Association of Sudden Sensorineural Hearing Loss With Vertebrobasilar Insufficiency

Hsu, Yin Hsuan; Hu, Hsiao Yun; Chiu, Yu Chwen; Lee, Fei Peng; Huang, Hung Meng

doi:10.1001/jamaoto.2016.0845

Cited by 18 publications

(21 citation statements)

References 29 publications

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“…Specifically, some manuscripts report a significant association between hypertension, renal disease, hyperlipidemia, diabetes and ISSNHL. (3,4,6) However, other papers from the same database did not reproduce one more of these significant associations. (4,12,18) Reasons for inconsistencies in database studies are myriad, but can include heterogeneous data preparation, coding, sampling and/or statistical methodologies.…”

Section: Discussionmentioning

confidence: 98%

“…Indeed, evidence exists for associations between ISSNHL with primary cardiovascular disease and risk factors such as hypertension, hyperlipidemia, smoking, renal disease, and iron deficiency anemia. (2–4,6–9,12) Other investigators have linked high GP-IIIa platelet concentration, fibrinogen concentration, and genetic mutations (i.e. phosphodiesterase 4D gene polymorphisms) that predispose to thromboembolic events as risk factors for ISSNHL.…”

Section: Discussionmentioning

confidence: 99%

“…A significant portion of the population-level work that explored links between ISSNHL and cardiovascular disease are sourced from one Taiwanese administrative dataset - the ‘LHID2000’ claims database - from the Taiwan National Health Insurance Program. (3,4,6,12,16–19) This database contains health care claim data from a period of 1996–2010. Despite being sourced from the same population, significant inconsistencies in associations between cardiovascular risk factors have been published.…”

Section: Discussionmentioning

confidence: 99%

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Idiopathic Sudden Sensorineural Hearing Loss Is Not a Sentinel Event for Acute Myocardial Infarction

Crowson¹,

Mulder

Cyr

et al. 2018

Otology &Amp; Neurotology

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Idiopathic Sudden Sensorineural Hearing Loss Is Not a Sentinel Event for Acute Myocardial Infarction

Crowson¹,

Mulder

Cyr

et al. 2018

Otology &Amp; Neurotology

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“…However, the etiology and pathogenesis of SSNHL are still unclear. Current studies suggest that viral infections [2], autoimmune diseases [3], inflammatory lesions, tumors [5], trauma [6] and vascular diseases [7] are associated with SSNHL. In addition, the currently more recognized possible pathogenesis of SSNHL focuses on the inner ear vascular spasm, vascular striatum dysfunction, vascular embolism or thrombosis, hydrocephalus membranous labyrinth and hair cell damage.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the currently more recognized possible pathogenesis of SSNHL focuses on the inner ear vascular spasm, vascular striatum dysfunction, vascular embolism or thrombosis, hydrocephalus membranous labyrinth and hair cell damage. Among them, more and more evidence points to a tight relationship between dyslipidemia and SSNHL [7].…”

Section: Introductionmentioning

confidence: 99%

Association of Dyslipidemia With Sudden Sensorineural Hearing Loss: A Retrospective Study

Li¹,

Xu²,

Yang³

et al. 2020

Preprint

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Background: Blood lipid levels have been widely studied in patients with sudden sensorineural hearing loss (SSNHL), but it has been unclear whether dyslipidemia associates with SSNHL. Whether there is a simple and feasible blood lipid index to predict the onset of SSNHL remains to be found.Methods: This study reviewed 100 SSNHL patients and 100 healthy subjects who received relevant clinical examination in our hospital from June 1, 2015 to June 1, 2019. The demographic, clinical characteristics, lipid levels and lipid metabolism indexes of the two groups were compared.Results: In this study, 100 patients (64 men [64%]; 36 women [36%]; mean [SD] age, 38.47 [14.36] years) were included in the SSNHL group, and 100 healthy people(60 men [60%]; 40 women [40%]; mean [SD] age, 36.52 [9.86] years) served as the control group. No significant differences between the SSNHL group and the control group in age, sex, BMI, smoking habits and alcohol drinking patterns were observed. Meanwhile, it can be seen the mean (SD) concentrations of total cholesterol (TC) (194.59 [38.22] vs 176.83 [23.55] mg/dL; MD, 17.76 mg/dL; 95% CI, 26.64-46.72 mg/dL), the mean (SD) concentrations of low density lipoprotein cholesterol (LDL-C) (116.99 [33.59] vs 96.91 [22.01] mg/dL; MD, 20.08 mg/dL; 95% CI, 32.43-48.26 mg/dL) and apolipoprotein (apo) B (89.82 [21.38] vs 81.16 [16.17] mg/dL; MD, 8.66 mg/dL; 95% CI, 12.03-23.21 mg/dL) were significantly higher than the control group. In addition, it was also observed that the median [IQR] concentrations of high density lipoprotein cholesterol (HDL-C) (1.51 [1.33-1.76] vs 1.56 [1.40-1.84] mg/dL) and the median [IQR] concentrations of apolipoprotein (apo) AI (118.50 [103.00-141.25] vs 133.00 [115.25-1.52.75] mg/dL) were lower than those in the control group. In terms of lipid metabolism indexes, the median [IQR] value of TC/HDL-C (3.31 [2.68-3.85] vs 2.72 [2.42-3.37]), the mean (SD) value of apo B/apo AI (0.76 [0.26] vs 0.63 [0.18]; MD, 0.13; 95% CI, 0.20-0.32) and the median [IQR] value of atherogenic index (ATH index) (1.61 [0.97-2.50] vs 1.01 [0.73-1.75]) were significantly higher than the control group, while the mean (SD) value of atherogenic index of plasma (AIP) (-0.24 [0.28] vs -0.25 [0.21]; MD, 0.01; 95% CI, -0.06-0.08) showed no difference between the two groups.Conclusions: There were significant differences in blood lipid levels and lipid metabolism between the SSNHL group and the control group. LDL-C, apo AI and apo B were important independent predictors of SSNHL.

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Association Between Middle Ear Cholesteatoma and Chronic Rhinosinusitis

Kuo

Yen

Chang

et al. 2017

JAMA Otolaryngol Head Neck Surg

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IMPORTANCE Chronic rhinosinusitis (CRS) can cause an obstruction of the tubal orifice and thereby compromise ventilation of the middle ear. The resulting negative pressure in the middle ear may, in turn, lead to the formation of an eardrum retraction pocket and subsequent acquired cholesteatoma. This study hypothesizes that CRS may increase the risk of cholesteatoma. OBJECTIVE To evaluate the risk of cholesteatoma in patients with CRS. DESIGN, SETTING, AND PARTICIPANTS This study used a nationwide, population-based claims database to test the hypothesis that CRS may increase the risk of cholesteatoma. The Longitudinal Health Insurance Database of Taiwan was used to compile data from (1) 12 670 patients with newly diagnosed CRS between January 1, 1997, and December 31, 2002, and (2) a comparison cohort of 63 350 matched individuals without CRS, resulting in a CRS vs control ratio of 1:5. Data analysis was performed from June 1 to October 27, 2015. Each patient was followed up for 8 years to identify those in whom cholesteatoma subsequently developed. The Kaplan-Meier method was used to determine the cholesteatoma-free survival rate, and the log-rank test was used to compare survival curves. Cox proportional hazards regression models were used to compute the 8-year hazard ratios (HRs). MAIN OUTCOMES AND MEASURES Diagnosis of cholesteatoma. RESULTS Among the 76 020 patients enrolled in this study, 35 220 (46.3%) were female; mean (SD) age was 27.57 (22.03) years. A total of 209 patients developed cholesteatoma, 66 (101 084 person-years) individuals from the CRS cohort and 143 (506 540 person-years) from the comparison cohort were diagnosed with cholesteatoma during the 8-year follow-up period. The incidence of cholesteatoma per 1000 person-years was more than twice as high among patients with CRS (0.65; 95% CI, 0.50-0.81 person-years) than among those without CRS (0.28; 95% CI, 0.24-0.33). The absolute difference in the incidence density between CRS and non-CRS group was 0.37 (95% CI, 0.21-0.53) per 1000 patient-years. After adjusting for potential confounders, patients with CRS had a 69% increased risk of cholesteatoma within 8 years, compared with those without CRS (HR, 1.69; 95% CI, 1.23-2.32). Patients with CRS presented a significantly lower 8-year cholesteatoma-free survival rate than did those in the comparison group. The absolute difference in the 8-year cholesteatoma-free survival rate between the CRS and non-CRS groups was 0.0029 (95% CI, 0.0016-0.0043). CONCLUSIONS AND RELEVANCE This is the first large-scale study, to date, to demonstrate a prospective link between CRS and the subsequent development of cholesteatoma within a follow-up period of 8 years. The purpose of the study was to draw attention to the possibility of development of cholesteatoma among patients with CRS. Because that possibility exists, clinicians should keep this association in mind as well as the importance of a thorough head and neck examination.

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Association of Sudden Sensorineural Hearing Loss With Vertebrobasilar Insufficiency

Abstract: Patients with VBI appear to be at increased risk of developing SSNHL. Further research is needed to investigate the association among the severity of VBI, the risk of SSNHL, and the pattern of the audiometric curve.

Cited by 18 publications

References 29 publications

Idiopathic Sudden Sensorineural Hearing Loss Is Not a Sentinel Event for Acute Myocardial Infarction

Idiopathic Sudden Sensorineural Hearing Loss Is Not a Sentinel Event for Acute Myocardial Infarction

Association of Dyslipidemia With Sudden Sensorineural Hearing Loss: A Retrospective Study

Association Between Middle Ear Cholesteatoma and Chronic Rhinosinusitis

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