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Internet of Things (IoT) and Network Softwarization are fast becoming core technologies of information systems and network management for the next-generation Internet. The deployment and applications of IoT range from smart cities to urban computing and from ubiquitous healthcare to tactile Internet. For this reason, the physical infrastructure of heterogeneous network systems has become more complicated and thus requires efficient and dynamic solutions for management, configuration, and flow scheduling. Network softwarization in the form of Software Defined Networks and Network Function Virtualization has been extensively researched for IoT in the recent past. In this article, we present a systematic and comprehensive review of virtualization techniques explicitly designed for IoT networks. We have classified the literature into software-defined networks designed for IoT, function virtualization for IoT networks, and software-defined IoT networks. These categories are further divided into works that present architectural, security, and management solutions. Besides, the article highlights several short-term and long-term research challenges and open issues related to the adoption of software-defined Internet of Things.

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Despite remarkable progress in the development and authorization of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a need to validate vaccine platforms for broader application. The current intramuscular vaccines are designed to elicit systemic immunity without conferring mucosal immunity in the nasal compartment, which is the first barrier that SARS-CoV-2 virus breaches before dissemination to the lung. We report the development of an intranasal subunit vaccine that uses lyophilized spike protein and liposomal STING agonist as an adjuvant. This vaccine induces systemic neutralizing antibodies, IgA in the lung and nasal compartments, and T-cell responses in the lung of mice. Single-cell RNA sequencing confirmed the coordinated activation of T/B-cell responses in a germinal center-like manner within the nasal-associated lymphoid tissues, confirming its role as an inductive site to enable durable immunity. The ability to elicit immunity in the respiratory tract can prevent the establishment of infection in individuals and prevent disease transmission.Mucosal vaccination can stimulate both systemic and mucosal immunity and has the advantage of being a non-invasive procedure suitable for immunization of large populations. However, mucosal vaccination is

Software Defined Networks has seen tremendous growth and deployment in different types of networks. Compared to traditional networks it decouples the control logic from network layer devices, and centralizes it for efficient traffic forwarding and flow management across the domain. This multilayered architecture has data forwarding devices at the bottom in data plane, which are programmed by controllers in the control plane. The high level application or management plane interacts with control layer to program the whole network and enforce different policies. The interaction among these layers is done through interfaces which work as communication/programming protocols. In this survey, we present a comprehensive study of such interfaces available for southbound, northbound, and east/westbound communication. We have classified each type into different categories based on their properties and capabilities. Virtualization of networks devices is a common practice in Software Defined Networks. This paper also analyzes interface solution which work with different virtualization schemes. In addition, the paper highlights a number of short term and long term research challenges and open issues related to SDN interfaces.