Association of T CD4 lymphocyte levels and subgingival microbiota of chronic periodontitis in HIV-infected Brazilians under HAART

Gonçalves, Lúcio Souza; Ferreira, Sônia Maria Soares; Silva, Arley; Villoria, German Eduardo Miguel; Costinha, Lúcia Helena; Souto, Renata; Uzeda, Milton de; Colombo, Ana Paula Vieira

doi:10.1016/j.tripleo.2003.08.023

Cited by 33 publications

(49 citation statements)

References 35 publications

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“…It seems that oriented self care is the key point in the maintenance of oral hygiene in HIV infected subjects. These results are in agreement with those of other authors, who have achieved success after mechanical therapy in HIV infected patients (2,7,11,12 In this study, the supportive periodontal therapy and the patient's cooperation in maintenance of oral hygiene improved the periodontal aspect in both HIV-seropositive and AIDS patients. There are some limitations which must be considered before the conclusions are drawn because this study was conducted in a closed population, represents a small sample and the non inclusion of a control group due to ethnical concepts by asking for HIV tests.…”

Section: Discussionsupporting

confidence: 93%

“…These results suggest that immunodeficiency alone does not predispose patients to gingival and periodontal disease, since patients underwent an oral hygiene protocol. Other authors have also reported no consistent effect between periodontal status, HIV infection and CD4 count (3,4,7,11,20). A clear reduction in the gingival parameters and the improvement in the gingival condition in different HIV staging groups were evident after mechanical therapy.…”

Section: Discussionmentioning

confidence: 97%

“…Studies have associated a severe attachment loss or increased periodontal attachment loss in individuals with more advanced stages of AIDS (6). However, an association between periodontal disease and immune status in the HIV-infected individual is not yet clear (7). Bacterial plaque is generally considered to be the main etiological agent in gingival and periodontal disease (8).…”

Section: Introductionmentioning

confidence: 99%

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Periodontal disease and oral hygiene benefits in HIV seropositive and AIDS patients

Lemos

Oliveira²,

Vêncio³

2010

Med Oral

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Periodontal disease and oral hygiene benefits in HIV seropositive and AIDS patients

Lemos

Oliveira²,

Vêncio³

2010

Med Oral

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“…It has been suggested that the loss of CD4+ T-lymphocytes and subsequent immunosuppression in HIV-infected individuals could compromise normal mucosal responses to oral microorganisms, resulting in an elevated colonization of cariogenic and periodontal pathogens or an alteration of the oral microbial community (Patel et al, 2003;Gonçalves et al, 2004Gonçalves et al, , 2007Aas et al, 2007;Saxena et al, 2012). Those changes could be contributing factors for the development of HIV-associated oral diseases, including increased prevalence of dental caries.…”

Section: Discussionmentioning

confidence: 99%

HIV Infection Affects Streptococcus mutans Levels, but Not Genotypes

et al. 2012

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We report a clinical study that examines whether HIV infection affects Streptococcus mutans colonization in the oral cavity. Whole stimulated saliva samples were collected from 46 HIV-seropositive individuals and 69 HIV-seronegative control individuals. The level of S. mutans colonization was determined by conventional culture methods. The genotype of S. mutans was compared between 10 HIV-positive individuals before and after highly active antiretroviral therapy (HAART) and 10 non-HIV-infected control individuals. The results were analyzed against viral load, CD4+ and CD8+ T-cell counts, salivary flow rate, and caries status. We observed that S. mutans levels were higher in HIV-infected individuals than in the non-HIV-infected control individuals (p = 0.013). No significant differences in S. mutans genotypes were found between the two groups over the six-month study period, even after HAART. There was a bivariate linear relationship between S. mutans levels and CD8+ counts ( r = 0.412; p = 0.007), but not between S. mutans levels and either CD4+ counts or viral load. Furthermore, compared with non-HIV-infected control individuals, HIV-infected individuals experienced lower salivary secretion (p = 0.009) and a positive trend toward more decayed tooth surfaces (p = 0.027). These findings suggest that HIV infection can have a significant effect on the level of S. mutans, but not genotypes.

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“…HIV-associated NUG and NUP were initially considered specific disease conditions. Microbiology there is no major difference between HIV-positive and HIV negative subjects 17,18,19 . A study was done to examine by Transmission Electron Microscope and Scanning Electron Microscope the supragingival microbial plaque overlying the ulcerated gingival papillae of NUP lesions in HIV-seropositive patients.…”

Section: Necrotizing Ulcerative Gingivitis (Nug) and Necrotizing Ulcementioning

confidence: 97%

Oral Cavity: A Mirror to Hiv Manifestations

Grover¹,

Bhardwaj²,

Gupta³

2013

Int. Res. J. Pharm.

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A multitude of oral lesions have been described in individuals infected with the human immunodeficiency virus. Human immunodeficiency virus infection is a major interest and concern to dentists and other health care workers because of the many varieties of oral lesions often associated with Human immunodeficiency virus infection. Individual's tested seropositive for Human immunodeficiency virus infections are more susceptible to occurrence of lesions in oral cavity. This review covers the clinical and therapeutics aspects of Human immunodeficiency virus associated oral diseases. Data was collected from detailed search through research and review articles of scientific journals and magazines as well as through Pubmed and National medical library database.

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Association of T CD4 lymphocyte levels and subgingival microbiota of chronic periodontitis in HIV-infected Brazilians under HAART

Cited by 33 publications

References 35 publications

Periodontal disease and oral hygiene benefits in HIV seropositive and AIDS patients

Periodontal disease and oral hygiene benefits in HIV seropositive and AIDS patients

HIV Infection Affects Streptococcus mutans Levels, but Not Genotypes

Oral Cavity: A Mirror to Hiv Manifestations

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