Association of spontaneous expulsion with C-reactive protein and other clinico-demographic factors in patients with lower ureteric stone

Jain, Amit; Sreenivasan, Sreerag Kodakkattil; Manikandan, Ramanitharan; Dorairajan, Lalgudi Narayanan; Sistla, Sujatha; Adithan, Subathra

doi:10.1007/s00240-019-01137-x

Cited by 7 publications

(7 citation statements)

References 26 publications

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“…with their calculated CRP cutoff values of 2.19 mg/dl, 2.45 mg/dl, and 0.41 mg/dl, respectively. [ 13 26 34 ] In our study, the cut off value was 1.35 mg/dL. The low cut off value of CRP in Jain et al .…”

Section: Discussioncontrasting

confidence: 46%

“…[ 7 14 16 28 ] Analyzing age and gender as factors for predicting stone passage after MET were statistically insignificant (“P” =0.42 and 0.64, respectively) similar to previous studies. [ 26 27 ] In our study, 78.6% (151/192) patients with distal ureteric calculus of size more than 5 mm passed stone after 4 weeks of MET. Those patients who failed MET underwent ureterorenoscopy (URS).…”

Section: Discussionmentioning

confidence: 67%

“…[ 12 16 ] In our study, there was no significant difference in the stone expulsion rate between right and left sided stones ( P = 0.59) similar to the studies by Puntub and Lerdpraiwan and Jain et al . [ 26 27 ] Miller and Kane reported the need of intervention was less likely in right sided stones. [ 18 ] In contrast, a study by Sfoungaristos et al ., spontaneous passage rate was more on left-sided stones possibly due to no firm attachment of left ureter to parietal peritoneum.…”

Section: Discussionmentioning

confidence: 99%

“…'s study could be possibly due to the exclusion of the confounding factor of elderly age as CRP increases with age and their study population included patients <50 years of age. [ 26 ]…”

Section: Discussionmentioning

confidence: 99%

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Role of inflammatory markers and their trends in predicting the outcome of medical expulsive therapy for distal ureteric calculus

et al. 2022

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Objective: Symptomatic ureteric stones cause surrounding inflammation-promoting obstruction. C-reactive protein (CRP), white blood cell count (WC), and neutrophil percentage (NP) tend to rise after inflammatory response. Monitoring response during the course of medical expulsive therapy (MET) may help in deciding early intervention, thereby decreasing morbidity. We assessed the role and trends of these markers in predicting the outcome of MET. Materials and Methods: One hundred and ninety-two patients with distal ureteric calculus of size >5 mm were included in this prospective study from April 2017 to March 2018 after ethical committee approval. CRP, NP, and WC were measured on day 1, 7, and 14 of MET, and analysis was done. Results: On univariate analysis, stone size and mean values of CRP, WC, and NP on day 1, 7 and 14 in stone nonpassers were significantly higher compared to stone passers ( P < 0.05). Receiver operator curve analysis showed area under the curve value of 0.798 ( P = 0.001) for CRP and cut off value determined was 1.35 mg/dL. Multivariate analysis of different variables showed significant association of higher CRP (>1.35 mg/dL) and larger stone size (>7 mm) with MET failure. Decreasing trend of CRP was seen in both groups, but values were higher in stone nonpassers. WC and NP showed decreasing trend in stone passers but persistently high in stone nonpassers. Conclusions: Higher CRP and larger stone size were associated with failure of MET. WC and NP showed decreasing trend in stone passers and persistently higher in nonpassers, which may potentially predict failure of MET, however, their role need to be further studied.

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Section: Discussioncontrasting

confidence: 46%

Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

“…'s study could be possibly due to the exclusion of the confounding factor of elderly age as CRP increases with age and their study population included patients <50 years of age. [ 26 ]…”

Section: Discussionmentioning

confidence: 99%

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Role of inflammatory markers and their trends in predicting the outcome of medical expulsive therapy for distal ureteric calculus

et al. 2022

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“…Presence of hydronephrosis is another factor assessed in the prediction of SSP. Several studies have shown that hydronephrosis status is significantly associated with SSP [9,20,22,23]. However, the role of a urolithiasis history in predicting SSP remains controversial.…”

Section: Discussionmentioning

confidence: 99%

What is the role of inflammatory markers in predicting spontaneous ureteral stone passage?

Senel

Aykanat²,

Asfuroglu

et al. 2022

Aktuelle Urol

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Purpose: To investigate the role of inflammatory markers in predicting the spontaneous passage of ureteral stones. Methods: We retrospectively reviewed 279 patients with ureteral stones sized 4–10 mm that were managed conservatively. The patients were divided into two groups: Group 1 consisted of 137 patients who passed the stone spontaneously; Group 2 comprised 142 patients without spontaneous stone passage. The groups were compared using the Mann-Whitney U and chi-square tests. In addition, univariate and multivariate analyses were performed to identify the significance of the parameters. Results: The mean age of the patients was 41.2 years. The patients in Group 1 had a significantly lower mean stone size, white blood cell count and neutrophil count. In addition, stone location, presence of hydronephrosis and history of urolithiasis were significantly different between the groups. Neutrophil percentage, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio were insignificantly lower in Group 1. In a multivariate analysis, stone size, distal location and hydronephrosis status significantly predicted the spontaneous stone passage. However, inflammatory markers including white blood cell count, neutrophil count and neutrophil-to-lymphocyte ratio could not determine the likelihood of spontaneous stone passage. Conclusion: Our results suggest that inflammatory markers are no meaningful parameters for the prediction of spontaneous stone passage.

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CT-related parameters and Framingham score as predictors of spontaneous passage of ureteral stones ≤ 10 mm: results from a prospective, observational, multicenter study

et al. 2020

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Association of spontaneous expulsion with C-reactive protein and other clinico-demographic factors in patients with lower ureteric stone

Cited by 7 publications

References 26 publications

Role of inflammatory markers and their trends in predicting the outcome of medical expulsive therapy for distal ureteric calculus

Role of inflammatory markers and their trends in predicting the outcome of medical expulsive therapy for distal ureteric calculus

What is the role of inflammatory markers in predicting spontaneous ureteral stone passage?

CT-related parameters and Framingham score as predictors of spontaneous passage of ureteral stones ≤ 10 mm: results from a prospective, observational, multicenter study

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