Association of Stein-Leventhal syndrome with the incidence of postmenopausal breast carcinoma in a large prospective study of women in Iowa

Anderson, Kristin E.; Sellers, Thomas A.; Chen, Ping-Ling; Rich, Stephen S.; Hong, Ching Ping; Folsom, Aaron R.

doi:10.1002/(sici)1097-0142(19970201)79:3<494::aid-cncr10>3.0.co;2-z

Cited by 92 publications

(30 citation statements)

References 23 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Again, this association seems to be consistent only in group I women. Strikingly, the relationships between PCOS and some gynecological tumors have been previously stated (37)(38)(39)(40). In any case, to determine the precise role of CAPN10 haplotypes in cancer susceptibility, new molecular genetic studies, in specific cohorts of cancer patients, must be performed.…”

Section: Discussionmentioning

confidence: 99%

Specific CAPN10 Gene Haplotypes Influence the Clinical Profile of Polycystic Ovary Patients

González

Abril

Roca

et al. 2003

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

Recently, several research groups have evaluated CAPN10 gene in polycystic ovarian syndrome (PCOS) patients and other phenotypes, including hirsutism or intermediate phenotypes of PCOS. Molecular genetic analysis of CAPN10 gene indicates that different alleles may play a role in PCOS susceptibility and could be associated with idiopathic hirsutism. However, these observations are not exempt from controversy, because independent studies cannot replicate these preliminary findings. We present a haplotype-phenotype correlation study of CAPN10 haplotypes in 148 women showing ecographically detected polycystic ovaries (PCO) combined with one or more of these clinical symptoms: amenorrhea or severe oligomenorrhea, hyperandrogenism, and anovulatory infertility, as well as 93 unrelated controls. We have reconstructed and analyzed 482 CAPN10 haplotypes in patients and controls. We detected the association of UCSNP-44 allele with PCO phenotype in the Spanish population (P = 0.02). In addition, we identified several CAPN10 alleles associated to phenotypic differences observed between PCO patients, such as the presence of hypercholesterolemia (haplotype 1121, P = 0.005), presence of hyperandrogenic features (P = 0.05), and familial cancer incidence (haplotype 1111, P = 0.0005). Our results confirm the association of UCSNP-44 allele with PCO phenotype in the Spanish population. Moreover, we have identified novel candidate risk alleles and genotypes, within CAPN10 gene, that could be associated with important phenotypic and prognosis differences observed in PCOS patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Specific CAPN10 Gene Haplotypes Influence the Clinical Profile of Polycystic Ovary Patients

González

Abril

Roca

et al. 2003

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

show abstract

“…Most of the studies have shown no significant increase in odds ratios or relative risk ratios between quartiles of serum T levels and breast cancer, especially when adjusted for other variables such as age, body mass index, age of menarche, family history of breast cancer, and E 2 levels (131,132,(134)(135)(136)(137)(138)(139)(140)(141)(142), while a few have shown increased risk with increasing T levels (133,(143)(144)(145)(146), even when corrected for E 2 levels (133,(144)(145)(146). Prospective cohort and case-control studies of women with polycystic ovarian disease and endogenous hyperandrogenism have not shown an increased risk of breast cancer, which provides additional evidence that elevated serum T concentrations are not a risk factor for breast cancer (147)(148)(149).…”

Section: Breast Cancermentioning

confidence: 99%

Safety of testosterone treatment in postmenopausal women

Braunstein¹

2007

Fertility and Sterility

View full text Add to dashboard Cite

“…One exception is PCOS, which has been specifically addressed in some studies. A report of increased risk associated with PCOS in postmenopausal women in a cohort with chronic anovulation [6] was followed by an inverse finding in younger women [9] and two null reports [7,8]. In general, the prevalence of PCOS was quite low in these studies.…”

Section: Discussionmentioning

confidence: 98%

“…Benign neoplastic tumours such as cystic teratomas and serous cystadenomas are sometimes grouped with other ovarian cyst types. Polycystic ovary syndrome (PCOS), with multiple small cysts associated with high levels of androgens, has been evaluated as a potential risk factor for breast cancer with mixed results with findings of both increased and decreased risk as well as null results [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Ovarian cysts and breast cancer: results from the Women’s Contraceptive and Reproductive Experiences Study

Knight

Lesosky

Blackmore

et al. 2007

Breast Cancer Res Treat

View full text Add to dashboard Cite

A diagnosis of ovarian cysts is likely an indicator of hormonal milieu and thus may be related to breast cancer risk. Recent studies have reported an inverse relationship between prior ovarian cyst diagnosis and breast cancer risk. We evaluated this relationship in the Women's Contraceptive and Reproductive Experiences (CARE) Study, a population-based case-control study conducted in Atlanta, Detroit, Philadelphia, Los Angeles, and Seattle. Cases had first primary invasive breast cancer diagnosed between 1994 and 1998 at ages 35-64 years. African American women were over-sampled. Controls were identified through random digit dialling and were frequency matched to cases on centre, race, and five-year age group. A total of 4575 cases and 4682 controls were interviewed. We used unconditional logistic regression adjusted for age and study centre within racial groups to estimate the odds ratio (OR) and 95% confidence interval (CI) for the relationship between prior ovarian cysts and breast cancer. Ovarian cyst diagnosis was associated with a significantly reduced risk among Caucasians (OR=0.85, 95% CI 0.76-0.96) and among African Americans (OR=0.68, 95% CI 0.57-0.81). The association in Caucasians was not significant within subgroups defined by menopausal status, hormone use, or gynecological surgery while the OR estimates in African Americans were consistently lower and frequently significant. These data are consistent with the previously reported inverse association between ovarian cysts and breast cancer, but the evidence for a relationship was stronger in African Americans than Caucasians. Additional studies are required to determine the specific cyst type(s) responsible for the observed relationship.

show abstract

Association of Stein-Leventhal syndrome with the incidence of postmenopausal breast carcinoma in a large prospective study of women in Iowa

Cited by 92 publications

References 23 publications

Specific CAPN10 Gene Haplotypes Influence the Clinical Profile of Polycystic Ovary Patients

Specific CAPN10 Gene Haplotypes Influence the Clinical Profile of Polycystic Ovary Patients

Safety of testosterone treatment in postmenopausal women

Ovarian cysts and breast cancer: results from the Women’s Contraceptive and Reproductive Experiences Study

Contact Info

Product

Resources

About