Association of Serum Uric Acid Level With Aortic Stiffness and Arterial Wave Reflections in Newly Diagnosed, Never-Treated Hypertension

Vlachopoulos, Charalambos; Xaplanteris, Panagiotis; Vyssoulis, Gregory P.; Bratsas, Athanasios; Baou, Katerina; Tzamou, Vanessa; Aznaouridis, Konstantinos; Dima, Ioanna; Lazaros, George; Stefanadis, Christodoulos

doi:10.1038/ajh.2010.111

Cited by 56 publications

(55 citation statements)

References 35 publications

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“…PWV was measured non-invasively using a validated device (Complior, Artech Medical, Pantin, France). 1 Left ventricular mass index (LVMI) and relative wall thickness were assessed by echocardiography. M-mode imaging was used for wall-thickness measurements.…”

mentioning

confidence: 99%

Uric acid levels, left ventricular mass and geometry in newly diagnosed, never treated hypertension

et al. 2011

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mentioning

confidence: 99%

Uric acid levels, left ventricular mass and geometry in newly diagnosed, never treated hypertension

et al. 2011

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“…In patients with hypertensive chronic kidney disease, uric acid level was associated with only AIx@75, but not with PWV [49]. However, in newly diagnosed and untreated hypertensive patients, uric acid level was associated with PWV but not with AIx [50,51]. This phenomenon was also observed in patients in the active phase of Adamantiades-Behçet's disease.…”

Section: Augmentation Index and Markers Of Arterial Stiffness In Ctdsmentioning

confidence: 58%

Augmentation Index in Connective Tissue Diseases

Choi

Kim

2017

J Rheum Dis

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Atherosclerosis and its complications are often reported in patients with connective tissue diseases (CTDs) showing chronic inflammation. Traditional cardiovascular risk factors do not account for accelerated atherosclerosis in patients with CTDs. Inflammation, although non-traditional, is considered one of the risk factors for endothelial dysfunction, atrial stiffness, and atherosclerosis. Therefore, it is essential to evaluate other risk factors for cardiovascular disease (CVD) in patients with CTDs. The interest in pulse wave analysis (PWA) is growing because of its predictive value for CVD. The arterial pressure waveform is a composite of an incidental wave produced by a ventricular contraction and a reflected wave. The wave reflection can be quantified using the augmentation index (AIx); it is defined as the difference between the inflection and peak systolic pressure, and expressed as a percentage of the pulse pressure. The PWA is represented by AIx. Risk score systems, such as the Framingham scoring system, were correlated with AIx. Many studies have analyzed the ability of the AIx to predict the CAD severity in the general population. In patients with CTDs, the AIx was found to increase compared to a healthy control group. The AIx was related to the activity of CTDs. The treatment for inflammation appeared to improve the AIx in some CTDs. Although more studies will be needed to obtain conclusive evidence, AIx is expected to be a prognostic factor or a risk factor for CVD in patients with CTDs. (J Rheum Dis 2017;24:185-191)

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“…Esen and coworkers proposed that UA is a marker of dilatation in the ascending aorta mediated by oxidative stress (Esen et al 2011). A significant association between serum UA levels, aortic stiffness and arterial wave reflections was demonstrated (Vlachopoulos et al 2011). Increased UA concentration has also been demonstrated in patients with coronary aneurysmal lesions (Sen et al 2009).…”

Section: Discussionmentioning

confidence: 95%

“…Recent studies identified possible roles of uric acid (UA) induced oxidative stress and increased inflammatory status in the pathogenesis of AscAA (Medina et al 2010;Sen et al 2009;Esen et al 2011;Vlachopoulos et al 2011). We hypothesized that cardiac adipose tissue may be involved in ascending aortic dilatation due to local or systemic effects.…”

mentioning

confidence: 99%

Increased Epicardial Adipose Tissue Thickness Is Correlated with Ascending Aortic Diameter

Çanğa

Kocaman

Çetin

et al. 2012

Tohoku J. Exp. Med.

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Epicardial adipose tissue (EAT), localized beneath the visceral pericardium, is a metabolically active endocrine and paracrine organ with possible interactions within the heart. Recent studies identified possible roles of uric acid (UA)-induced oxidative stress and increased inflammatory status in the pathogenesis of ascending aortic dilatation. The aim of this study was to investigate whether EAT is an independent factor for ascending aortic dilatation. The patients were evaluated by a complete transthoracic echocardiographic examination including measurements of EAT and aortic dimensions. Serum levels of UA and C-reactive protein and EAT thicknesses were compared in 38 patients with dilated ascending aorta (DAA) (the diameter ≥ 37 mm) vs. 107 subjects with normal aortic diameter (AD) of < 37 mm. EAT thickness was significantly higher in DAA group compared to normal AD group (8.3 ± 2.7 vs. 5.4 ± 2.2 mm, p < 0.001) as well as age (53 ± 10 vs. 48 ± 9 years, p = 0.004), the presence of hypertension (54% vs. 30%, p = 0.009) and UA levels (6.0 ± 1.4 vs. 5.2 ± 1.1 mg/dL, p < 0.001). There was a strong correlation between EAT thickness and ascending aortic diameter (r = 0.521, p < 0.001). In multiple logistic regression analysis, EAT thickness (OR: 1.429, p = 0.006), body mass index (OR: 1.169, p = 0.014) and UA levels (OR: 1.727, p = 0.023) were independently correlated to ascending aortic dilatation. We therefore propose that increased EAT thickness is an independent predictor of ascending aortic dilation.

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Association of Serum Uric Acid Level With Aortic Stiffness and Arterial Wave Reflections in Newly Diagnosed, Never-Treated Hypertension

Abstract: Serum UA levels are independently associated with aortic stiffening and wave reflections in never-treated hypertensives. Future studies are warranted in order to explore its exact role on arterial function in the hypertensive setting.

Cited by 56 publications

References 35 publications

Uric acid levels, left ventricular mass and geometry in newly diagnosed, never treated hypertension

Uric acid levels, left ventricular mass and geometry in newly diagnosed, never treated hypertension

Augmentation Index in Connective Tissue Diseases

Increased Epicardial Adipose Tissue Thickness Is Correlated with Ascending Aortic Diameter

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