Association of the FTO (rs9939609) and MC4R (rs17782313) gene polymorphisms with maternal body weight during pregnancy

Martins, Maisa Cruz; Trujillo, Janet; Farias, Dayana Rodrigues; Struchiner, Cláudio J.; Kac, Gilberto

doi:10.1016/j.nut.2016.04.009

Cited by 20 publications

(36 citation statements)

References 32 publications

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“…Nonetheless, few studies tried to establish an association between the role of FTO rs9939609 polymorphism in determining the risk of obesity and gestational age, GWG, and the same risk in newborns, respectively. Martins et al [51] noticed that the AA genotype of FTO rs9939609 gene polymorphism is positively associated with weight before birth, without being associated to GWG or postpartum weight. In our study the variant allele was also predominant in pregnant women (63.10%), in comparison with only 52.10% of the newborns.…”

Section: Discussionmentioning

confidence: 99%

The FTO rs9939609 and LEPR rs1137101 mothers–newborns gene polymorphisms and maternal fat mass index effects on anthropometric characteristics in newborns

et al. 2016

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The aim of this study was to assess the impact of mothers’ and newborns’ fat mass and obesity-associated gene (FTO) rs9939609 and leptin receptor (LEPR) rs1137101 gene polymorphisms on neonatal anthropometric parameters in order to identify a potential risk for developing obesity.We performed a cross-sectional study on 355 mother–newborn couples in an Obstetrics Gynecology Tertiary Hospital from Romania, evaluated with regard to anthropometric parameters, clinical and laboratory parameters besides 2 genetic polymorphisms (FTO rs9939609 and LEPR rs1137101).Newborns with mothers carrying variant AT or AA genotype for FTO rs9939609 presented lower BMI (P = 0.012) and lower MUAC (P = 0.029). There was a significant interaction effect between newborn and mother LEPR rs1137101 polymorphism on birth weight (P = 0.009) and BMI (P = 0.007). We noticed significantly increased birth weight and BMI in newborns carriers of AG + GG genotype, coming from mothers with AA genotype (P = 0.006). There was no evidence of significant interaction effect between newborn and mother FTO rs9939609 polymorphism on the studied anthropometrical data (P > 0.05). In addition, lower BMI scores (P = 0.042) were observed in newborns carriers of TT genotype whose mothers had AA + AT genotype. Lower MUAC scores (P = 0.041) were noticed in newborns carriers of AA + AT genotype whose mothers had AA + AT genotype for FTO rs9939609 gene polymorphism. Newborns carriers of the AG + GG genotype (P = 0.003) of LEPR rs1137101 coming from mothers with increased FMI (upper tertile) had significantly increased BMIs.Presence of the variant A allele of FTO rs9939609 polymorphism in mothers decreased BMI and MUAC in newborns. The impact of LEPR rs1137101 polymorphism on BMI and birth weight in newborns differed depending on the presence/absence of the dominant LEPR allele in mothers. In addition, we noticed that maternal FMI presented a significant positive effect on newborns’ BMI by changing the effect of LEPR rs1137101.We can conclude that mothers’ FTO rs9939609 and LEPR rs1137101 gene polymorphisms presented an impact on birth weight and newborns’ BMI, therefore being involved in the newborns’ nutritional status and in the design of a potential protocol.

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Section: Discussionmentioning

confidence: 99%

The FTO rs9939609 and LEPR rs1137101 mothers–newborns gene polymorphisms and maternal fat mass index effects on anthropometric characteristics in newborns

et al. 2016

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“…The FTO rs9939609 predisposes to childhood, adult (42,43) and pregnancy obesity (44). The FTO rs1421085 polymorphism is associated with obesity in adults and in European and Chinese children (45) and with obesity and T2DM in African Americans (46).…”

Section: Fto Rs1421085 Polymorphismmentioning

confidence: 99%

Type 2 diabetes-associated genetic variants of FTO, LEPR, PPARg, and TCF7L2 in gestational diabetes in a Brazilian population

Anghebem-Oliveira

Martins

Alberton

et al. 2017

Arch. Endocrinol. Metab.

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Objective: Gestational diabetes mellitus (GDM) is a metabolic disorder that shares pathophysiologic features with type 2 diabetes mellitus. The aim of this study was to investigate the association of the polymorphisms fat mass and obesity-associated (FTO) rs1421085, leptin receptor (LEPR) rs1137100, rs1137101, peroxisome proliferator-activated receptor gamma (PPARg) rs1801282, and transcription factor 7-like 2 (TCF7L2) rs7901695 with GDM. Subjects and methods: 252 unrelated Euro-Brazilian pregnant women were classified into two groups according to the 2015 criteria of the American and Brazilian Diabetes Association: healthy pregnant women (n = 125) and pregnant women with GDM (n = 127), matched by age. The polymorphisms were genotyped using fluorescent probes (TaqMan ® ). Results: All groups were in Hardy-Weinberg equilibrium. The genotype and allele frequencies of the studied polymorphisms did not show significant differences between the groups (P > 0.05). In the healthy and GDM groups, the C allele frequencies (95% CI) of the FTO rs1421085 polymorphism were 36.8% [31-43%]

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Section: Discussionmentioning

confidence: 93%

“…Regarding the pre‐pregnancy period, other authors have also reported higher weight and BMI among women carrying the AA genotype (Lawlor et al, ; Martins et al, ; Wehby and von Hinke Kessler Scholder, ). A study that investigated the association between maternal characteristics and the AA genotype of FTO ‐rs9939609 gene polymorphism in 136 Brazilian women showed 8.9 kg higher weight and 3.4 kg/m 2 higher BMI (Martins et al, ). Our results showed that women carrying the risk allele were 3.22‐4.24 kg heavier among the follow‐ups than those carrying the wild‐type genotype, values higher than those reported in other studies (Celis‐Morales et al, ; Liu et al, ).…”

Section: Discussionmentioning

confidence: 93%

“…The risk allele (“A”) of the FTO‐ rs9939609 polymorphism is associated with increased odds of being either overweight or obese (Celis‐Morales et al, ; Emond et al, ; Frayling et al, ; Liu et al, ; Lopez‐Bermejo et al, ; Oyeyemi et al, ; Peng et al, ; Ramos et al, ; Yang et al, ). Studies on pregnant women suggest a positive association of the FTO ‐rs9939609 AA genotype with high pre‐pregnancy weight (Lawlor et al, ; Martins et al, ) and pre‐pregnancy BMI (Lawlor et al, ; Martins et al, ; Wehby and von Hinke Kessler Scholder, ), maternal obesity (Wehby and von Hinke Kessler Scholder, ), and excessive gestational weight gain (GWG) (Groth and Morrison‐Beedy, ). Nevertheless, to the best of our knowledge, there are no studies evaluating the association of FTO gene polymorphisms with the reproductive transition from the pre‐pregnancy period to 4 years after pregnancy.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association between FTO gene polymorphism and excess body weight in women from before to after pregnancy: A cohort study

Kroll

França

Mastroeni

2018

American J Hum Biol

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Association of the FTO (rs9939609) and MC4R (rs17782313) gene polymorphisms with maternal body weight during pregnancy

Cited by 20 publications

References 32 publications

The FTO rs9939609 and LEPR rs1137101 mothers–newborns gene polymorphisms and maternal fat mass index effects on anthropometric characteristics in newborns

The FTO rs9939609 and LEPR rs1137101 mothers–newborns gene polymorphisms and maternal fat mass index effects on anthropometric characteristics in newborns

Type 2 diabetes-associated genetic variants of FTO, LEPR, PPARg, and TCF7L2 in gestational diabetes in a Brazilian population

Association between FTO gene polymorphism and excess body weight in women from before to after pregnancy: A cohort study

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