Association of Target Organ Damage With Three Arterial Stiffness Indexes According to Blood Pressure Dipping Status in Untreated Hypertensive Patients

Abstract

The simultaneous estimation of three noninvasive indexes of arterial stiffness leads to valuable information regarding their association with TOD including CFR, MAU levels, IMT, left ventricular diastolic dysfunction, and LA enlargement in never-treated hypertensive patients regarding their dipping status.

Pulsatile Hemodynamics and Clinical Outcomes in Acute Heart Failure

“…34,35 Elevated arterial stiffness may precipitate AHFS through acute elevation of SBP that exacerbates diastolic function. 34,[36][37][38] Our results supported this hypothesis by showing the progressive parallel reduction of brachial and central SBP and PP, and cf-PWV during the hospital course and the early discharge period in patients without events. In 72 stable heart failure patients with an averaged LV ejection fraction of 53%, elevated arterial stiffness evaluated by brachial-ankle PWV was a risk factor for rehospitalization or mortality.…”

Association of Changes in Ambulatory Arterial Stiffness Index and Pulse Wave Velocity During Antihypertensive Treatment: The J-CORE Study

“…1 Recently, the ambulatory arterial stiffness index (AASI), defined as 1 minus the respective regression slope of diastolic blood pressure (DBP) on systolic blood pressure (SBP) during 24-h ambulatory BP monitoring (ABPM), has been recognized as a surrogate measure of arterial stiffness, as is cfPWV. 2 In hypertensive subjects, however, the correlation between AASI and cfPWV has been reported to be poorer [3][4][5][6] than that of healthy individuals, 1 and any such correlation was shown to be lost after adjustments were made for potential confounding factors. [3][4][5] Furthermore, several investigators have raised doubts as to whether AASI is a specific marker of arterial stiffness, based on evidence demonstrating that AASI is strongly influenced by the degree of nocturnal BP fall.…”

“…[3][4][5] Furthermore, several investigators have raised doubts as to whether AASI is a specific marker of arterial stiffness, based on evidence demonstrating that AASI is strongly influenced by the degree of nocturnal BP fall. [3][4][5][6][7] In order to resolve the drawbacks of the AASI, the symmetrical AASI, 8 which is not dependent on nocturnal BP characteristics, has been used as an alternative.…”

Arterial rigidity and cerebrovascular disorders

“…Показано, что по-вышенная АР является общим патофизиологическим меха-низмом сочетанного поражения сердца и мозга, причем зна-чение этого фактора не зависит от возраста и длительности АГ [30]. Повышение индексов АР также ассоциировалось со снижением коронарного резерва, микроальбуминурией, толщиной комплекса интима-медиа, диастолической дис-функцией ЛЖ и расширением левого предсердия [31].…”