Association of the C-399T promoter polymorphism of neuropeptide Y with susceptibility to ischemic stroke

Kim, No S.; Oh, Se-Mi; Ko, Mi Mi; Ho, Min; Kang, Byoung Kab; Bang, Ok‐Sun

doi:10.1016/j.clinbiochem.2009.07.012

Cited by 27 publications

(21 citation statements)

References 18 publications

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“…Here, we demonstrate that polymorphism in the NPY promoter at position -399 influences the risk of ischemic stroke in Han Chinese individuals, consistent with previous findings in South Korean and Chinese populations (17,18). Both previous studies found that the C allele confers a higher risk of stroke.…”

Section: Resultssupporting

confidence: 80%

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Neuropeptide Y Gene Promoter -399T/C Polymorphism Increases Risk of Ischemic Stroke

Fu¹,

Zhang²,

Wang³

et al. 2013

Balkan Med J

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Background: Several genetic factors underlying ischemic stroke have been identified. Variants of Neuropeptide Y (NPY), whose product plays diverse roles in modulating physiological functions, have been associated with an increased risk of ischemic stroke in South Korean individuals.Aims: We explored the association between a polymorphism in the NPY gene promoter at position -399 and the risk of ischemic stroke in Han Chinese.Study Design: Case-control study. Methods:The polymorphism -399T/C in the promoter of NPY was analysed in 500 patients with ischemic stroke and 500 healthy individuals by amplification and sequencing of this region. Non-conditional logistic regression was used to analyse association between genotypes and the risk of ischemic stroke.Results: Genotype and allele frequencies differed significantly between the ischemic stroke and control groups (P<0.05). Additionally, compared to stroke patients with the TT genotype, those with the CC genotype had a 1.7-times higher risk of ischemic stroke (OR=1.739, 95%CI=1.201-2.520, P=0.003), especially for those who were over 60 years old or male. Individuals with the TC genotype did not have an increased risk of ischemic stroke (P>0.05). Conclusion:The -399T/C polymorphism of the NPY gene is associated with ischemic stroke in Han Chinese individuals, and the CC genotype may be a risk factor for ischemic stroke.

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Section: Resultssupporting

confidence: 80%

“…However, the NPY promoter region -399T/C polymorphism is associated with the initiation of transcription and can change NPY transcription activity (16); when the -399 locus contains the C nucleotide, plasma NPY levels are higher (12). This polymorphism is also correlated with risk of ischemic stroke in Korean populations (17).…”

Section: Introductionmentioning

confidence: 99%

Neuropeptide Y Gene Promoter -399T/C Polymorphism Increases Risk of Ischemic Stroke

Fu¹,

Zhang²,

Wang³

et al. 2013

Balkan Med J

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“…It was also associated with the risk of ischemic stroke [26] and showed allele-specific effects on NPY gene expression and NPY peptide level [8,23,24,31]. Two of these studies have observed that the rs16147 C allele increases NPY expression [23,31].…”

Section: Discussionmentioning

confidence: 99%

“…The rs16147 single nucleotide polymorphism (SNP) has been shown to have a significant relationship with circulating concentrations of NPY [24,25]. Few previous studies have shown an association between polymorphisms of the NPY gene and an increased risk of cardiovascular disease [24], early-onset atherosclerosis [8], ischemic stroke [26] and effects of a weight loss diet on 2-year changes in blood pressure [27] in different populations.…”

Section: Introductionmentioning

confidence: 99%

Lack of an Association between a Functional Polymorphism in the Neuropeptide Y Gene Promoter and the Presence of Coronary Artery Disease in an Iranian Population

Parizadeh

Jamialahmadi²,

Rooki³

et al. 2014

Ann Nutr Metab

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Background/Aims: Several genetic factors have been identified that may contribute to the risk of coronary artery disease (CAD). Variants of the neuropeptide Y (NPY) gene, whose products play an important role in regulating several physiological functions, have been associated with the risk of CAD in some populations. The purpose of this study was to investigate the relationship between the NPY gene rs16147 polymorphism and the presence of CAD in an Iranian population. Methods: DNA samples of 922 subjects, including 433 with angiographically defined CAD (CAD+), 196 without angiographically defined significant CAD (CAD-) and 293 controls, were genotyped using polymerase chain reaction based on the amplification-refractory mutation system. Logistic regression analyses were performed to assess the association of rs16147 genotypes with the presence of significant CAD. Results: Although logistic regression analysis indicated that the NPY polymorphism rs16147 was nominally associated with an increased risk of CAD (p < 0.05), after adjustment for confounding factors, there was no evidence for any signiﬁcantly increased or decreased risk of CAD with this polymorphism. However, in stratiﬁed analyses, the C allele was signiﬁcantly associated with a reduced risk of CAD in males and subjects who were <50 years of age. Conclusions: This study suggests that the rs16147 polymorphism in the NPY gene may not be a potential contributor to the risk of CAD in an Iranian population.

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“…The NPY gene maps to chromosome 7p15.1 and exists in a single copy [21,22]. One SNP, rs16147 , located in the promoter region of the gene, alters NPY expression and seems to account for nearly half of the variation in expression.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism rs16147 of the Neuropeptide Y Gene Modifies the Response of Cardiovascular Risk Biomarkers and Adipokines to Two Hypocaloric Diets

Luis

Izaola²,

Primo³

et al. 2017

Lifestyle Genomics

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Aims: Our aim was to evaluate the relationship of weight loss and changes in adipokine levels after two hypocaloric diets in obese subjects with polymorphism rs16147 of the neuropeptide Y gene. Subjects and Methods: A population of 283 obese patients was analyzed. At the basal visit, patients were randomly allocated to one of two diets for a period of 3 months (diet I, low in carbohydrates; diet II, low in fat). Results: With diet I and in both genotype groups (major versus minor allele), body mass index (BMI), weight, fat mass, waist circumference, and leptin decreased. With diet II and in all genotypes, BMI, weight, fat mass, waist circumference, and leptin decreased. With both diets and in subjects with the minor allele, insulin levels (diet I: major allele -1.7 ± 7.8 IU/L versus minor allele -4.2 ± 6.1 IU/L, p = 0.01; diet II: major allele -2.3 ± 6.1 IU/L versus minor allele -4.0 ± 5.2 IU/L, p = 0.02) and insulin resistance (diet I: major allele -0.2 ± 3.1 units versus minor allele -1.7 ± 3.0 units, p = 0.03; diet II: major allele -0.9 ± 2.0 units versus minor allele -1.7 ± 1.3 units, p = 0.01) decreased. Conclusion: The rs16147 genotype affected the reduction in insulin resistance and insulin levels in response to two different hypocaloric diets in obese subjects, with a lack of response in subjects with the major allele.

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Association of the C-399T promoter polymorphism of neuropeptide Y with susceptibility to ischemic stroke

Cited by 27 publications

References 18 publications

Neuropeptide Y Gene Promoter -399T/C Polymorphism Increases Risk of Ischemic Stroke

Neuropeptide Y Gene Promoter -399T/C Polymorphism Increases Risk of Ischemic Stroke

Lack of an Association between a Functional Polymorphism in the Neuropeptide Y Gene Promoter and the Presence of Coronary Artery Disease in an Iranian Population

Polymorphism <b><i>rs16147</i></b> of the <b><i>Neuropeptide Y</i></b> Gene Modifies the Response of Cardiovascular Risk Biomarkers and Adipokines to Two Hypocaloric Diets

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