Association of the Alu insertion polymorphism in the progesterone receptor gene with breast cancer in a Mexican population

Gallegos‐Arreola, Martha Patricia; Figuera, Luis E.; Gómez-Flores-Ramos, Liliana; Puebla-Pérez, Ana Marı́a; Zúñiga‐González, Guillermo Moisés

doi:10.5114/aoms.2015.52357

Cited by 26 publications

(38 citation statements)

References 36 publications

(84 reference statements)

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“…In this sense, it is important to perform epidemiological studies that include risk factors to determine possible causes of this complicated disease in different populations. In Mexico, CRC is considered to be a major health issue, as its incidence has increased over the last 20 years, and it is currently one of the leading causes of death for both women and men (Gallegos-Arreola et al, 2009;Alberts et al, 2014;Binefa et al, 2014;Siegel et al, 2014). These facts are consistent with the observations made in our current study, in which the average patient age was 59.51 ± 12.12 years.…”

Section: Discussionsupporting

confidence: 83%

“…Nine percent of the patients studied had a familial history of cancer (7% of which reported a family history of grade I CRC; data not shown). This frequency is consistent with the overall rates reported in the literature concerning cancer in individuals with or without family history of CRC (Gallegos-Arreola et al, 2009;Henrikson et al, 2015). The body mass index (BMI) of most patients in this study was categorized as normal or underweight.…”

Section: Discussionsupporting

confidence: 80%

“…New techniques and approaches that permit better detection of CRC are now being used in developing countries with a high incidence of this disease (Chen and Sheen-Chen, 2000;Gallegos-Arreola et al, 2009). Nine percent of the patients studied had a familial history of cancer (7% of which reported a family history of grade I CRC; data not shown).…”

Section: Discussionmentioning

confidence: 99%

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Association between TNF-α-308G>A and -238G>A gene polymorphisms and TNF-α serum levels in Mexican colorectal cancer patients

et al. 2016

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ABSTRACT. The objective of this study was to examine the association between TNF-α serum levels and -308G>A and -238G>A polymorphisms in the corresponding gene by comparing healthy subjects to colorectal cancer (CRC) patients from a Mexican population. Serum levels of TNF-α were found to significantly differ between CRC patients and controls (P = 0.001), but no relationship between the -308G>A and -238G>A polymorphisms and increased CRC risk was established (P > 0.05). However, an association between the -308G>A variant and disease became evident when the distribution of AA-GA genotypes was examined in patients with hematologic toxicity (neutropenia) and those without (odds ratio = 3.356, 95% confidence interval = 1.295-8.698, P = 0.013). The GG haplotype was more common in controls than CRC patients, with a frequency of 0.85 among the former, but this difference was not significant (P > 0.05). In conclusion, TNF-α serum levels and AA-AG genotypes of the TNF-α -308G>A polymorphism may significantly contribute to CRC susceptibility in the population examined in this investigation.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

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Association between TNF-α-308G>A and -238G>A gene polymorphisms and TNF-α serum levels in Mexican colorectal cancer patients

et al. 2016

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“…In conclusion, hypothesis concerning ERα and PR oversensitivity in women with gigantomastia should be verified by looking for specific gene polymorphisms that could cause this condition. Moreover, analysing abnormal sensitivity of receptors to hormones may also be crucial in establishing the increased risk of breast cancer in women with gigantomastia, because receptor polymorphisms causing receptor hypersensitivity related to increased breast cancer risk were detected [29][30][31].…”

Section: Discussionmentioning

confidence: 99%

The role of oestrogen and progesterone receptors in gigantomastia

Kasielska‐Trojan¹,

Danilewicz

Strużyna³

et al. 2019

Arch Med Sci

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Introduction: Gigantomastia is a rare condition characterised by excessive breast growth. The pathophysiology of mammary enlargement varies depending on the type of gigantomastia: gestational, juvenile virginal, or idiopathic. The study aimed at examining the receptor status (oestrogen receptor alpha [ERα] and progesterone receptor [PR]) of breast tissue in adult women with juvenile or idiopathic gigantomastia. Material and methods: The study involved 70 women who underwent breast reduction due to juvenile or idiopathic gigantomastia. Control breast specimens were obtained from 18 female cadavers. ERα and PR expressions were detected immunohistochemically in breast gland samples. Results: Categorised and uncategorised ERα and PR expression did not differ between women with gigantomastia and control women. It was found that in both groups weak (0-30%) ERα and PR expression was the most common. Analysis of categorised data also did not reveal any significant correlations between ERα or PR and the women's age: for the whole group: p = 0.795 (ERα), p = 0.207 (PR), for women with gigantomastia: p = 0.934 (ERα), p = 0.43 (PR), and for control women: p = 0.638 (ERα), p = 0.805 (PR). Conclusions: Gigantomastia is not caused by increased expression of ERα and PR. Analysing abnormal sensitivity of these receptors to hormones may be crucial in establishing the increased risk of breast cancer in women with gigantomastia.

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“…In a Chinese cohort, the Alu insertion and Val660Leu polymorphisms were associated with a risk of ovarian cancer, whereas the 331G/A SNP could not be correlated with any cancer risk [213]. In a Caucasian cohort of endometrial cancer patients, the 331G/A SNP could not be correlated with a cancer risk [279], but, in another study, the Alu insertion variant was associated with a higher breast cancer incidence in Mexican women [113]. …”

Section: Disparities At the Nuclear Genome Level And Their Role Inmentioning

confidence: 99%

Mitochondrial determinants of cancer health disparities

Choudhury

Singh

2017

Seminars in Cancer Biology

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Mitochondria are involved in the generation of energy, cell growth and differentiation, cellular signaling, cell cycle control, and cell death. To date, the mitochondrial basis of cancer disparities is unknown. The goal of this review is to provide an understanding and a framework of mitochondrial determinants that may contribute to cancer disparities in racially different populations. Mitochondria, which are multi-functional, have been implicated in the initiation and progression of cancers in relation to metabolic alterations in transformed cells. Due to ethnic-based diversity, the mitochondrial genome (mtDNA) could be a basis for inherited racial disparities and for acquired somatic mutations during tumorigenesis. In African Americans, several germline, population-specific haplotype variants in mtDNA as well as depletion of mtDNA have been linked to cancer predisposition and cancer disparities. Indeed, depletion of mtDNA and mutations in mtDNA or nuclear genome (nDNA)-encoded mitochondrial proteins lead to mitochondrial dysfunction and promote resistance to apoptosis, the epithelial-to-mesenchymal transition, and metastatic disease, which in turn can contribute to cancer disparity and tumor aggressiveness related to racial disparities. Ethnic differences at the level of expression or genetic variations in nDNA encoding the mitochondrial proteome, including mitochondria-localized mtDNA replication and repair proteins, miRNA, transcription factors, kinases and phosphatases, and tumor suppressors and oncogenes may underlie susceptibility to high-risk and aggressive cancers found in African Americans and other ethnicities. The mitochondrial retrograde signaling that alters the expression profile of nuclear genes in response to dysfunctional mitochondria is a mechanism for tumorigenesis. In ethnic populations, differences in mitochondrial function may alter the cross talk between mitochondria and the nucleus at epigenetic and genetic levels, which can also contribute to cancer health disparities. Targeting mitochondrial determinants and mitochondrial retrograde signaling could provide a promising strategy for the development of selective anticancer therapy for dealing with cancer disparities. Further, agents that restore mitochondrial function to optimal levels should permit sensitivity to anticancer agents for the treatment of aggressive tumors that occur in racially diverse populations and hence help in reducing racial disparities.

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Association of the Alu insertion polymorphism in the progesterone receptor gene with breast cancer in a Mexican population

Cited by 26 publications

References 36 publications

Association between TNF-α-308G>A and -238G>A gene polymorphisms and TNF-α serum levels in Mexican colorectal cancer patients

Association between TNF-α-308G>A and -238G>A gene polymorphisms and TNF-α serum levels in Mexican colorectal cancer patients

The role of oestrogen and progesterone receptors in gigantomastia

Mitochondrial determinants of cancer health disparities

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