Association of the HindIII Lipoprotein Lipase Gene Polymorphism with the Development of the Non-Biliary Acute Pancreatitis: a Pilot Study

Самгина, Т. А.; Бушуева, О. Ю.; Назаренко, П. М.; Polonikov, Alexey

doi:10.1007/s10517-016-3350-1

Cited by 2 publications

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References 10 publications

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“…The accurate genetic and molecular or any other mechanism which affects the LPL and human disease is poorly understood and LDL was interrelated towards certain heterogenous disorders which involve limited cardiovascular disorders ( Hartley et al, 2020 ). The rs320 polymorphism has been studied globally in CAD, stroke, dyslipidemia ( Javorsky et al, 2007 , Nejati et al, 2018 , Sagoo et al, 2008 , Samgina et al, 2016 , Tetik Vardarli et al, 2017 , Velasquez Pereira et al, 2016 ) and this polymorphism is located between the intron 6–8 and important role of rs320 polymorphism could elevate the atherosclerosis risk through influencing plasma lipid levels ( Nagrani et al, 2020 ). LPL variants, Ser447stop (S447X) are connected to a decline in LPL activity while Asn291Ser (N291S) and Asp9Asn (D9N) with an elevation in LPL activity.…”

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confidence: 99%

Association between HindIII (rs320) variant in the lipoprotein lipase gene and the presence of coronary artery disease and stroke among the Saudi population

Bogari

Aljohani

Dannoun

et al. 2020

Saudi Journal of Biological Sciences

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Lipoprotein Lipase (LPL) is known to be a key enzyme for lipid metabolism specifically in an enzymatic glycoprotein which provide tissues without fatty-acids and eliminates triglycerides (TG) by the circulation. Mutations in LPL were proven to cause alteration in fractions within lipoprotein, causing the development of atherosclerosis which predispose to weakening coronary artery disease (CAD) and stroke. We examined the linkage between genetic variant Hind III in LPL on lipoprotein fractions, stroke occurrences and CAD. In this case-control study, we have recruited 315 CAD cases and 205 age-matched controls. A total of 520 genomic DNA was digested with the purified PCR products for restriction fragment length polymorphism with Hind III restriction enzyme. The distribution of genotypes in a decreasing order were TT, 148 (47%), GT 135 (42.9%) and GG 32 (10.2%) in CAD groups of the study while the pattern in controls were GT 91 (44.4%), TT 86 (42%) and GG 28 (13.7%). None of all the allele or genotype frequencies were found to be significant in our study (p greater than 0.05), while the biochemical levels for both TG and LDL-c were shown to be prone in CAD patients when compare with the controls. Furthermore, the occurence of strokes were more in CAD groups vs. controls: 72 (22.9%) vs. 7 (3.4%) [p 0.000]. This could indicate the influence of Hind III variant on plasma lipid levels, and the possibility of considering it a risk factor for atherosclerosis leading to CAD and stroke occurrence.

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Section: Introductionmentioning

confidence: 99%

Association between HindIII (rs320) variant in the lipoprotein lipase gene and the presence of coronary artery disease and stroke among the Saudi population

Bogari

Aljohani

Dannoun

et al. 2020

Saudi Journal of Biological Sciences

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“…Острый алкогольно-алиментарный панкреатит (ОААП) является мультифакториальным заболеванием, обусловленным сочетанным влиянием генетических и средовых факторов [1]. Ведущую роль в патогенезе тяжелого течения заболевания отводят ферментам поджелудочной железы и цитокинам [2][3][4][5].…”

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The risk of severe acute pancreatitis depending on the genetic predisposition and diet

Samgina,

Kochetova

2024

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The aim of the study: to determine the influence of genetic predisposition and diet on the risk of severe acute pancreatitis (АР). Materials and methods. The results of diagnostics and treatment of 547 patients with acute pancreatitis were analyzed, 97 of them had a severe АР. Patients' blood DNA samples were used as research material. Detailed questionnaire on nutrition was carried out, the qualitative and quantitative composition of the food consumed was assessed. Genomic DNA was isolated using the standard PCE method. Genotyping was performed on a MALDI-TOF MassARRAY-4 analyzer. The role of the following polymorphic variants was studied: SPINK1 C>T (rs6580502), PRSS1 C>T (rs10273639), CFTR A>G (rs213950), TNF -308 G>A (rs1800629), IL1B A>G (rs16944), IL5 A>G (rs2069812), IL6 G>C (rs1800795), IL10 T>C (rs1800896), CETP G>A (rs708272) and LPL T>G (rs320). Statistical analysis was performed using SNPStats and Statistica 10.0 software. Results. In our study, we found that carriers of A/A rs2069812 IL5, G/G-G/C rs1800795 IL6 and T/T rs320 LPL genotypes increased the risk of severe acute pancreatitis. Alcohol abuse increases the risk of severe disease in carriers of T/T SPINK1 (rs6580502) and A/A CFTR (rs213950) genotypes. Constant exposure to alimentary risk factor manifested by increased consumption of fatty foods increases the risk in carriers of G/A-A/A rs 16944 IL1B, reduced protein and carbohydrate intake with food - in carriers of G/A-A/A rs2069812 IL5, carbohydrate - in carriers of G/A-A/A rs708272 CETP. Conclusion. Predictive diagnostics plays an important role in the prevention of severe acute pancreatitis, eliminating the effects of risk factors in carriers of genotypes associated with a severe course of the disease will make it possible to achieve positive success in the prevention of AP, to reduce the frequency of complications and the development of its severe course, to reduce mortality.

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Association of the HindIII Lipoprotein Lipase Gene Polymorphism with the Development of the Non-Biliary Acute Pancreatitis: a Pilot Study

Cited by 2 publications

References 10 publications

Association between HindIII (rs320) variant in the lipoprotein lipase gene and the presence of coronary artery disease and stroke among the Saudi population

Association between HindIII (rs320) variant in the lipoprotein lipase gene and the presence of coronary artery disease and stroke among the Saudi population

The risk of severe acute pancreatitis depending on the genetic predisposition and diet

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