Association of Severity of Hypertension and Periodontitis: PP.20.296

Grassos, C.; Gourlis, D.; Papaspyropoulos, Anastasios; Spyropoulos, Alex C.; Kranidis, Athanasios; Almagout, P; Pisogiannakis, A

doi:10.1097/01.hjh.0000379222.70938.e9

Cited by 1 publication

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“…Ultimately, more studies are suggested to investigate the effect of periodontal disease and its treatment, in healthy and systemically diseased individuals, on the overall coagulation activation process output which is presented by thrombin activation using advanced thrombin generation assays such as the calibrated automated thrombogram that would help in assessing additional meticulous markers such as the microparticles levels that play, like thrombin, a role in both of the inflammatory and coagulation process, which would enhance more strict prophylactic procedures when treating health-compromised individuals. [4243]…”

Section: Discussionmentioning

confidence: 99%

Effect of surgical and non-surgical periodontal debridement on vascular thrombotic markers in hypertensives

Albush¹,

Razan²,

Dieri³

2013

J Indian Soc Periodontol

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Background:Periodontal debridement has an impact on the vascular thrombotic markers in healthy individuals. This study aimed to investigate changes in several vascular thrombotic markers after surgical and non-surgical periodontal debridement in hypertensives with periodontitis.Materials and Methods:40 hypertensives, 27 males and 13 females, 37-68 year old, mean 51.2 years, with moderate to severe periodontitis, were divided into two groups, (n = 20 for each); the first received comprehensive one session non-surgical periodontal debridement, (pockets 4-6 mm), while the second received comprehensive supragingival scaling with surgical debridement at one quadrant, (Pockets > 6 mm). Periodontal parameters included; plaque index (PI), gingival inflammation (GI), bleeding on probing (BOP), pocket probing depth (PPD). Vascular thrombotic tests included; platelets count (Plt), fibrinogen (Fib), Von Willebrand factor antigen activity (vWF:Ag), and D-dimers (DD).Results:PI, GI, BOP, PPD, decreased significantly (P = 0.001) after 6 weeks of periodontal debridement in both groups, while BOP and PPD remained higher in the surgical one (P < 0.05). Thrombotic vascular markers changes through the three-time intervals were significant in each group (P = 0.001), and time-group interception effect was significant for vWF:Ag (P = 0.005), while no significant differences between groups after treatment (P > 0.05).Conclusion:Periodontal debridement, surgical and non-surgical, improved the periodontal status in hypertensives. Periodontal treatment activated the coagulation system in hypertensives and recessed later while the treatment modality did not affect the degree of activation.

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Section: Discussionmentioning

confidence: 99%