Association of the Human Y Chromosome with Cholesterol Levels in the General Population

Charchar, Fadi J.; Tomaszewski, Maciej; Łacka, B; Zakrzewski, J; Żukowska-Szczechowska, E; Grzeszczak, W; Dominiczak, Anna F.

doi:10.1161/01.atv.0000113291.39267.0a

Cited by 66 publications

(65 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, there have been reports indicating that there exist associations between Y chromosome haplogroups and male infertility (Kuroki et al, 1999;Krausz et al, 2001;Lu et al, 2007;Yang et al, 2008;Puzuka et al, 2011;Ran et al, 2013;Sato et al, 2013), semen parameters (Sato et al, 2014), and prostate cancer (Ewis et al, 2006;Lindstr€ om et al, 2008;Wang et al, 2012) in some populations, including the Japanese. The Y chromosome haplogroup is also associated with several phenotypes other than male characteristics, including cardiovascular risk (Hiura et al, 2008;Bloomer et al, 2013;Kostrzewa et al, 2013), coronary artery disease (Charchar et al, 2012), lipids (Charchar et al, 2004;Russo et al, 2008), and blood pressure (Charchar et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Y chromosome haplogroup D2a1 is significantly associated with high levels of luteinizing hormone in Japanese men

et al. 2015

View full text Add to dashboard Cite

SUMMARYThe association between the Y chromosome haplogroup D2 and risk of azoospermia and low sperm motility has been previously studied, and it was indicated that haplogroups DE (YAP lineage) are associated with prostate cancer risk in Japanese males. Our assumption had been that Y chromosome haplogroups may be associated with sex hormone levels, because sex hormones have been deemed responsible for spermatogenesis and carcinogenesis. In this study, we assessed the association between Y chromosome haplogroups and sex hormone levels, including those of testosterone, sex hormone-binding globulin (SHBG), follicle-stimulating hormone (FSH), luteinizing hormone (LH), inhibin-B, and calculated free testosterone (cFT), in 901 young men from the general Japanese population (cohort 1) and 786 Japanese men of proven fertility (cohort 2). We found that the haplogroup D2a1 was significantly associated with high LH levels in a combined analysis involving two cohorts (b = 0.068, SE = 0.025, p = 0.0075), following correction for multiple testing. To date, this result is the first evidence that implicates Y chromosome haplogroups in an association with sex hormone levels.

show abstract

Section: Introductionmentioning

confidence: 99%

Y chromosome haplogroup D2a1 is significantly associated with high levels of luteinizing hormone in Japanese men

et al. 2015

View full text Add to dashboard Cite

show abstract

“…In addition, biologically meaningful relationships between sex steroids and markers of cardiovascular disease are likely to have their roots early in life, prior to the onset of typical clinical manifestations of atherosclerosis. Indeed, the previous observations provided evidence for an independent correlation between circulating concentrations of testosterone and high-density lipoprotein cholesterol (HDL-C) in young men from the YMCA study (4).…”

Section: Introductionmentioning

confidence: 91%

“…Consistently, the rates of death from cardiovascular diseases have been significantly higher among men than women in most age categories and across cohorts of different ethnicity (2). Genetic variation within the male-specific region of the Y chromosome (3)(4)(5) and dominance of androgens over estrogens (4,(6)(7) have been proposed as the major factors contributing to the male predisposition to cardiovascular disorders. However, several investigations have shown protective rather than detrimental effects of endogenous testosterone on cardiovascular system, at least in elderly men (8)(9)(10).…”

Section: Introductionmentioning

confidence: 94%

“…A sample of 933 men recruited in the Young Men Cardiovascular Association (YMCA) study (4) was included in the current analysis. In brief, the YMCA cohort consists of young, apparently healthy men recruited from randomly selected secondary schools of Silesia (in the south of Poland) (4) and phenotyped for several cardiovascular risk factors, as reported previously (4).…”

Section: Subjectsmentioning

confidence: 99%

“…In brief, the YMCA cohort consists of young, apparently healthy men recruited from randomly selected secondary schools of Silesia (in the south of Poland) (4) and phenotyped for several cardiovascular risk factors, as reported previously (4). Of 1157 subjects included in the Young Men Cardiovascular Association (YMCA) study (4), all men with available clinical, demographic data and plasma sample for hormonal analysis (933 -80.6% of the original YMCA cohort/) were used in the current investigation.…”

Section: Subjectsmentioning

confidence: 99%

See 2 more Smart Citations

Association between lipid profile and circulating concentrations of estrogens in young men

et al. 2009

Self Cite

View full text Add to dashboard Cite

Objectives-Men show higher rates of cardiovascular morbidity and mortality than premenopausal women and this sexual dimorphism may be related to sex-specific effects of sex steroids on cardiovascular risk factors. Unlike androgens, estrogens were not extensively investigated in relation to cardiovascular phenotypes in men.Methods-We examined associations of estradiol and estrone and their precursors (total testosterone and androstenedione) with traditional cardiovascular risk factors (lipids, blood pressure, body mass) in 933 young (median age -19 years), apparently healthy Polish men.Results-Total estradiol was associated with total cholesterol (p=0.006) and HDL-cholesterol (p<0.001) and estrone showed the strongest associations with both total cholesterol (p<0.001) and LDL-cholesterol (p<0.001) in the unadjusted ANOVA analysis. In the multivariable adjusted models in which other independent variables were held as constant one standard deviation increase in estradiol level was associated with 6%-standard deviation increase in total cholesterol (standardized B=0.06, p=0.038) and 6%-standard deviation decrease in p=0.036). An increase in estrone levels by one standard deviation was associated with respective 12%-and 13%-standard deviation increases in total cholesterol (standardized B=0.12, p<0.001) and LDL-cholesterol levels (standardized B=0.12, p<0.001) after controlling for other predictors of lipids. Estrone correlated linearly with androstenedione (r=0.28, p<0.001) but there was no correlation between estradiol and testosterone. Estrogens retained their independent associations with lipids after adjustment for their biochemical precursors in the multivariable analysis.Conclusions-Increased levels of estrogens are associated with unfavourable lipid profile in men and that this association is apparent early in life, before cardiovascular disease manifestations.

show abstract

Individualized medicine: Sex, hormones, genetics, and adverse drug reactions

Moyer

Matey

Miller

2019

Pharmacology Res & Perspec

View full text Add to dashboard Cite

Clinically relevant adverse drug reactions differ between men and women. The underlying physiological and pharmacological processes contributing to these differences are infrequently studied or reported. As gene expression, cellular regulatory pathways, and integrated physiological functions differ between females and males, aggregating data from combined groups of men and women obscures the ability to detect these differences. This paper summarizes how genetic sex, that is, the presence of sex chromosomes XY for male or XX for female, and the influence of sex hormones affect transporters, receptors, and enzymes involved in drug metabolism. Changing levels of sex steroids throughout life, including increases at puberty, changes with pregnancy, and decreases with age, may directly and indirectly affect drug absorption, distribution, metabolism, and elimination. The direct and indirect effects of sex steroids in the form of exogenous hormones such as those used in hormonal contraceptives, menopausal hormone treatments, transgender therapy, and over‐the‐counter performance enhancing drugs may interfere with metabolism of other pharmaceuticals, and these interactions may vary by dose, formulation, and mode of delivery (oral, injection, or transdermal) of the steroid hormones. Few drugs have sex‐specific labeling or dosing recommendations. Furthermore, there is limited literature evaluating how the circulating levels of sex steroids impact drug efficacy or adverse reactions. Such research is needed in order to improve the understanding of the impact of sex hormones on pharmacological therapies, particularly as medicine moves toward individualizing treatments.

show abstract

Association of the Human Y Chromosome with Cholesterol Levels in the General Population

Cited by 66 publications

References 33 publications

Y chromosome haplogroup D2a1 is significantly associated with high levels of luteinizing hormone in Japanese men

Y chromosome haplogroup D2a1 is significantly associated with high levels of luteinizing hormone in Japanese men

Association between lipid profile and circulating concentrations of estrogens in young men

Individualized medicine: Sex, hormones, genetics, and adverse drug reactions

Contact Info

Product

Resources

About