Association of the ApoE gene polymorphism and dietary factors with cerebral infarction and circulating lipid concentrations

Yan, Haiying; Yuan, Yongyi; Zhang, P.; Huang, Zirui; Chang, Li; Gui, Yongkun

doi:10.4238/2015.january.30.9

Cited by 9 publications

(9 citation statements)

References 13 publications

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“…Serum lipid levels are closely correlated with dietary habits, [ 12 ] which in Shandong are quite different from other areas of China. Shandong cuisine is famous for its high salt and soy sauce content, and sodium intakes were high among residents of Shandong province.…”

Section: Introductionmentioning

confidence: 99%

Serum apolipoprotein E concentration and polymorphism influence serum lipid levels in Chinese Shandong Han population

Han

Gao

et al. 2016

Medicine

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Apolipoprotein E (ApoE), which has been shown to influence serum lipid parameters, can bind to multiple types of lipids and plays an important role in the metabolism and homeostasis of lipids and lipoproteins. A previous study showed that ApoE concentration significantly affects serum lipid levels independently of ApoE polymorphism. The serum lipid levels were also closely correlated with dietary habits, and Shandong cuisine is famous for its high salt and oil contents, which widely differ among the different areas in China. Therefore, studying the effect of ApoE polymorphism on ApoE concentration and serum lipid levels in Shandong province is very important.A total of 815 subjects including 285 men and 530 women were randomly selected and studied from Jinan, Shandong province. In order to evaluate the association of ApoE polymorphism and serum level on lipid profiles, the ApoE genotypes, as well as levels of fasting serum ApoE and other lipid parameters, were detected in all subjects.The frequency of the ApoE E3 allele was highest (83.1%), while those of E2 and E4 were 9.4% and 7.5%, respectively, which are similar to those in other Asian populations. ApoE2 allele carriers showed significantly increased ApoE levels but lower levels of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and Apolipoprotein B (ApoB).We found that ApoE level is influenced by ApoE polymorphism in a gene-dependent manner. The ApoE polymorphism showed different influences on serum lipid parameters with increasing age and body mass index (BMI) in our Shandong Han population.

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Section: Introductionmentioning

confidence: 99%

Serum apolipoprotein E concentration and polymorphism influence serum lipid levels in Chinese Shandong Han population

Han

Gao

et al. 2016

Medicine

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“…In a statistical analysis of anthropometric and clinical characteristics between APOE ε4 carriers and non-carriers, only heart rate was significantly higher in APOE ε4 carriers than in non-carriers in both Lao Loum and minorities. Several reports demonstrated that APOE ε4 is associated with AD[ 40 ], cognitive decline[ 21 ], depressive symptoms[ 22 ], stroke[ 23 , 24 ], hypertension[ 25 , 26 ], coronary heart disease[ 24 , 26 ], cardiovascular[ 27 , 28 ], and diabetes[ 29 , 30 ]. Very few studies have addressed the relationship between APOE ε4 and heart rate.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the incidence of AD may be attributable to lifestyle and nutrition [ 4 , 6 , 16 – 20 ]. On the other hand, APOE ε4 is associated not only with AD but also with cognitive decline[ 21 ], depressive symptoms[ 22 ], stroke[ 23 , 24 ], hypertension[ 25 , 26 ], coronary heart disease[ 24 , 26 ], cardiovascular disease[ 27 , 28 ], and diabetes[ 29 , 30 ]. In combination with environmental factors, APOE ε4 may influence the risk of non-communicable diseases.…”

Section: Introductionmentioning

confidence: 99%

APOE Genotype in the Ethnic Majority and Minority Groups of Laos and the Implications for Non-Communicable Diseases

et al. 2016

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BackgroundIncreasing age is associated with elevated risk of non-communicable diseases, including dementia and Alzheimer’s disease (AD). The apolipoprotein E (APOE) ε4 allele is a risk factor not only for AD, but also for cognitive decline, depressive symptoms, stroke, hypertension, coronary heart disease, cardiovascular disease, and diabetes. The Lao People’s Democratic Republic (Laos) is undergoing development; consequently, life expectancy has risen. To evaluate the future risk of non-communicable diseases, we investigated APOE genotypes and anthropometric characteristics in the Laotian population.Methodology/Principal FindingsSubjects were 455 members of the Lao Loum majority and 354 members of ethnic minorities. APOE genotypes, anthropometric characteristics, blood pressure, and blood glucose were recorded. To compare individual changes, health examination data collected 5 years apart were obtained from a subset of Lao Loum subjects. APOE ε4 allele frequencies were higher among minorities (31.3%) than among Lao Loum (12.6%). In Lao Loum, but not in minorities, mean waist circumference and blood pressure increased significantly across age groups. Comparisons of health conditions between the beginning and end of the 5-year period revealed significant increases in obesity and blood glucose levels in Lao Loum. APOE ε4 carriers exhibited significant increases in resting heart rate in both ethnic groups.Conclusions/SignificanceA higher ε4 allele frequency was observed in Laotian minorities than in the Laotian majority. Furthermore, higher obesity, blood pressure and blood glucose were observed in the middle-aged ethnic majority. Therefore, given these genetic and non-communicable disease risk factors, it seems likely that as the Laotian population ages, elevated rates of non-communicable aging-related diseases, such as dementia, will also become more prevalent.

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“…Genetic factors and poor habits are two main causes of cerebral infarction (26). According to an epidemiological study, hyperlipidemia and hypertension are two important factors that greatly increase the risk of cerebral infarction (2).…”

Section: Original Investigationmentioning

confidence: 99%

Mir-24 reduces serum lipid levels and inhibits brain tissue cells apoptosis of rats with cerebral infarction

Jiang

Shen²,

Wang³

et al. 2018

Turkish Neurosurgery

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AIM: To study miR-24 effects on cerebral infarction in rats. MATERIAL and METHODS: A rat middle cerebral artery occlusion model (MCAO) was constructed. Intracerebroventricular stereotactic injection of miR-24 agomir/antagomir was performed in the rat MCAO model. According to different experiences, rats were divided into normal, sham, MCAO, miR-24 agomir and miR-24 antagomir groups. Serum TCH, HDL and TG levels were detected. RESULTS: Comparingthe normal and sham groups, we observed decreased relative miR-24 expression (P< 0.05) and increased cerebral infarction area percentage, apoptotic cells and relative caspase-3 protein expression (P< 0.05) in theMCAO, miR-24 agomirand miR-24 antagomir groups. TC, TG and HDL-C levels of the MCAO and miR-24 antagomir groups were higher than those of normal and sham groups (P< 0.05).Compared with the MCAO group, increased relative miR-24 expression (P< 0.05) and decreased TC, TG and HDL-C levels,cerebral infarction area percentage, number of apoptotic cells and caspase-3 expression (P< 0.05) were found in themiR-24 agomir group, contrasting with theobservations from the miR-24 antagomir group. CONCLUSION: miR-24 reduced serum TCH, HDL and TG levels and inhibited brain tissue cell apoptosis in rats with cerebral infarction.

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Association of the ApoE gene polymorphism and dietary factors with cerebral infarction and circulating lipid concentrations

Cited by 9 publications

References 13 publications

Serum apolipoprotein E concentration and polymorphism influence serum lipid levels in Chinese Shandong Han population

Serum apolipoprotein E concentration and polymorphism influence serum lipid levels in Chinese Shandong Han population

APOE Genotype in the Ethnic Majority and Minority Groups of Laos and the Implications for Non-Communicable Diseases

Mir-24 reduces serum lipid levels and inhibits brain tissue cells apoptosis of rats with cerebral infarction

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