Uric acid levels, left ventricular mass and geometry in newly diagnosed, never treated hypertension

Xaplanteris, Panagiotis; Vlachopoulos, C.; Vyssoulis, Gregory P.; Terentes‐Printzios, Dimitrios; Alexopoulos, Nikolaos; Lazaros, George; Stefanadis, Christodoulos

doi:10.1038/jhh.2010.120

Cited by 8 publications

(10 citation statements)

References 12 publications

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“…Several such studies have been performed. [11][12][13][14][15] However, the results have not been consistent. Some studies reported a positive association only in males 14,15) and others reported such an association only in females.…”

Section: Eft Ventricular Hypertrophy (Lvh) Is An Independentmentioning

confidence: 48%

“…13) In some studies, 11,13,15) the enrolled subjects were only hypertensive while in others, 12,14) they were apparently healthy subjects. Nowadays, many subjects are taking antihypertensive medications.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies reported a positive association only in males 14,15) and others reported such an association only in females. 13) In some studies, 11,13,15) the enrolled subjects were only hypertensive while in others, 12,14) they were apparently healthy subjects. Nowadays, many subjects are taking antihypertensive medications.…”

Section: Eft Ventricular Hypertrophy (Lvh) Is An Independentmentioning

confidence: 99%

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Serum Uric Acid Is Associated With the Left Ventricular Mass Index in Males of a General Population

et al. 2014

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SummaryThe association of serum uric acid (UA) with left ventricular hypertrophy (LVH) remains controversial. We investigated this issue in a general population. Participants consisted of 1,943 subjects (774 males and 1,169 females) aged over 40 years, living in Tanushimaru (a Japanese cohort of the Seven Countries Study). Serum UA and other biochemistry parameters were determined by a standard analytical technique. All individuals underwent anthropometric measurements and 2-dimensional echocardiography. Because serum UA levels are much higher in males than in females, they were analyzed separately. When LV mass index (LVMI) levels were stratifi ed according to tertile as low (≤ 80 cm : n = 252) in males, there were signifi cant relationships between LVMI and UA, in addition to age, body mass index, systolic blood pressure, medication for hypertension, triglycerides, and alcohol intake. Multiple stepwise regression analysis revealed LVMI was signifi cantly associated with systolic BP (P < 0.0001), medication for hypertension (P < 0.0001), UA (P = 0.003), BMI (P = 0.019), and alcohol intake (P = 0.038) in males. In females, LVMI was not associated with UA. In a multiple logistic regression analysis, a signifi cantly higher odds ratio of LVH (odds ratio: 1.77, 95%CI: 1.01-3.09, P < 0.05) was observed for males in the highest UA tertile versus the lowest UA tertile after adjustments for confounding factors, but not for females. In this cross-sectional study, there was a clear difference in the relation of UA and LVH between males and females. High serum UA was signifi cantly and independently associated with LVH evaluated by echocardiography in only males of a general population. (Int Heart J 2014; 55: 65-70) Key words: Epidemiology, Echocardiography L eft ventricular hypertrophy (LVH) is an independent and powerful risk factor for cardiovascular events and death. 1,2) Uric acid (UA) may induce LVH and the following mechanisms have been proposed.3) UA induces infl ammatory and proliferative cytokines like tumor necrosis factor-α and mitogen-activated protein kinases, [4][5][6] which promote cardiac hypertrophy. UA also activates the renin-angiotensin-aldosterone system, 7-10) which is a well-known system for hypertrophy and hyperplasia of myocytes and fi brosis of the heart. Thus, it may be interesting to study in humans whether UA is associated with LVH. Several such studies have been performed.11-15) However, the results have not been consistent. Some studies reported a positive association only in males 14,15) and others reported such an association only in females.13) In some studies, 11,13,15) the enrolled subjects were only hypertensive while in others, 12,14) they were apparently healthy subjects. Nowadays, many subjects are taking antihypertensive medications. Thus, data must be analyzed after adjustment for confounders like gender, hypertension, and others. Furthermore, in many studies, 14,16) LVH was measured by electrocardiography (ECG), and in a few studies, 12,13) it was measured by echocardiograph...

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Section: Eft Ventricular Hypertrophy (Lvh) Is An Independentmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Section: Eft Ventricular Hypertrophy (Lvh) Is An Independentmentioning

confidence: 99%

See 1 more Smart Citation

Serum Uric Acid Is Associated With the Left Ventricular Mass Index in Males of a General Population

et al. 2014

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“…Finally, in 1225 newly diagnosed hypertensive patients, SUA was related to LVMI in univariate analysis [17]. However, this relationship became barely significant after adjustment for multiple confounders, not including, like in the previous study, BMI and systolic BP [17].…”

Section: Discussionmentioning

confidence: 68%

“…Moreover, Viazzi et al, in 425 middle-aged hypertensive subjects, in univariate analysis, found a correlation between SUA and LVMI, only in women, but the statistical significance was just on the borderline level(p Z 0.04) [16].In female gender, the probability of having LVH was higher in subjects with elevated SUA levels in multiple logistic regression analysis (p Z 0.03), but the multivariate model did not include relevant covariates, known to be associated with SUA or LVM, such as BMI and systolic BP [16]. Finally, in 1225 newly diagnosed hypertensive patients, SUA was related to LVMI in univariate analysis [17]. However, this relationship became barely significant after adjustment for multiple confounders, not including, like in the previous study, BMI and systolic BP [17].…”

Section: Discussionmentioning

confidence: 99%

Absence of an independent association between serum uric acid and left ventricular mass in Caucasian hypertensive women and men

Mulè

Nardi

Costanzo

et al. 2013

Nutrition, Metabolism and Cardiovascular Diseases

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Background and aim: Experimentally uric acid may induce cardiomyocyte growth and interstitial fibrosis of the heart. However, clinical studies exploring the relationship between serum uric acid (SUA) and left ventricular (LV) mass yielded conflicting results.The aim of our study was to evaluate the relationships between SUA and LV mass in a large group of Caucasian essential hypertensive subjects. Methods and results: We enrolled 534 hypertensive patients free of cardiovascular complications and without severe renal insufficiency. In all subjects routine blood chemistry, including SUA determination, echocardiographic examination and 24 h ambulatory blood pressure (BP) monitoring were obtained.In the overall population we observed no significant correlation of SUA with LV mass indexed for height 2.7 (LVMH 2.7 ) (r Z 0.074). When the same relationship was analysed separately in men and women, we found a statistically significant correlation in female gender (r Z 0.27; p < 0.001), but not in males (r Z À0.042; p Z NS). When we grouped the study population in sex-specific tertiles of SUA, an increase in LVMH 2.7 was observed in the highest tertiles in women (44.5 AE 15.6 vs 47.5 AE 16 vs 55.9 AE 22.2 g/m 2.7 ; p < 0.001), but not in men.The association between SUA and LVMH 2.7 in women lost statistical significance in multiple regression analyses, after adjustment for age, 24 h systolic BP, body mass index, serum creatinine and other potential confounders. Conclusions: Our findings do not support an independent association between SUA and LV mass in Caucasian men and women with arterial hypertension. ª

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Potential Underlying Mechanisms Explaining the Cardiorenal Benefits of Sodium–Glucose Cotransporter 2 Inhibitors

Verma,

Mudaliar,

Greasley

2023

Adv Ther

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Uric acid levels, left ventricular mass and geometry in newly diagnosed, never treated hypertension

Cited by 8 publications

References 12 publications

Serum Uric Acid Is Associated With the Left Ventricular Mass Index in Males of a General Population

Serum Uric Acid Is Associated With the Left Ventricular Mass Index in Males of a General Population

Absence of an independent association between serum uric acid and left ventricular mass in Caucasian hypertensive women and men

Potential Underlying Mechanisms Explaining the Cardiorenal Benefits of Sodium–Glucose Cotransporter 2 Inhibitors

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