Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection

Ryan, Eleanor; Dring, Megan; Ryan, Cliona M.; McNulty, Carol; Stevenson, Nigel J.; Lawless, Matthew W.; Crowe, J.; Nolan, Niamh; Hegarty, John E.; O’Farrelly, Cliona

doi:10.1016/j.humimm.2010.05.007

Cited by 29 publications

(25 citation statements)

References 23 publications

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“…Human clinical trials aimed at investigating the efficiency of PD-1/PD-L1 modulation in a variety of diseases, including HCV infection, are underway. The polymorphisms of the pattern recognition receptor expression, such as CD209, in DCs correlated with liver fibrosis scores and levels of ALT, as shown by Ryan et al [46] in a longitudinal study setting. Conversely, the polymorphism of DC-SIGNR, which is a CD209 ligand, might affect HCV loads [47].…”

Section: Myeloid Dendritic Cellsmentioning

confidence: 63%

Dendritic cells in hepatitis C infection: can they (help) win the battle?

Dolganiuc

Szabó

2011

J Gastroenterol

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Infection with hepatitis C virus (HCV) is a public health problem; it establishes a chronic course in ~85% of infected patients and increases their risk for developing liver cirrhosis, hepatocellular carcinoma, and significant extrahepatic manifestations. The mechanisms of HCV persistence remain elusive and are largely related to inefficient clearance of the virus by the host immune system. Dendritic cells (DCs) are the most efficient inducers of immune responses; they are capable of triggering productive immunity and maintaining the state of tolerance to self- and non-self antigens. During the past decade, multiple research groups have focused on DCs, in hopes of unraveling an HCV-specific DC signature or DC-dependent mechanisms of antiviral immunity which would lead to a successful HCV elimination strategy. This review incorporates the latest update in the current status of knowledge on the role of DCs in anti-HCV immunity as it relates to several challenging questions: (a) the phenotype and function of diverse DC subsets in HCV-infected patients; (b) the characteristics of non-human HCV infection models from the DCs' point of view; (c) how can in vitro systems, ranging from HCV protein- or peptide-exposed DC to HCV protein-expressing DCs, and in vivo systems, ranging from HCV protein-expressing transgenic mice to HCV-infected non-human primates, be employed to dissect the role of DCs in triggering/maintaining a robust antiviral response; and (d) the prospect of DC-based strategy for managing and finding a cure for HCV infection.

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Section: Myeloid Dendritic Cellsmentioning

confidence: 63%

Dendritic cells in hepatitis C infection: can they (help) win the battle?

Dolganiuc

Szabó

2011

J Gastroenterol

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“…Similarly the -336G allele was associated with downregulation of the symptoms of a Dengue virus infection (de Oliveira et al, 2014). In addition, a SNP at -939 demonstrated an association with tuberculosis in Indonesian populations but not in Vietnamese populations (Kobayashi et al, 2011), whereas another SNP (rs4804803) increases liver disease severity during chronic HCV infection (Ryan et al, 2010). These data demonstrate the importance of DC-SIGN during various infectious diseases.…”

Section: Prrs In Health and Diseasementioning

confidence: 85%

International Union of Basic and Clinical Pharmacology. XCVI. Pattern Recognition Receptors in Health and Disease

et al. 2015

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“…In the population analyzed in this study, the observed allele frequency was 20.2%, which is similar to the frequency observed in European countries (P > 0.05). In an Irish population, for example, the frequency of allele -336G is 19% (Ryan et al, 2010). In Spain, the frequency varies between 20.8% in the north to 22% in the south (Núñez et al, 2006;DieguezGonzalez et al, 2009).…”

Section: Discussionmentioning

confidence: 98%

“…In this study, we described the frequency of CD209 SNP -336A/G in a population from Piauí State, located in northeastern Brazil. This SNP has been associated with infectious diseases of different etiologies, notably those of viral origin (Kashima et al, 2009;Chan et al, 2010;Ryan et al, 2010;Wang et al, 2011;Barkhash et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…One study found that allele -336G was associated with higher expression of DC-SIGN on the surface of DCs (Wang et al, 2011). In this context, SNP -336A/G in CD209 could confer greater protection or increased susceptibility to certain infectious diseases (Barreiro et al, 2006;Kashima et al, 2009;Chan et al, 2010;Ryan et al, 2010). However, because some studies have reported contradictory results, the actual effect of SNP -336A/G remains inconclusive in some cases (Wang et al, 2011;Alagarasu et al, 2013;Oliveira et al, 2014), emphasizing the need for validation studies in different populations.…”

Section: Discussionmentioning

confidence: 99%

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Frequency of SNP -336A/G in the promoter region of CD209 in a population from northeastern Brazil

Pn¹,

Ferreira-Fernandes²,

Js³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Dendritic cells (DCs) mediate the initiation of the immune response against a variety of pathogens. The DC-SIGN receptor is encoded by the gene CD209 and is expressed on the surface of DCs. It binds to mannose-rich carbohydrates and enables the recognition of bacteria, fungi, parasites, and viruses. SNP -336A/G in the promoter region of CD209 influences the expression of the DC-SIGN receptor. Several studies have associated this SNP with an increased susceptibility to infectious diseases and the development of more severe forms of disease. Therefore, the aim of this study was to determine the prevalence of SNP -336A/G in a population from northeastern Brazil. We analyzed 181 individuals from the general population of Parnaíba, Piauí, Brazil, of which 37% were men and 63% were women. SNP -336A/G was detected by polymerase chain reaction and treatment with the restriction enzyme MscI and visualized by electrophoresis on an 8% polyacrylamide gel stained with silver nitrate. Of the individuals analyzed, 116 (64.1%) were homozygous AA, 57 (31.5%) were heterozygous (AG), and 8 (4.4%) were homozygous GG. The allele frequency of -336G was 20.2%. Genotype frequencies were in Hardy-Weinberg equilibrium. To the best of our knowledge, this is the first report to describe the frequency of the CD209 SNP -336A/G in a population in the State of Piauí. Further studies are needed to determine the relationship between this SNP and the vulnerability of this population to major infectious diseases.

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Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection

Cited by 29 publications

References 23 publications

Dendritic cells in hepatitis C infection: can they (help) win the battle?

Dendritic cells in hepatitis C infection: can they (help) win the battle?

International Union of Basic and Clinical Pharmacology. XCVI. Pattern Recognition Receptors in Health and Disease

Frequency of SNP -336A/G in the promoter region of CD209 in a population from northeastern Brazil

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