Association of subclinical hypocalcemia dynamics with dry matter intake, milk yield, and blood minerals during the periparturient period

Seely, C.R.; Leno, B.M.; Kerwin, A.L.; Overton, T.R.; McArt, J.A.A.

doi:10.3168/jds.2020-19344

Cited by 32 publications

(30 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nevertheless, as our study included only 2 herds, the external applicability of our results is limited and research including a larger number of herds is needed. Furthermore, recent research suggests that postpartum blood Ca dynamics (persistent, transitory, delayed) is what determines future productive performance rather than a single blood Ca assessment as performed in the present study (McArt and Neves, 2020;Seely et al, 2021).…”

Section: Discussionmentioning

confidence: 85%

“…But later, as proposed by Neves (2020) andCouto Serrenho et al (2021), low blood Ca concentration could indicate cows' inability to adapt to increased Ca demands, or reflect lower feed intake, inflammation, or disease. In a recent study, Seely et al (2021) observed that cows with persistent (Ca ≤1.95 at 1 DIM and ≤2.20 mmol/L at 4 DIM) and delayed (Ca ≤2.2 mmol/L at 4 DIM) subclinical hypocalcemia had statistically and numerically lower DMI, respectively, compared with normocalcemic cows. Only Østergaard and Larsen (2000) reported ECM yield, which, contrary to our findings, was not associated with plasma Ca concentration assessed within 12 h postpartum.…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Association of low serum calcium concentration after calving with productive and reproductive performance in multiparous Jersey cows

Valldecabres

Silva-del-Río

2021

Journal of Dairy Science

View full text Add to dashboard Cite

Consequences of postpartum low blood calcium (Ca) concentration are still under study and literature describing this condition in Jersey cows is scarce. A prospective cohort study was conducted to evaluate the association of low serum Ca concentration shortly after calving with milk and energy-corrected milk yields, somatic cell count linear score, and pregnancy to first service and within 150 d in milk in multiparous Jersey cows from 2 commercial herds. Blood samples for serum Ca determination were collected on average at 3 h 10 min postpartum from 352 multiparous Jersey cows. Productive data up to the 10th monthly test were obtained from the Dairy Herd Improvement Association and reproductive data were obtained from herd records. Multiple linear, log-binomial, and Cox's proportional hazards regressions were used to evaluate the association of low serum Ca concentration with productive and reproductive outcomes. Serum Ca concentration ≤2.18 mmol/L was associated with 1.43 and 1.85 kg/d more milk and energy-corrected milk. However, lower serum Ca concentrations were associated with a 0.28-unithigher somatic cell count linear score per monthly test (Ca ≤2.00 mmol/L), and decreased pregnancy risk at first service (risk ratio = 0.64; Ca ≤1.94 mmol/L) and hazard of pregnancy within 150 d in milk (hazard ratio = 0.40; Ca ≤1.90 mmol/L). The present study is based on a convenience sample of multiparous Jersey cows from 2 commercial herds; further research including more herds and additional blood Ca determinations is needed to describe postpartum blood Ca dynamics and its association with productive and reproductive outcomes for the Jersey breed.

show abstract

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 96%

Association of low serum calcium concentration after calving with productive and reproductive performance in multiparous Jersey cows

Valldecabres

Silva-del-Río

2021

Journal of Dairy Science

View full text Add to dashboard Cite

show abstract

“…However, no significant differences were detected between treatments. These results are unsurprising, considering that this experiment was not powered to analyze milk yield, but they pose interesting consideration when discussing blood calcium, DMI, and milk yield in the current study, as transient hypocalcemia in the immediate days postpartum has been associated with increased milk production when compared with normocalcemic cows (McArt and Neves, 2020), despite a lack of change in DMI (Seely et al, 2021).…”

Section: Discussionmentioning

confidence: 85%

Physiological adaptations in early-lactation cows result in differential responses to calcium perturbation relative to nonlactating, nonpregnant cows

Connelly

Henschel

Kuehnl

et al. 2022

Journal of Dairy Science

View full text Add to dashboard Cite

The peripartal cow experiences a rapid change in calcium metabolism at the onset of lactation. Research has focused on understanding how mammary-derived factors, such as serotonin (5HT) and parathyroid hormone like hormone (PTHLH), aid in coordinating these calcemic adaptations to lactation. Therefore, the aim of our study was to determine how induced subclinical hypocalcemia influences physiological responses, specifically the 5HT-PTHLH-Ca axis, in lactating and nonlactating dairy cows to elucidate the potential contribution of the mammary gland. Twelve nonlactating, nonpregnant (NL) multiparous Holstein cows and 12 early-lactation (EL) multiparous Holstein cows received either (1) a continuous 24-h intravenous solution of 0.9% NaCl or (2) 5% ethylene glycol tetraacetic acid (EGTA) solution in 0.9% NaCl (n = 6 EL, n = 6 NL per treatment) with the aim of maintaining blood ionized calcium (iCa) less than 1.0 mM. Mammary gland biopsies were taken immediately after and 48 h after termination of infusion. Blood was sampled hourly during infusion and 4, 8, 12, 24, 48, and 72 h after termination of infusion. Infusion of EGTA successfully decreased blood iCa concentrations. However, EL EGTA-infused cows required increased rates of EGTA infusion to maintain iCa below 1.0 mM. Circulating and mammary serotonin concentrations were increased in EL relative to NL cows, with no difference as a result of EGTA infusion. Mammary PTHLH expression was increased in EL cows, with highest expression observed in EL EGTA-infused cows. Collectively, these data demonstrate the robust adaptations EL cows have to maintain Ca homeostasis and the supporting roles 5HT and PTHLH may play.

show abstract

“…The major criticism is the lack of a clear PTH threshold for both calcium and vitamin D supplementation. Some authors suggest that PTH may not be the only determinant for the development of hypocalcemia and that other factors may play a major role such as vitamin D deficiency [40], dietary habits [41], and other metabolic disorders such as hypomagnesemia [42,43]. Hypomagnesemia is frequently associated with the use of drugs such as aminoglycosides, cyclosporine, cisplatin, amphotericin B, ACE inhibitors, proton pump inhibitors, and some diuretics (thiazides and loop) [44].…”

Section: Discussionmentioning

confidence: 99%

PTH after Thyroidectomy as a Predictor of Post-Operative Hypocalcemia

Metere¹,

Biancucci

Natili³

et al. 2021

Diagnostics

View full text Add to dashboard Cite

Post-thyroidectomy hypocalcemia is a frequent complication with significant morbidity, and has been shown to increase hospital stay and readmission rates. The evaluation of serum parathyroid hormone (PTH) levels after thyroidectomy represents a reliable method to predict post-thyroidectomy hypocalcemia, but it remains infrequently used. This retrospective study investigates serum PTH values 3 h after thyroidectomy as a predictor of hypocalcemia. In this study, we enrolled 141 patients aged between 27 and 71 years eligible for total thyroidectomy who presented with multinodular goiter, suspicious nodule on cytological examination, Graves’ disease, or toxic multinodular goiter. Three hours after total thyroidectomy, 53 patients (37.6%) showed a reduction in serum PTH. Of these patients 75.5% developed hypocalcemia by 24 h after surgery and 100% were hypocalcemic after 48 h (p < 0.001). There was no significant difference attributable to the different thyroid diseases, nor to the age of the patients. PTH at 3 h after total thyroidectomy accurately predicts post-operative hypocalcemia. The early detection of patients at risk of developing post-operative hypocalcemia allows for prompt supplementation of calcium and Vitamin D in order to prevent symptoms and allows for a safe and timely discharge.

show abstract

Association of subclinical hypocalcemia dynamics with dry matter intake, milk yield, and blood minerals during the periparturient period

Cited by 32 publications

References 35 publications

Association of low serum calcium concentration after calving with productive and reproductive performance in multiparous Jersey cows

Association of low serum calcium concentration after calving with productive and reproductive performance in multiparous Jersey cows

Physiological adaptations in early-lactation cows result in differential responses to calcium perturbation relative to nonlactating, nonpregnant cows

PTH after Thyroidectomy as a Predictor of Post-Operative Hypocalcemia

Contact Info

Product

Resources

About