Association of the Glutathione S-Transferase M1, T1 Polymorphisms with Cancer: Evidence from a Meta-Analysis

Fang, Jianzheng; Wang, Shangqian; Zhang, Shengli; Su, Shifeng; Song, Zhijun; Deng, Yunfei; Cui, He; Wang, Hainan; Zeng, Yi; Qian, Ji; Gu, Jingyu; Liu, Bianjiang; Li, Pengchao; Zhang, Rui; Liu, Xinnong; Wang, Zengjun

doi:10.1371/journal.pone.0078707

Cited by 18 publications

(18 citation statements)

References 30 publications

(25 reference statements)

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“…Overall there was an eight-fold difference in urinary SPMA at baseline between subjects who had both or neither GSTM1 and GSTT1 genes. The deletion polymorphism of GSTM1 and GSTT1 genes is associated with increased risk of many malignancies including lung cancer (33), particularly in smokers (34). The present study demonstrates that smokers lacking both GSTM1 and GSTT1 genes may derive the most benefit from intake of PEITC due to their increased detoxification of carcinogens and toxicants.…”

Section: Discussionmentioning

confidence: 99%

2-Phenethyl Isothiocyanate, Glutathione S-transferase M1 and T1 Polymorphisms, and Detoxification of Volatile Organic Carcinogens and Toxicants in Tobacco Smoke

Yuan

Murphy

Stepanov

et al. 2016

Cancer Prevention Research

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Cigarette smoke contains relatively large quantities of volatile organic toxicants or carcinogens such as benzene, acrolein and crotonaldehyde. Among their detoxification products are mercapturic acids formed from glutathione conjugation, catalyzed in part by glutathione S-transferases (GST). A randomized phase 2 clinical trial with a crossover design was conducted to evaluate the effect of 2-phenethyl isothiocyanate (PEITC), a natural product formed from gluconasturtiin in certain cruciferous vegetables, on the detoxification of benzene, acrolein, and crotonaldehyde in 82 cigarette smokers. Urinary mercapturic acids of benzene, acrolein and crotonaldehyde at baseline and during treatment were quantified. Overall, oral PEITC supplementation increased the mercapturic acid formed from benzene by 24.6% (P=0.002) and acrolein by 15.1% (P=0.005), but had no effect on crotonaldehyde. A remarkably stronger effect was observed among subjects with the null genotype of both GSTM1 and GSTT1: in these individuals PEITC increased the detoxification metabolite of benzene by 95.4% (P<0.001), of acrolein by 32.7% (P=0.034), and of crotonaldehyde by 29.8% (P=0.006). In contrast, PEITC had no effect on these mercapturic acids in smokers possessing both genes. PEITC had no effect on the urinary oxidative stress biomarker 8-iso-prostaglandin F2α or the inflammation biomarker prostaglandin E2 metabolite. This trial demonstrates an important role of PEITC in detoxification of environmental carcinogens and toxicants which also occur in cigarette smoke. The selective effect of PEITC on detoxification in subjects lacking both GSTM1 and GSTT1 genes supports the epidemiological findings of stronger protection by dietary isothiocyanates against the development of lung cancer in such individuals.

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Section: Discussionmentioning

confidence: 99%

2-Phenethyl Isothiocyanate, Glutathione S-transferase M1 and T1 Polymorphisms, and Detoxification of Volatile Organic Carcinogens and Toxicants in Tobacco Smoke

Yuan

Murphy

Stepanov

et al. 2016

Cancer Prevention Research

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“…The motivation for this study was to determine the association between GST polymorphic genes (GSTM1 and GSTT1) and susceptibility to breast cancer in Ghanaian population using an available small sample (n=56). Glutathione S-transferase gene polymorphism has widely been studied in several disease conditions but conflicting results have been reported [25]. In this study, prevalence of GSTT1 null was higher in breast cancer patients and was strongly associated with the disease.…”

Section: Discussionmentioning

confidence: 64%

“…A meta-analysis and case-control studies revealed a strong association between GSTT1 null and breast cancer [25,26]. However, no association was reported between breast cancer and GSTM1 null [27,28].…”

Section: Discussionmentioning

confidence: 99%

Glutathione S-Transferase T1 and M1 Gene Polymorphisms among Breast Cancer Susceptible Ghanaians

Arko-Boham¹,

Tagoe²,

BerniceAdjorogbe³

et al. 2017

Clinical-Investigation

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“…Golka et al 34 discovered a higher risk of BCa among former hard coal miners in a former area of coal, iron and steel industries in Dortmund, Germany, 70% of BCa cases were attributed to glutathione S-transferase M1 (GSTM1) negative. From the results of a meta-analysis conducted byFang et al 40 based on 506 casecontrol studies GSTM1 was associated with a significantly increased risk in cancer especially in smokers (OR=1.17; 95%CI=1.14-1.21). Indicating that smoking increases the production of oxidative stress, especially in people carrying GSTM1 null genotype.These individuals are more prone to gene damage and hence increases the risk of cancer.…”

Section: Discussionmentioning

confidence: 99%

Occupational exposure as risk factor for kidney and bladder cancer: a systematic review and meta-analysis

Deb¹,

Okechukwu²,

Emara³

et al. 2019

UNOAJ

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Background: Occupational exposure plays a huge role in the epidemiology, pathogenesis and prevalence of kidney cancer (KCa) and bladder cancer (BCa) worldwide. Objective: The aim of this study was to analyze qualitatively and quantitatively the association between occupational exposure and risk of KCa and BCa. Method: We identified peer-reviewed articles published in English by searching PubMed, Embase, Surveillance, Epidemiology, and End Results (SEER) and Cochrane databases. We selected articles published between January 2018 to May 2019. We summed up all relative risk estimates to ensure accuracy, comprehensiveness and maximize statistical power given the low absolute occupational risk of KCa, occupational risk of BCa and standardized incidence ratios (SIRs). We reported this systematic review and meta-analysis in accordance with the Preferred Reporting Items for Systematic Reviews and metaanalyses (PRISMA) checklist. Quantitative analyzes was performed using Comprehensive Meta-Analysis version 3 (Biostat, Inc, Englewood, New Jersey, USA). Results:We found no significant association between occupational exposure and KCa (OR 1.04, 95% CI: 0.94-1.34), but there was a significant association between occupational exposure and BCa (OR 1.54, 95% CI: 1.44-1.75). Conclusion:From the result of our qualitative and quantitative analysis there was no significant association between occupational exposure and KCa whereas there was a significant association between occupational exposure and BCa.

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Association of the Glutathione S-Transferase M1, T1 Polymorphisms with Cancer: Evidence from a Meta-Analysis

Cited by 18 publications

References 30 publications

2-Phenethyl Isothiocyanate, Glutathione S-transferase M1 and T1 Polymorphisms, and Detoxification of Volatile Organic Carcinogens and Toxicants in Tobacco Smoke

2-Phenethyl Isothiocyanate, Glutathione S-transferase M1 and T1 Polymorphisms, and Detoxification of Volatile Organic Carcinogens and Toxicants in Tobacco Smoke

Glutathione S-Transferase T1 and M1 Gene Polymorphisms among Breast Cancer Susceptible Ghanaians

Occupational exposure as risk factor for kidney and bladder cancer: a systematic review and meta-analysis

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