Association of the HLA-DRB1*01 allele with spontaneous viral clearance in an Irish cohort infected with hepatitis C virus via contaminated anti-D immunoglobulin

Barrett, Sharon; Ryan, Eleanor; Crowe, J.

doi:10.1016/s0168-8278(99)80249-9

Cited by 88 publications

(68 citation statements)

References 22 publications

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“…An association has been reported for HLA-DRB1*0101 with self-limiting infection in this cohort. 19,26 Thio et al 41 also observed an effect for DRB1*0101.…”

Section: Susceptibility To Persistent Hcv Infectionmentioning

confidence: 89%

Host genetic determinants in hepatitis C virus infection

2004

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In addition to viral and environmental/behavioural factors, host genetic diversity is believed to contribute to the spectrum of clinical outcomes in hepatitis C virus (HCV) infection. This paper reviews the literature with respect to studies of host genetic determinants of HCV outcome and attempts to highlight trends and synthesise findings. With respect to the susceptibility to HCV infection, several studies have replicated associations of the HLA class II alleles DQB1*0301 and DRB1*11 with selflimiting infection predominantly in Caucasian populations. Meta-analyses yielded summary estimates of 3.0 (95% CI: 1.8-4.8) and 2.5 (95% CI: 1.7-3.7) for the effects of DQB1*0301 and DRB1*11 on self-limiting HCV, respectively. Studies of genetics and the response to interferon-based therapies have largely concerned single-nucleotide polymorphisms and have been inconsistent. Regarding studies of genetics and the progression of HCV-related disease, there is a trend with DRB1*11 alleles and less severe disease. Studies of extrahepatic manifestations of chronic HCV have shown an association between DQB1*11 and DR3 with the formation of cryoglobulins. Some important initial observations have been made with respect to genetic determinants of HCV outcome. Replication studies are needed for many of these associations, as well as biological data on the function of many of these polymorphisms.

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“…An association has been reported for HLA-DRB1*0101 with self-limiting infection in this cohort. 19,26 Thio et al 41 also observed an effect for DRB1*0101.…”

Section: Susceptibility To Persistent Hcv Infectionmentioning

confidence: 89%

Host genetic determinants in hepatitis C virus infection

2004

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“…Indeed, studies of women who were accidentally infected with the same inoculum (contaminated immunoglobulin D antibody) showed that despite receiving the same virus strain, viral diversity could not account for the dichotomy in outcome (clearance versus persistence). [29][30][31][32][33] Thus, differences in the host response were more likely to be the determining factor. Several important insights into this crossroad of viral and host genetics have been forthcoming from studies in human immunodeficiency virus (HIV) infection.…”

Section: Introductionmentioning

confidence: 99%

Impact of the genetic restriction of virus-specific T-cell responses in hepatitis C virus infection

Thimme

2007

Genes Immun

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The immunobiology of hepatitis C virus (HCV) is significantly influenced by the host immune response to the virus, especially by virus-specific T-cell responses. Virus-specific T cells are restricted by human leucocyte antigen class I and II molecules. Of note, associations between these polymorphic loci and outcome and course of HCV infection have been reported in large and well-documented cohorts. This review will briefly summarize these studies and focus especially on the immunological and virological basis for the reported associations. The outcome and course of HCV infection is most likely determined by a complex interplay of genetic, immunological and virological factors. A better understanding of these host-virus interactions is essential not only to gain better insights into the mechanisms of viral clearance and persistence but also for the development of new antiviral vaccine strategies.

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“…HLA-A*03, HLA-B*27 and HLA-Cw*01 occurred more frequently in those who cleared the virus [14], while the HLA-A*11, Cw*04 haplotype was associated with persistent infection [15]. The HLA Class II allele DRB1*01 was associated with spontaneous viral clearance [16]. Previous work has demonstrated that CD209 has a crucial role in determining the outcome of infection with Dengue virus, which like HCV is a member of the Flaviviridae family of viruses [7].…”

Section: Discussionmentioning

confidence: 95%

Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection

Ryan¹,

Dring²,

Ryan³

et al. 2010

Human Immunology

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CD209, a c-type lectin expressed by dendritic cells (DCs) acts as a pathogen recognition receptor. A single nucleotide polymorphism (SNP) in the promoter region of CD209 (-336 A/G; rs4804803) affects transcription and is associated with the severity of Tuberculosis and Dengue fever. As CD209 binds Hepatitis C Virus (HCV) glycoprotein-E2, we investigated this SNP in the context of chronic HCV infection.131 Irish women who had received HCV contaminated Anti-D immunoglobulin and 79 healthy controls were genotyped. We found no association between rs4804803 and the risk of HCV chronicity. However, of those with chronic infection, possession of at least one g-allele was associated with more advanced liver disease, with significantly higher liver fibrosis scores and levels of alanine transaminase (ALT) observed. We conclude that rs4804803, a SNP in the CD209 promoter contributes to the severity of liver disease in chronic HCV infection.

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Association of the HLA-DRB1*01 allele with spontaneous viral clearance in an Irish cohort infected with hepatitis C virus via contaminated anti-D immunoglobulin

Cited by 88 publications

References 22 publications

Host genetic determinants in hepatitis C virus infection

Host genetic determinants in hepatitis C virus infection

Impact of the genetic restriction of virus-specific T-cell responses in hepatitis C virus infection

Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection

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