Association of Systemic Inflammation and Malnutrition With Survival in Nasopharyngeal Carcinoma Undergoing Chemoradiotherapy: Results From a Multicenter Cohort Study

Wang, Xin; Yang, Ming; Ge, Yi‐Zhong; Tang, Meng; Rao, Benqiang; Chen, Yongbing; Xu, Hongxia; Ma, Cong; Guo, Zengqing; Shi, Hanping

doi:10.3389/fonc.2021.766398

Cited by 17 publications

(18 citation statements)

References 33 publications

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“…For many years, the link between in ammation and cancer has attracted widespread attention, and in ammation plays a crucial role in the development of malignancy. Systemic in ammation is common in patients with NPC and the risk of death is increased 4.5-fold in patients with systemic in ammation with malnutrition (20). Rapid proliferation and in ammatory cell in ltration is an important feature of patients with NPC (4,21).…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Targeting the PLUNC-NLRP3 inflammasome axis could inhibit nasopharyngeal carcinoma lung metastasis

Zhou

Qiu

Liu

et al. 2023

Preprint

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Nasopharyngeal carcinoma (NPC) is a malignant tumor that occurs in the nasopharynx. PLUNC is an early identified secreted protein specifically expressed in the nasopharynx that acts a potential suppresser gene in NPC, but its specific biological role and its mechanism are unclear. We used mRNA-seq combined with RNC-seq to identify the biological role of PLUNC. Tail vein injection of NPC cells to observe the biological role of PLUNC in vivo. The activation of NLRP3 inflammasome was detected by immunoblotting assays and immunofluorescence, and the expression of EMT-related molecules was detected by immunoblotting assays. Then, the migration and invasion were detected by wound healing assay and transwell chamber assay. The mRNA-seq and RNC-seq results showed that PLUNC inhibited NPC progression, and data analysis revealed its correlation with NOD-like receptors. The results confirmed that PLUNC was negatively correlated with NLRP3 inflammasome, and in vivo experiments further elucidated that PLUNC inhibited NPC lung metastasis, and that PLUNC overexpression combined with MCC950 could most effectively inhibit NPC lung metastasis. Our results suggest that PLUNC could inhibit lung metastasis of NPC by suppressing the activation of NLRP3 inflammasome, and targeting the PLUNC-NLRP3 inflammasome axis may provide a new therapeutic strategy for NPC patients.

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Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Targeting the PLUNC-NLRP3 inflammasome axis could inhibit nasopharyngeal carcinoma lung metastasis

Zhou

Qiu

Liu

et al. 2023

Preprint

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“…Malnutrition is a common manifestation in patients with lung cancer (3,23). Malnutrition works in conjunction with inflammation and the immune status to affect the health level of the body, leading to a poor prognosis (24,25). It is one of the main factors associated with mortality.…”

Section: Discussionmentioning

confidence: 99%

Sex differences in the association of phase angle and lung cancer mortality

et al. 2022

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BackgroundLung cancer is a lethal malignant tumor that is common worldwide and is associated with a high incidence of malnutrition. Phase angle (PA) is a simple, objective, and non-invasive indicator of body composition that has increasingly attracted attention as an indicator of the nutritional status and prognosis of patients with malignant tumors. This study aimed to investigate the association between the PA and overall survival in patients with lung cancer.MethodsThis study prospectively analyzed 804 lung cancer patients in the Investigation on Nutrition Status and its Clinical Outcome of Common Cancers (INSCOC) project from 40 hospitals in China. We used a restricted cubic spline to analyze the sex-specific association between PA and mortality in men and women with lung cancer. Cox regression analysis was used to evaluate the independent association between PA and mortality in men and women. Sensitivity analysis was performed. The Kaplan–Meier method was used to evaluate the survival of patients with high and low PA values.ResultsThere was an L-shaped association between PA and survival in both men and women with lung cancer (p = 0.019 and p = 0.121, respectively). Kaplan–Meier survival analysis suggested that patients with a high PA showed a better survival than patients with a low PA (p = 0.007 for men and p < 0.001 for women). Multivariate-adjusted Cox regression analysis showed that PA was an independent risk factor for mortality in men (HR = 0.79, 95% CI = 0.65–0.95, p = 0.015), but not in women (HR = 0.83, 95% CI = 0.67–1.04, p = 0.105).ConclusionPhase angle is an independent risk factor for the mortality of male lung cancer patients. However, its role in predicting the mortality of female lung cancer patients seems to be limited.

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“…However, this study was not tailored to cancer patients primarily. Wang et al showed a clear association between high inflammation, clinical malnutrition and overall survival in patients with nasopharyngeal carcinoma [16]. These studies show that inflammation could be a key factor in cancer-related malnutrition.…”

Section: Inflammation and Malnutritionmentioning

confidence: 91%

“…Recent studies have shown that inflammatory models can be used to predict prognosis, as well as cancer-related malnutrition [15]. High level of systemic inflammatory factors which can facilitate tumour cell proliferation and metastasis are also known to be induced by malnutrition [16]. Thus, malnutrition can enhance a systemic inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

Inflammation-Based Markers of Nutrition in Cancer Patients

Izuegbuna¹

2023

Combating Malnutrition Through Sustainable Approaches

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Malnutrition and cachexia are common findings in cancer patients, and they predict poorer clinical outcomes. Close to half of cancer patients regardless of cancer type have malnutrition and will require one form of nutritional support either before or during treatment. The early identification of malnutrition is thus important to physicians and caregivers. The role of inflammation in the development and progression of malnutrition and cachexia is being unravelled. Increasing evidence shows that systemic inflammatory response and nutritional status are involved in tumour development and influence the clinical prognosis. Serum proteins such as albumin and prealbumin have traditionally been used by physicians to determine patient nutritional status. More recently, inflammation-based prognostic scores including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), C reactive protein-to-albumin ratio (CAR), prognostic nutritional index (PNI), Glasgow Prognostic Score (GPS) have shown promise and have begun to be used in clinical practice to predict prognosis of cancer patients. This chapter highlights the role and pathophysiology of inflammation-based markers in assessing malnutrition and cachexia and their relationship to clinical screening tools.

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Association of Systemic Inflammation and Malnutrition With Survival in Nasopharyngeal Carcinoma Undergoing Chemoradiotherapy: Results From a Multicenter Cohort Study

Cited by 17 publications

References 33 publications

WITHDRAWN: Targeting the PLUNC-NLRP3 inflammasome axis could inhibit nasopharyngeal carcinoma lung metastasis

WITHDRAWN: Targeting the PLUNC-NLRP3 inflammasome axis could inhibit nasopharyngeal carcinoma lung metastasis

Sex differences in the association of phase angle and lung cancer mortality

Inflammation-Based Markers of Nutrition in Cancer Patients

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