Association of the GSTT1 polymorphism in upper aerodigestive tract cancer with tobacco smoking

Silva, T.M.; Marques, Caroline; Filho, Marcílio Ferreira Marques; Marques, Agostinho; Pietro, Giuliano Di; Rios-Santos, Fabrício

doi:10.4238/2014.january.21.22

Cited by 8 publications

(8 citation statements)

References 36 publications

(39 reference statements)

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“…17 This same pattern was verified in our findings, since a higher OS rate was observed among the individuals with GSTT1 rs71748309 nonnull genotype, which was a risk factor for HNSCC in a previous case-control study carried out in the same population of present study. 14 In the present study, no significant association was observed between the polymorphisms GSTM1 rs4025935 null and CYP1A1 rs1048943 MspI and the OS of patients with HNSCC. A similar result was reported in a study conducted in the southeastern region of Brazil involving 153 patients diagnosed with HNSCC.…”

Section: Discussioncontrasting

confidence: 72%

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Polymorphisms in biotransformation and DNA repair genes, and survival on head and neck squamous cell carcinoma

Novais¹,

Bezerra²,

Barbosa³

et al. 2020

BJOncology

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This study analyzed the association between xenobiotic metabolism and DNA repair gene polymorphisms and overall survival (OS) and disease-free survival (DFS) in patients diagnosed with HNSCC in a Brazilian population. Methods: Retrospective study included 91 patients with a confirmed diagnosis of HNSCC. A total of 7 genes were analyzed: XRCC1, HOGG1, CYP1A1, GSTM1, GSTT1, GSTP1 and NAT2. Results: Regarding OS, the largest mean differences were observed comparing GSTT1 rs71748309 null and GSTT1 rs71748309 non-null genotypes (p=0.050). In the gene-gene interaction analysis, the higher difference to OS was observed to the combined genotypes of the GSTM1 rs4025935 and GSTT1 rs71748309 (p=0.286). Regarding DFS, the largest mean differences were observed comparing GSTT1 rs71748309 null and GSTT1 rs71748309 non-null genotypes (p=0.060) and to the combined genotypes of the GSTM1 rs4025935 and GSTT1 rs71748309 (p=0.313). Conclusion: None of the polymorphisms evaluated in xenobiotic metabolism or DNA repair genes were significantly associated with HNSCC survival in our population. Confirmation of these results in larger studies is required.

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Section: Discussioncontrasting

confidence: 72%

“…were enrolled. All individuals signed the consent form approved by the Institutional Ethics Committee of the State University of Santa Cruz -UESC (Protocol Number: 134/2007).From each volunteer, three milliliters of peripheral blood were obtained that was later used in the extraction of genomic DNA 14.…”

mentioning

confidence: 99%

Polymorphisms in biotransformation and DNA repair genes, and survival on head and neck squamous cell carcinoma

Novais¹,

Bezerra²,

Barbosa³

et al. 2020

BJOncology

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show abstract

“…The GSTT1 null genotype was less frequent among the investigated patients and healthy individuals and may indicate a reduced risk for cancer development. Similarly, studies on patients with HNSCC, such as the study carried in Brazilian population observed a lower frequency of the GSTT1 null genotype (16.8%) in healthy subjects (Brunialti, 2009), while Silva et al found a higher frequency of the GSTT1 positive genotype among healthy individuals (24.1%) (Silva et al, 2014).…”

Section: Discussionmentioning

confidence: 88%

Glutathione S-transferase Polymorphisms in Head and Neck Squamous Cell Carcinoma Treated with Chemotherapy and/or Radiotherapy

Maniglia

Russo

Biselli-Chicote

et al. 2020

Asian Pac J Cancer Prev

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Background/Aim: The Glutathione S-transferases (GSTs) are important carcinogen-metabolizing enzymes. Polymorphisms involved in these enzymes can modulate the development and treatment of head and neck cancer. To investigate the association of GSTs polymorphisms with head and neck cancer and risk factors, clinical-pathological features, and survival time of the patients treated with chemotherapy and/or radiotherapy. Methods: The GST gene polymorphisms were evaluated in 197 cases and 514 controls by PCR-RFLP-Polymerase Chain Reaction Restriction Fragment Length Polymorphism. Results: The GSTP-313 was associated with a decreased risk for HNSCC (p=0.050). The GSTP1 haplotype analysis revealed a higher frequency of the AC and AT haplotypes in the case group than in the control group (p=0.013 and p=0.019, respectively), and the opposite for G-C haplotype (p = 0.015). Yet, the different combinations between the genotypes were associated with an increased risk of cancer. The study showed no association between the polymorphisms and primary tumor site, clinical-pathological characteristics, treatment (chemotherapy and/or radiotherapy) and survival time of the patients. Conclusion: The GST polymorphisms combination showed an increased risk for carcinogenesis, and studies with larger casuistry can contribute to the clarification of the role in individual patient differences for the response to chemotherapy and/or radiotherapy and identify biomarkers of susceptibility.

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“…Previous studies have indicated that GSTP1 polymorphism is associated with various kinds of cancers, such as acute myeloid leukemia, lung cancer, breast cancer, colorectal cancer, brain tumor, and esophageal cancer (Cong et al, 2014;Silva et al, 2014;Song et al, 2014;Jaramillo-Rangel et al, 2015;Nasr et al, 2015;Sharma et al, 2015;Soto-Quintana et al, 2015;Zhou et al, 2015;Geng et al, 2016;Khabaz et al, 2016;Kimi et al, 2016). Several studies have also reported that GSTP1 polymorphism is associated with risk of gastric cancer in various populations, but the results were inconsistent (Nguyen et al, 2010;Zhang et al, 2011;Bao et al, 2012;García-González et al, 2012;Jing et al, 2012;Zhang et al, 2012;Ma et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer risk, and their interactions with environmental factors

2017

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ABSTRACT. Glutathione S-transferase (GST) is an important member of phase II metabolic enzymes; GSTM1, GSTT1, and GSTP1 belong to three subfamilies of the GST enzyme. Polymorphisms in GSTM1, GSTT1, and GSTP1 could affect detoxification processes, and increase individuals' susceptibility to cancers. We aimed to investigate the association between GSTM1, GSTT1, and GSTP1 polymorphisms and the risk of gastric cancer in a Chinese population. In addition, we also examined the effect of gene-environmental interactions, and their effect on risk of this cancer. Between July 2013 and June 2015, we recruited 242 gastric cancer patients and 396 healthy controls for our study. Polymerase chain reaction-restriction fragment length polymorphism analysis was used to characterize genetic polymorphisms in GSTM1, GSTT1, and GSTP1. We observed that the Val/Val genotype of GSTP1 was associated with increased risk of gastric cancer when compared with the Ile/Ile genotype (OR = 3.19, 95%CI = 1.84-5.56). Moreover, the Val allele of GSTP1 was associated with higher susceptibility to gastric cancer as compared with the Ile allele (OR = 1.52, 95%CI = 1.19-1.93). However, GSTM1 and GSTT1 polymorphisms did not affect the development of gastric cancer. In conclusion, our study indicated that GSTP1 Ile105Val, but not GSTM1 and GSTT1 polymorphisms, was associated with risk of gastric cancer.

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Association of the GSTT1 polymorphism in upper aerodigestive tract cancer with tobacco smoking

Cited by 8 publications

References 36 publications

Polymorphisms in biotransformation and DNA repair genes, and survival on head and neck squamous cell carcinoma

Polymorphisms in biotransformation and DNA repair genes, and survival on head and neck squamous cell carcinoma

Glutathione S-transferase Polymorphisms in Head and Neck Squamous Cell Carcinoma Treated with Chemotherapy and/or Radiotherapy

Association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer risk, and their interactions with environmental factors

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