Association of Serum Vitamin D Levels with Bacterial Load in Pulmonary Tuberculosis Patients

Yuvaraj, B Y; Sridhar, Magadi Gopalakrishna; Kumar, Senthil; Kadhiravan, Tamilarasu

doi:10.4046/trd.2016.79.3.153

Cited by 16 publications

(16 citation statements)

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“…A cross-sectional study done by Yuvaraj et al [ 2 ] in India, which included 65 sputum AFB positive PTB patients and 65 healthy controls, showed a significant difference in the deficiency of vitamin D with a rise in sputum smear positivity associated with a substantial negative correlation between vitamin D levels and degree of sputum smear positivity. The study concluded that the lower the vitamin D, the higher the MTB bacterial load [ 2 ]. In the present study also, we observed a significant negative correlation between vitamin D levels and degree of sputum smear positivity and levels of sputum positivity.…”

Section: Discussionmentioning

confidence: 99%

“…Based on sputum smear findings, tuberculosis was grouped into three categories [ 2 , 19 ]. +++ per hpf.…”

Section: Methodsmentioning

confidence: 99%

“…Vitamin D has a vital role in host immune defense against Mycobacterium tuberculosis (MTB). It has been observed that vitamin D induces antimicrobial peptide cathelicidin which inhibits mycobacterium multiplication in the macrophages [ 2 , 3 ]. High serum vitamin D concentrations and hypercalcemia have been described in patients with tuberculosis.…”

Section: Introductionmentioning

confidence: 99%

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Association of Vitamin D Deficiency and Newly Diagnosed Pulmonary Tuberculosis

et al. 2021

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Introduction. Vitamin D has a significant role in host immune defense against Mycobacterium tuberculosis. It has been suggested that pulmonary tuberculosis may be associated with lower levels of vitamin D. Present study was therefore undertaken to identify the association between vitamin D deficiency and pulmonary tuberculosis. Methods. A case-control study was conducted in a tertiary care hospital from 2014 to 2016, including 50 adult newly diagnosed sputum positive pulmonary tuberculosis patients as cases and 50 age and sex-matched healthy participants as control groups. All participants in the study group had undergone detailed clinical examination and routine laboratory investigations, including vitamin D, calcium, and sputum for AFB. The clinical characteristics, X-ray findings, sputum AFB, and vitamin D levels were analyzed and compared with data obtained from healthy controls. Results. In both groups, the majority were men (88%). BMI was significantly (<0.0001 ∗ ) lower in the tuberculosis group (19.40 (17.20, 22.0) vs. 24.00 (22.50, 25.47)). Serum vitamin D levels were significantly lower ( P = 0.012 ) in the tuberculosis group (19 (7.75, 27.25) ng/dl) as compared to the control group (25 (19.75, 32.00) ng/dl). Out of 50 TB patients, 27 (54%) had vitamin D deficiency, while among healthy controls, only 13 (26%) had vitamin D deficiency. Among vitamin D deficient PTB patients, 44% had 3+/hpf AFB in sputum smear examination. Conclusion. The prevalence of vitamin D deficiency in pulmonary tuberculosis cases is very high. Hypovitaminosis D was associated with more severe clinical symptoms, higher sputum smear positivity, and extensive lesions in chest radiograph among pulmonary tuberculosis patients.

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Section: Discussionmentioning

confidence: 99%

“…Based on sputum smear findings, tuberculosis was grouped into three categories [ 2 , 19 ]. +++ per hpf.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of Vitamin D Deficiency and Newly Diagnosed Pulmonary Tuberculosis

et al. 2021

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“…[21] A study done by B Yuvaraj et al evidenced the association of decreased vitamin D levels with an increase sputum AFB load in patients with tuberculosis. [22] A study conducted on Indian children with intrathoracic tuberculosis by Khandelwal et al showed that majority of the children demonstrated low serum 25hydroxyvitamin D levels. [23] A cohort study conducted in Pakistan found that vitamin D deficiency is associated with progression of latent TB to active disease in healthy household contacts.…”

Section: Section: Paediatricsmentioning

confidence: 99%

Vitamin D Status in Patients with Pulmonary Tuberculosis: A Teaching Hospital Based Study

Solanky¹,

Ansari²

2018

AIMDR

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Background: This study was designed to determine the level of vitamin D in patients with pulmonary tuberculosis. Methods: We conducted a cross sectional study on 150 subjects (75 newly diagnosed pulmonary tuberculosis and 75 healthy controls) was selected through non-probability purposive sampling according to inclusion and exclusion criteria. Results: The mean 25(OH) D level is 24.46±12.03 in cases and 36.3 ±13.41 in the controls. The difference between the means of the cases and controls were statistically significant p = 0.002 (p < 0.05). Conclusion: The patients with pulmonary tuberculosis are significantly Vitamin D deficient as compared to healthy controls. Vitamin D supplementation is warranted for patients of pulmonary tuberculosis.

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“…(21) A study conducted on Indian children with intrathoracic tuberculosis by Khandelwal et al showed that majority of the children demonstrated low serum 25-hydroxyvitamin D levels. (22) A cohort study conducted in Pakistan found that vitamin D deficiency is associated with progression of latent TB to active disease in healthy household contacts.…”

Section: (Oh) Vitamin D Levelmentioning

confidence: 99%

A Study on Vitamin D Status in Tuberculosis

Rajamanickam¹,

Biswas²,

Kar³

2017

jemds

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BACKGROUNDIndia is a country with the highest burden of TB. Vitamin D can lead to activation of immune system and prevent the growth of intracellular Mycobacterium tuberculosis. Good number of studies show that there is deficiency of Vitamin D in tuberculosis patients, though there are limited number of studies to show result on the contrary.This study was done with an aim to evaluate for any association of vitamin D with tuberculosis. MATERIALS AND METHODSThe study was undertaken with 52 number of patients newly diagnosed with tuberculosis, diagnosed by clinical criteria and usual laboratory tests. Serum samples were collected and 25-hydroxy vitamin D level was estimated in all of them using chemiluminescent immunoassay technology and compared with that of normal healthy controls. RESULTSThe study population included 52 patients (34 males and 18 females) diagnosed as TB, and healthy controls. 28 patients had pulmonary and 24 patients had extrapulmonary TB. Our study confirmed a high prevalence of vitamin D deficiency, 69.23% in patients with TB as compared to 34% of the healthy controls. The difference between the means were statistically significant with t=-2.41731 and p=0.008 (p<0.05). BACKGROUND Tuberculosis (TB) is a global pandemic that mainly affects the low-and middle-income countries. India, followed by Indonesia, China, Nigeria, Pakistan and South Africa account for 60% of the total TB statistics in the world. Despite advances in diagnostic technology and invention of new antituberculous drugs, TB continues to remain a major public health concern. In May 2014, the World Health Assembly at Geneva endorsed "The End TB Strategy" with an aim to end the global TB epidemic by 2035 with targets to reduce TB deaths by 95% and cut down the new cases by 90% and ensure that no family is burdened with catastrophic expenses due to TB. India contributes to one-quarter of the global TB burden. WHO statistics for 2015 gives an estimated incidence and prevalence of 2.2 and 2.5 million respectively for TB in India. CONCLUSION(1) TB along with HIV remains as one of the leading causes of morbidity and mortality among general population.

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Association of Serum Vitamin D Levels with Bacterial Load in Pulmonary Tuberculosis Patients

Cited by 16 publications

References 9 publications

Association of Vitamin D Deficiency and Newly Diagnosed Pulmonary Tuberculosis

Association of Vitamin D Deficiency and Newly Diagnosed Pulmonary Tuberculosis

Vitamin D Status in Patients with Pulmonary Tuberculosis: A Teaching Hospital Based Study

A Study on Vitamin D Status in Tuberculosis

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