Effect of surgical and non-surgical periodontal debridement on vascular thrombotic markers in hypertensives

Albush, Muhammad M; Razan, Khattab K; Dieri, Raed Al

doi:10.4103/0972-124x.115654

Cited by 5 publications

(4 citation statements)

References 26 publications

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“…Good periodontal health may be associated with better BP control during antihypertensive treatment [38]. The effects of NSPT in hypertensive individuals have been reported in a few studies [26][27][28]39]. In our study, the NSPT of individuals with RAH proved to be beneficial during the 90 and 180-day evaluations.…”

Section: Discussionsupporting

confidence: 59%

The Effect of Non-surgical Periodontal Treatment on Patients With Combined Refractory Arterial Hypertension and Stage Iii, Grade B Periodontitis: A Preliminary Prospective Clinical Study

Rodrigues¹,

Cláudio²,

Franciscon³

et al. 2023

Preprint

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We sought to evaluate the effects of non-surgical periodontal treatment (NSPT) on periodontal clinical parameters, systemic blood pressure (BP) and plasma levels of systemic inflammation markers in patients with combined refractory arterial hypertension (RAH) and stage III grade B periodontitis. Twenty-seven participants with RAH and periodontitis received NSPT. The analyzed clinical parameters were probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), and plaque index (PI). An assessment was performed for systemic BP, complete blood count, coagulogram, creatinine measurement, C-reactive protein (CRP), glycated hemoglobin, cholesterol, glutamic oxaloacetic transaminase, glutamate pyruvic transaminase, waist-hip ratio, and body mass index. In the follow-up period, twenty-two patients were evaluated at baseline and after 90 and 180 days. The data were submitted to statistical analysis (α=0.05%). As expected, the clinical results showed a significant improvement in the percentages of PI, BOP, PD and CAL, which were statistically significant at 90 and 180 days (p&lt;0.0001). Importantly, NSPT significantly reduced the blood level of CRP (p&lt;0.02). However, no significant reduction in BP parameters was noted in the evaluated follow-up periods. NSPT, despite the benefits in periodontal clinical parameters, reduced the plasma level of CRP but not the BP in patients with combined RAH and periodontitis.

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Section: Discussionsupporting

confidence: 59%

The Effect of Non-surgical Periodontal Treatment on Patients With Combined Refractory Arterial Hypertension and Stage Iii, Grade B Periodontitis: A Preliminary Prospective Clinical Study

Rodrigues¹,

Cláudio²,

Franciscon³

et al. 2023

Preprint

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show abstract

“…These results are consistent with our study; however, in this investigation, non-surgical periodontal therapy was performed in all the patients in the study. [ 19 ]…”

Section: Discussionmentioning

confidence: 99%

Systemic inflammatory response to non-surgical treatment in hypertensive patients with periodontal infection

Arregocés¹,

Rada

Martinez

et al. 2021

Medicine

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Hypertension is associated with chronic inflammation in the tissues and organs that are involved in the regulation of arterial pressure, such as kidneys and blood vessels. Periodontal disease affects systemic inflammatory markers, leading to endothelial dysfunction, atherosclerotic plaque instability, dyslipidaemia, and insulin resistance. These conditions can also cause an increase in the blood pressure. Nonsurgical periodontal therapies, such as scaling and root planning, can affect systemic markers of inflammation. We evaluated the effect of scaling and root planning on serum levels of inflammation biomarkers in hypertensive patients. The sample consisted of 19 hypertensive patients with Periodontitis. The patients underwent laboratory tests that included glycaemia, cholesterol, triglycerides and blood count. Blood pressure was measured before periodontal therapy, and the second blood pressure recording was obtained at the re-evaluation appointment. Quantification of peripheral blood cytokines was performed using the Milliplex Inflammation Human Cytokine kit (Interleukin 1-β, Interleukin-4, Interleukin-6, Interleukin-8, Interleukin-10, Interleukin-12 P70, Interleukin-17A, vascular endothelial growth factor and tumor necrosis factor-alpha). All cytokine levels decreased from the initial examination to reassessment. Cytokines that reflected a statistically significant difference included Interleukin-1β and endothelial vascular growth factor ( P = .04 and P = .004). Hypertensive patients with periodontitis undergoing non-surgical periodontal treatment exhibited a decrease in proinflammatory cytokine levels. Non-surgical periodontal treatment decreases the levels of systemic proinflammatory cytokines in controlled hypertensive patients.

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“…Good periodontal health may be associated with better BP control during antihypertensive treatment [ 42 ]. The effects of NSPT in hypertensive individuals have been reported in a few studies [ 30 , 31 , 32 , 43 ]. In our study, the NSPT of individuals with RAH proved to be beneficial during the 90- and 180-day evaluations.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Non-Surgical Periodontal Treatment on Patients with Combined Refractory Arterial Hypertension and Stage III, Grade B Periodontitis: A Preliminary Prospective Clinical Study

Rodrigues

Cláudio

Franciscon

et al. 2023

JCM

View full text Add to dashboard Cite

We sought to evaluate the effects of non-surgical periodontal treatment (NSPT) on periodontal clinical parameters, systemic blood pressure (BP), and plasma levels of systemic inflammation markers in patients with combined refractory arterial hypertension (RAH) and stage III grade B periodontitis. Twenty-seven participants with RAH and periodontitis received NSPT. The analyzed clinical parameters were probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), and plaque index (PI). An assessment was performed for systemic BP, complete blood count, coagulogram, creatinine measurement, C-reactive protein (CRP), glycated hemoglobin, cholesterol, glutamic oxaloacetic transaminase, glutamate pyruvic transaminase, waist–hip ratio, and body mass index. In the follow-up period, twenty-two patients were evaluated at baseline and after 90 and 180 days. The data were submitted for statistical analysis (α = 0.05%). As expected, the clinical results showed a significant improvement in the percentages of PI, BOP, PD, and CAL, which were statistically significant at 90 and 180 days (p < 0.0001). Importantly, NSPT significantly reduced the blood level of CRP (p < 0.02). However, no significant reduction in BP parameters was noted in the evaluated follow-up periods. NSPT, despite the benefits in periodontal clinical parameters, reduced the plasma level of CRP but not the BP in patients with combined RAH and periodontitis.

show abstract

Effect of surgical and non-surgical periodontal debridement on vascular thrombotic markers in hypertensives

Cited by 5 publications

References 26 publications

The Effect of Non-surgical Periodontal Treatment on Patients With Combined Refractory Arterial Hypertension and Stage Iii, Grade B Periodontitis: A Preliminary Prospective Clinical Study

The Effect of Non-surgical Periodontal Treatment on Patients With Combined Refractory Arterial Hypertension and Stage Iii, Grade B Periodontitis: A Preliminary Prospective Clinical Study

Systemic inflammatory response to non-surgical treatment in hypertensive patients with periodontal infection

The Effect of Non-Surgical Periodontal Treatment on Patients with Combined Refractory Arterial Hypertension and Stage III, Grade B Periodontitis: A Preliminary Prospective Clinical Study

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