Association of the5-HTTLPRgenotype and unipolar depression: a meta-analysis

Abstract

Our results support the presence of a small effect of a polymorphism in the serotonin transporter promoter on susceptibility to depression. However, we caution that it is possible that the effect has an artifactual basis, rather than a biological origin.

SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

“…Furthermore, two single-nucleotide polymorphisms (SNPs) within 5-HTTLPR, rs25531 and rs25532, have been found to affect transcriptional activity (Murphy and Lesch, 2008). In accordance with findings in the SERT-KO mice, the low-expressing s allele of the 5-HTTLPR has been associated with anxiety-related personality traits Holmes et al, 2003b) and neuropsychiatric conditions such as bipolar disorder (Cho et al, 2005;Lasky-Su et al, 2005), autism (Huang and Santangelo, 2008), obsessive-compulsive disorder (OCD) (Lin, 2007), 610 KRISTENSEN ET AL. eating disorders (Calati et al, 2011), major depressive disorder (Clarke et al, 2010;Kiyohara and Yoshimasu, 2010), and predisposition to develop depression in response to stressful life events (Caspi et al, 2003). However, two recent meta-analyses have failed to support a correlation among 5-HTTLPR, stress, and depression (Munafò et al, 2009;Risch et al, 2009), and this geneby-environment interaction is still the subject of debate (Risch et al, 2009;Wankerl et al, 2010).…”

The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders

“…Meta-analyses of biological candidate gene studies have provided some support for association between MDD and specific variants (Gatt et al, 2015). In particular, nominal associations have been reported in meta-analyses for variants in several serotonergic genes (HTR2A, SLC6A4 HTR1A, TPH2) (Gao et al, 2012;Kishi et al, 2013;Lopez-Leon et al, 2007;Zhao et al, 2014), as well as APOE, DRD4, GNB3, SLC6A3, and MTHFR (Clarke et al, 2010;Lopez-Leon et al, 2007;Wu et al, 2013). Of note, however, none of these genes has been implicated in large GWAS (Wray et al, 2012).…”

The DSM5/RDoC debate on the future of mental health research: implication for studies on human stress and presentation of the signature bank

“…depressive symptoms) using various units of analysis (e.g. stress hormone levels (Claes, 2009;Munafo et al, 2009), genes (Clarke et al, 2010;Hudziak et al, 2000;Rende et al, 1999) and brain imaging (Krishnan et al, 1991;Sheline et al, 1996;Vythilingam et al, 2004)). Second, developmental aspects are represented as changes to the domains of functioning over time.…”