-196a-2 C>T. Subgroup analysis suggested that the miR-146a G allele might increase the risk of GC in hospital-based case-control (HCC) but not in population-based case-control studies (HCC: recessive model: OR = 1.23, 95%CI = 1.10-1.37, P < 0.001; heterozygous model: OR = 1.19, 95%CI = 1.06-1.34, P = 0.004). Overall, this meta-analysis failed to detect an association between five common miR-146a gene polymorphisms and GC susceptibility. However, this does not necessarily completely rule out a correlation between miRNA polymorphisms and GC susceptibility.