Association of single nucleotide polymorphisms of adiponectin and leptin genes with breast cancer

Geriki, Sarvari; Bitla, Aparna R.; Srinivasarao, P; Hulikal, Narendra; Yootla, Mutheeswaraiah; Sachan, Alok; Yadagiri, Lakshmi Amancharla; Asha, T.; Manickavasagam, M; Kannan, T; Kumari, Aruna P

doi:10.1007/s11033-019-05070-5

Cited by 5 publications

(6 citation statements)

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“…Changes due to an obesity environment may further alter breast cancer risk in such genetic alterations 78 . In particular, the single nucleotide polymorphisms (SNPs) rs1501299 and rs2241766 have been associated with altered circulating adiponectin levels and are predictors of increased breast cancer risk 78–81 . Further, Pasha et al.…”

Section: Methodsmentioning

confidence: 99%

“…78 In particular, the single nucleotide polymorphisms (SNPs) rs1501299 and rs2241766 have been associated with altered circulating adiponectin levels and are predictors of increased breast cancer risk. [78][79][80][81] Further, Pasha et al found that in patients with obese women with breast cancer, epigenetic regulation of ADIPQ via promoter site methylation is associated with altered disease risk. 80 The role of resistin in breast cancer stemness and migration…”

Section: Anti-inflammatory Effects Of Adiponectin Confer a Protective...mentioning

confidence: 99%

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The impact of obesity and adipokines on breast and gynecologic malignancies

Tewari

Vargas

Reizes

2022

Annals of the New York Academy of Sciences

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The link between obesity and multiple disease comorbidities is well established. In 2003, Calle and colleagues presented the relationship between obesity and several cancer types, including breast, ovarian, and endometrial malignancies. Nearly, 20% of cancer‐related deaths in females can be accounted for by obesity. Identifying obesity as a risk factor for cancer led to a focus on the role of fat‐secreted cytokines, known as adipokines, on carcinogenesis and tumor progression. Early studies indicated that the adipokine leptin increases cell proliferation, invasion, and inhibition of apoptosis in multiple cancer types. As a greater appreciation of the obesity–cancer link has amassed, we now know that additional adipokines can impact tumorigenesis. A deeper understanding of the adipokine‐activated signaling in cancer may identify new treatment strategies irrespective of obesity. Moreover, adipokines may serve as disease biomarkers, harnessing the potential of obesity‐associated factors to serve as indicators of treatment response and disease prognosis. As studies investigating obesity and women's cancers continue to expand, it has become evident that breast, ovarian, and uterine cancers are distinctly impacted by adipokines. While complex, these distinct interactions may provide insight into cancer progression in these organs and new opportunities for targeted therapies. This review aims to organize and present the literature from the last 5 years investigating the mechanisms and implications of adipokine signaling in breast, endometrial, and ovarian cancers with a special focus on leptin and adiponectin.

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Section: Methodsmentioning

confidence: 99%

Section: Anti-inflammatory Effects Of Adiponectin Confer a Protective...mentioning

confidence: 99%

The impact of obesity and adipokines on breast and gynecologic malignancies

Tewari

Vargas

Reizes

2022

Annals of the New York Academy of Sciences

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“…Initial search of 4 public datasets identified a total of 596 publications after deleting duplicates. Only 33 of these publications were eligible for inclusion (10,. The selection process of eligible articles was displayed in the form of flow diagram (Figure 1).…”

Section: Eligible Studiesmentioning

confidence: 99%

“…Evaluating genes with definitive biological function and direct implications in breast carcinogenesis represents a good alternative. Echoing this claim, obesity-related cytokines such as leptin and adiponectin are increasingly recognized as promising candidates in the development of breast cancer (10).…”

Section: Introductionmentioning

confidence: 99%

Genetic alterations in LEP and ADIPOQ genes and risk for breast cancer: a meta-analysis

Peng

Liu

et al. 2023

Front. Oncol.

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IntroductionBreast cancer has a strong genetic predisposition, and its genetic architecture is not fully understood thus far. In this study, we aimed to perform a meta-analysis to evaluate the association of genetic alterations in LEP and ADIPOQ genes, as well as their receptor-encoded genes with risk for breast cancer. MethodsOnly published studies conducted in humans and written in English were identified by searching PubMed, SCOPUS, CINAHIL and Embase from their inception to October 2022. Eligibility assessment and data collection were completed independently by two researchers. Statistical analyses were done using the STATA software. ResultsAfter literature search, 33 publications were eligible for inclusion. Overall, LEP gene rs7799039-G allele (odds ratio [OR]: 0.78, 95% confidence interval [CI]: 0.62 to 0.98) and ADIPOQ gene rs1501299-T allele (OR: 1.41, 95% CI: 1.06 to 1.88) were associated with the significant risk of breast cancer. In subgroup analyses, differences in menopausal status, obesity, race, study design, diagnosis of breast cancer, genotyping method and sample size might account for the divergent observations of individual studies. Circulating leptin levels were comparable across genotypes of LEP gene rs7799039, as well as that of LEPR gene rs1137101 (P>0.05). Begg’s funnel plots seemed symmetrical, with the exception of LEPR gene rs1137100 and ADIPOQ gene rs1501299. DiscussionTaken together, we found, in this meta-analysis, that LEP gene rs7799039 and ADIPOQ gene rs1501299 were two promising candidate loci in predisposition to breast cancer risk.

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“…Par ailleurs, l'expression du récepteur de l'adiponectine AdipoR2 serait plus élevée dans le tissu mammaire cancéreux par rapport au tissu sain et serait corrélée positivement à l'invasion lymphovasculaire. Des études moléculaires suggèrent également que des polymorphismes dans le gène de l'adiponectine ou de son récepteur pourraient être associés à un risque accru du cancer du sein à l'instar de la substitution G → T (+ 276G/T) (rs1501299) dans l'intron 2 du gène de l'adiponectine qui serait corrélée à un risque accru de cancer du sein en modulant les concentrations circulantes d'adiponectine [60]. Différentes études in vitro sont venues étayer le rôle de l'adiponectine dans l'inhibition de la tumorigenèse tels que les travaux de Wang et al qui ont montré que l'adiponectine atténuait de manière significative la prolifération de deux lignées cancéreuses mammaires MDA-MB-231 et T47D [61].…”

Section: Adiponectine Et Cancerunclassified

Mutltifaceted biological roles of adiponectin

Cuerq¹,

Morineau²,

Dufour‐Rainfray³

et al. 2020

Annales De Biologie Clinique

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Association of single nucleotide polymorphisms of adiponectin and leptin genes with breast cancer

Cited by 5 publications

References 36 publications

The impact of obesity and adipokines on breast and gynecologic malignancies

The impact of obesity and adipokines on breast and gynecologic malignancies

Genetic alterations in LEP and ADIPOQ genes and risk for breast cancer: a meta-analysis

Mutltifaceted biological roles of adiponectin

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