2011
DOI: 10.1038/ajh.2010.111
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Association of Serum Uric Acid Level With Aortic Stiffness and Arterial Wave Reflections in Newly Diagnosed, Never-Treated Hypertension

Abstract: Serum UA levels are independently associated with aortic stiffening and wave reflections in never-treated hypertensives. Future studies are warranted in order to explore its exact role on arterial function in the hypertensive setting.

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Cited by 58 publications
(55 citation statements)
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“…Esen and coworkers proposed that UA is a marker of dilatation in the ascending aorta mediated by oxidative stress (Esen et al 2011). A significant association between serum UA levels, aortic stiffness and arterial wave reflections was demonstrated (Vlachopoulos et al 2011). Increased UA concentration has also been demonstrated in patients with coronary aneurysmal lesions (Sen et al 2009).…”
Section: Discussionmentioning
confidence: 95%
See 1 more Smart Citation
“…Esen and coworkers proposed that UA is a marker of dilatation in the ascending aorta mediated by oxidative stress (Esen et al 2011). A significant association between serum UA levels, aortic stiffness and arterial wave reflections was demonstrated (Vlachopoulos et al 2011). Increased UA concentration has also been demonstrated in patients with coronary aneurysmal lesions (Sen et al 2009).…”
Section: Discussionmentioning
confidence: 95%
“…Recent studies identified possible roles of uric acid (UA) induced oxidative stress and increased inflammatory status in the pathogenesis of AscAA (Medina et al 2010;Sen et al 2009;Esen et al 2011;Vlachopoulos et al 2011). We hypothesized that cardiac adipose tissue may be involved in ascending aortic dilatation due to local or systemic effects.…”
mentioning
confidence: 99%
“…PWV was measured non-invasively using a validated device (Complior, Artech Medical, Pantin, France). 1 Left ventricular mass index (LVMI) and relative wall thickness were assessed by echocardiography. M-mode imaging was used for wall-thickness measurements.…”
mentioning
confidence: 99%
“…In patients with hypertensive chronic kidney disease, uric acid level was associated with only AIx@75, but not with PWV [49]. However, in newly diagnosed and untreated hypertensive patients, uric acid level was associated with PWV but not with AIx [50,51]. This phenomenon was also observed in patients in the active phase of Adamantiades-Behçet's disease.…”
Section: Augmentation Index and Markers Of Arterial Stiffness In Ctdsmentioning
confidence: 58%