Association of the Composite Inflammatory Biomarker GlycA, with Exercise‐Induced Changes in Body Habitus in Men and Women with Prediabetes

Bartlett, David B.; Slentz, Cris A.; Connelly, Margery A.; Piner, Lucy W.; Willis, Leslie H.; Bateman, Lori A.; Granville, Esther O.; Bales, Connie W.; Huffman, Kim M.; Kraus, William E.

doi:10.1155/2017/5608287

Cited by 22 publications

(23 citation statements)

References 79 publications

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“…Barlett et al evaluated how an exercise-based lifestyle or exercise plus diet interventions for 6 months modulate GlycA in sedentary adults with prediabetes. Their results showed a reduction in GlycA levels, which they associated with a decrease in visceral adiposity [136]. GlycA has also been measured in obese patients undergoing bariatric surgery, which is the most effective therapy in cases of severe obesity.…”

Section: Metabolic Disordersmentioning

confidence: 98%

“…Only a few studies have described how these lifestyle changes contribute to reducing GlycA [98,135]. One study mentioned above with a 6-month intervention of resistance exercise alone or combined with diet in overweight and pre-diabetes individuals showed that GlycA levels decreased significantly by 2% [136]. Barber et al demonstrated significantly reduced plasma GlycA in 1568 individuals submitted to 14 exercise interventions even after adjustment for age, sex, race, baseline BMI, and baseline GlycA [137].…”

Section: Effect Of Exercisementioning

confidence: 99%

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Title: Human Serum/Plasma Glycoprotein Analysis by 1H-NMR, an Emerging Method of Inflammatory Assessment

Fuertes-Martín

Correig

Vallvé

et al. 2020

JCM

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Several studies suggest that variations in the concentration of plasma glycoproteins can influence cellular changes in a large number of diseases. In recent years, proton nuclear magnetic resonance (1H-NMR) has played a major role as an analytical tool for serum and plasma samples. In recent years, there is an increasing interest in the characterization of glycoproteins through 1H-NMR in order to search for reliable and robust biomarkers of disease. The objective of this review was to examine the existing studies in the literature related to the study of glycoproteins from an analytical and clinical point of view. There are currently several techniques to characterize circulating glycoproteins in serum or plasma, but in this review, we focus on 1H-NMR due to its great robustness and recent interest in its translation to the clinical setting. In fact, there is already a marker in H-NMR representing the acetyl groups of the glycoproteins, GlycA, which has been increasingly studied in clinical studies. A broad search of the literature was performed showing a general consensus that GlycA is a robust marker of systemic inflammation. The results also suggested that GlycA better captures systemic inflammation even more than C-reactive protein (CRP), a widely used classical inflammatory marker. The applications reviewed here demonstrated that GlycA was potentially a key biomarker in a wide range of diseases such as cancer, metabolic diseases, cardiovascular risk, and chronic inflammatory diseases among others. The profiling of glycoproteins through 1H-NMR launches an encouraging new paradigm for its future incorporation in clinical diagnosis.

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Section: Metabolic Disordersmentioning

confidence: 98%

Section: Effect Of Exercisementioning

confidence: 99%

Title: Human Serum/Plasma Glycoprotein Analysis by 1H-NMR, an Emerging Method of Inflammatory Assessment

Fuertes-Martín

Correig

Vallvé

et al. 2020

JCM

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“…55,56 GlycA concentrations are reduced by exercise, reductions in visceral adiposity, and anti-inflammatory drug treatments. 55,57,58 Interestingly, GlycA concentrations were reduced by the intervention in the control group but remained unchanged in the protein group. Currently, there is no obvious explanation for this observation.…”

Section: Discussionmentioning

confidence: 94%

Impact on cardiometabolic risk of a weight loss intervention with higher protein from lean red meat: Combined results of 2 randomized controlled trials in obese middle-aged and older adults

Starr

Connelly

Orenduff

et al. 2019

Journal of Clinical Lipidology

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and 175.0 meters), and fasting plasma glucose (27.5 and 26.2 mg/dL), respectively. At endpoint, protein group had significantly (P # .05) lower triglycerides (217.3 mg/dL), large very-low-density lipoprotein particle concentration (VLDL-P; 21.2 nmol/L), total low-density lipoprotein particle concentration (LDL-P; 267.8 nmol/L), small LDL-P (259.4 nmol/L) and lipoprotein insulin resistance index (25.9), whereas control group had significantly (P # .05) lower GlycA (213.1 mmol/L), total VLDL-P (27.9 nmol/L), and small VLDL-P (27.0 nmol/L). Differences between groups were observed for small VLDL-P (P 5 .02) and protein intake (P , .0001). CONCLUSIONS: These findings suggest that a hypocaloric diet with either traditional (0.8 g/kg BW/ d) or higher protein (1.2 g/kg BW/d; predominantly from lean red meat) content improves risk markers of cardiovascular disease and type II diabetes in obese middle-aged and older adults. Both diets were also associated with improved physical function, and neither had an adverse impact on cardiometabolic outcomes.

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“…However, changes in the abundance of distinct glycan peaks were mostly observed after the weight loss period and the effect of the intense exercise alone could not be inferred (main aim of the study was to assess the effect of energy deprivation leading to substantial fat mass loss). Other relevant studies focused on relation of exercise and GlycA levels, a glycan biomarker of systemic inflammation, where decreasing levels of GlycA following exercise were observed (Bartlett et al, 2017;Barber et al, 2018). However, training interventions investigated in the aforementioned studies were all comprised of either moderate (40-55% VO2max) and/or high-intensity (65-80% VO2max) aerobic exercise (Bartlett et al, 2017;Barber et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Intense Physical Exercise Induces an Anti-inflammatory Change in IgG N-Glycosylation Profile

et al. 2019

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Exercise is known to improve many aspects of human health, including modulation of the immune system and inflammatory status. It is generally understood that exercise reduces inflammation, but there are missing links in terms of understanding the mechanisms as well as the differences between exercise modalities. N-glycosylation of immunoglobulin G (IgG) and total plasma proteins was previously shown to reflect changes in inflammatory pathways, which could provide valuable information to further clarify exercise effects. In order to further expand the understanding of the relationship between physical activity and inflammation, we examined the effect of intense exercise, in the form of repeated sprint training (RST), on IgG and total plasma proteins N-glycosylation in combination with traditionally used inflammation markers: C-reactive protein (CRP), interleukin 6 (IL-6), and leukocyte count. Twenty-nine male physical education students were separated into treatment (RST, N = 15) and control (N = 14) groups. The RST group completed a 6-week exercise protocol while the control group was instructed to refrain from organized physical activity for the duration of the study. Three blood samples were taken at different time points: prior to start of the training program, the final week of the exercise intervention (EXC), and at the end of the 4-week recovery period (REC). Following the end of the recovery period IgG N-glycosylation profiles showed anti-inflammatory changes in RST group compared to the control group, which manifested as a decrease in agalactosylated (p = 0.0473) and an increase in digalactosylated (p = 0.0473), and monosialylated (p = 0.0339) N-glycans. Plasma protein N-glycans didn't change significantly, while traditional inflammatory markers also didn't show significant change in inflammatory status. Observed results demonstrate the potential of intense physical exercise to reduce levels of systemic basal inflammation as well as the potential for IgG N-glycosylation to serve as a sensitive longitudinal systemic inflammation marker.

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Association of the Composite Inflammatory Biomarker GlycA, with Exercise‐Induced Changes in Body Habitus in Men and Women with Prediabetes

Cited by 22 publications

References 79 publications

Title: Human Serum/Plasma Glycoprotein Analysis by 1H-NMR, an Emerging Method of Inflammatory Assessment

Title: Human Serum/Plasma Glycoprotein Analysis by 1H-NMR, an Emerging Method of Inflammatory Assessment

Impact on cardiometabolic risk of a weight loss intervention with higher protein from lean red meat: Combined results of 2 randomized controlled trials in obese middle-aged and older adults

Intense Physical Exercise Induces an Anti-inflammatory Change in IgG N-Glycosylation Profile

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