Association of the −344C/T aldosterone synthase (CYP11B2) gene variant with hypertension and stroke

Association of LPL gene variant and LDL, HDL, VLDL cholesterol and triglyceride levels with ischemic stroke and its subtypes

“…Stroke is a multifactorial disorder influenced by genetic and environmental factors [1][2][3][4][5][6][7][8]. Evidence suggests that variations in the lipoprotein lipase gene may influence stroke risk [9].…”

Association of AGT M235T and ACE I/D polymorphisms with the risk of ischemic stroke: Meta-analysis in Han Chinese population

“…Furthermore, RAAS is involved in vascular remodeling, generation of oxidative stress, and inflammation in the atherosclerotic process [8,9], and RAAS polymorphisms have shown a possible association with the ischemic stroke. Several polymorphisms within the RAAS genes, such as the gene encoding aldosterone synthase (CYP11B2), angiotensin II type 1 receptor (AT1R), angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) have been reported to be significantly associated with hypertension and ischemic stroke [10][11][12][13]. Among these polymorphisms, the AGT-M235T and ACE I/D polymorphisms are the most prominent and universal-investigated variants.…”

Association of CYP11B2 gene polymorphism with ischemic stroke in the north Chinese Han population

“…The -344C/T polymorphism has previously been described to be related to the risk of stroke. [14,21] However, findings from Sardinians failed to find the association. [15] Recently, -344C/T has been found associated with IS in a Southern Chinese population.…”

“…[11] To date, association studies of the -344C/T polymorphism with stroke and hypertension have yielded conflicting results. [12][13][14][15] Fewer investigations have examined the association between the intron 2 conversion polymorphism and essential hypertension, and contrasting results have also been reported. [16,17] To our knowledge, no report has so far been published examining the intron 2 conversion and its association with stroke.…”