Association of Serum Uric Acid Levels with Leg Ischemia in Patients with Peripheral Arterial Disease after Treatment

Sotoda, Yoko; Hirooka, Shigeki; Orita, Hiroyuki; Wakabayashi, Ichiro

doi:10.5551/jat.37010

Cited by 14 publications

(10 citation statements)

References 32 publications

(41 reference statements)

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“…Some studies found that in patients with hyperuricemia, the accumulation of uric acid and activation of xanthine oxidoreductase may induce inflammation and increase oxidative stress, accelerates atherosclerotic progression, and promote the progression of PAD. 13 In a study of 508 patients with T2DM, Tseng found uric acid levels were higher in patients with PAD than in those without, suggesting elevated uric acid level is a significant and independent risk factor for PAD in patients with T2DM. 9 In Tseng’s study, some patients were not elderly, while they obtained the same conclusion.…”

Section: Discussionmentioning

confidence: 98%

Risk factors for peripheral arterial disease in elderly patients with Type-2 diabetes mellitus: A clinical study

et al. 2020

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Objectives: To determine risk factors for peripheral arterial disease (PAD) in elderly patients with Type-2 diabetes mellitus. Methods: The elderly patients with Type-2 diabetes treated in the Central Hospital of Cangzhou were enrolled and divided into PAD group and non-PAD group between October 2016 and November 2019, The data of the patients including age, gender, body mass index, blood pressure, hemoglobin A1c, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, total cholesterol, triglyceride, white cell count, lymphocyte count, high-sensitivity C-reactive protein, uric acid as well as living habits and complications of Type-2 diabetes mellitus were recorded to determine the risk factors for PAD. Results: One thousand four hundred seventy six (1476) patients were enrolled, in which 465 patients were included in group of PAD, and 1011 in non-PAD group. The univariate analysis revealed that the two groups significantly differed in age (p=0.003), course of T2DM (p=0.001), hypertension (p=0.006), smoking habits (p<0.001), hyperuricemia (p<0.01), high-sensitivity C-reactive protein (p<0.01), white cell count (p<0.001), lymphocyte count (p<0.001) and diabetic neuropathy (p<0.001). In the multivariate analysis, age (OR: 1.56, 95% CI: 1.21-1.89), smoking habit (OR: 1.37, 95% CI: 1.19-1.68), hypertension (OR: 1.44, 95% CI: 1.15-1.98), diabetic neuropathy (OR: 3.55, 95% CI: 2.14-4.29), high-sensitivity C-reactive protein (OR: 1.74, 95% CI: 1.39-2.61) and hyperuricemia (OR: 2.71, 95% CI: 1.66-3.87) were significant risk factors for PAD. Conclusions: Age, smoking habit, hypertension, diabetic neuropathy, high-sensitivity C-reactive protein and hyperuricemia were independent risk factors for peripheral arterial disease in elderly patients with Type-2 diabetes mellitus. doi: https://doi.org/10.12669/pjms.36.6.2906 How to cite this:Shou Z, Zhao Y, Zhang Y, Li S. Risk factors for peripheral arterial disease in elderly patients with Type-2 diabetes mellitus: A clinical study. Pak J Med Sci. 2020;36(6):---------. doi: https://doi.org/10.12669/pjms.36.6.2906 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 98%

Risk factors for peripheral arterial disease in elderly patients with Type-2 diabetes mellitus: A clinical study

et al. 2020

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“…Uric acid is the final product of purine metabolism. In recent years, several population‐based studies have reported an association between serum uric acid (SUA) levels and increased risk of cardiovascular (CV) disorders such as hypertension, 1 myocardial infarction, 2 stroke, 3 peripheral arterial disease, 4 and sudden cardiac death 5,6 . Despite the fact that a continuous relationship between SUA and all‐cause and CV mortality has been suggested by many studies, more recently, data from the URRAH study (Uric Acid Right for Heart Health), allowed us to identify prognostic cut‐off values for major adverse events 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Serum uric acid levels and the risk of recurrent venous thromboembolism

Lucchi

Nardin

Sponchiado

et al. 2021

Journal of Thrombosis and Haemostasis

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Increase in serum uric acid (SUA) levels has been widely associated with higher risk of cardiovascular disease. We investigated the link between SUA levels and the risk of venous thromboembolism (VTE) recurrence. Patients with SUA levels ≥ 4.38 mg/dL showed a three‐fold increase in the risk of VTE recurrence. Elevated SUA levels are associated with increased risk of recurrent VTE independently from traditional risk factors. Abstract BackgroundThe link between serum uric acid (SUA) and the risk of cardiovascular disease is well established. However, the impact of SUA levels on the risk of venous thromboembolism (VTE) recurrence is unknown. ObjectivesTo investigate the association between SUA and the risk of VTE recurrence. Patients and MethodsWe performed a monocenter, prospective study on 280 patients with a previous episode of VTE that completed the oral anticoagulant period. SUA levels at enrollment were correlated with the risk of VTE recurrence (mean follow‐up 71.1 ± 29.2 months). ResultsPatients were stratified according to SUA tertiles distribution at baseline (tertiles cut‐off: I ≤ 4.37 mg/dL, II 4.38‐‐5.54 mg/dL, III ≥ 5.55 mg/dL). Fifty episodes of VTE recurrence occurred during the follow‐up and Kaplan‐Meier survival analysis showed that subjects in the lower tertile of SUA distribution had significantly lower risk of future VTE recurrence (P = .003). No differences were seen among patients belonging to the second and the third tertile of SUA distribution. A multivariate Cox regression analysis showed that higher tertiles of SUA distribution had about three‐fold increase in the risk of VTE recurrence as compared to subjects with SUA ≤ 4.37, independently from potential confounders (hazard ratio [HR] 3.04, 95% confidence interval [CI] 1.15‐‐8.05 P = .025). Moreover, we observed that the adjusted hazard of VTE recurrence increased by 30% for each additional unit of SUA (mg/dL; HR 1.30, 95% CI 1.01‐‐1.22, P = .040). ConclusionElevated SUA levels are associated with increased risk of future VTE recurrence independently from traditional risk factors.

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“… 25 Sotoda et al found that sUA levels are associated with the degree of leg ischemia in patients with peripheral arterial disease (PAD). 26 However, the gender differences in the association between sUA and arteriosclerotic cardiovascular risk among type 2 diabetes mellitus patients have been rarely studied.…”

Section: Discussionmentioning

confidence: 99%

Gender Differences in the Association Between Serum Uric Acid and Arteriosclerotic Cardiovascular Risk Among Chinese Type 2 Diabetes Mellitus Patients

Yang¹,

Gao²,

Li³

et al. 2021

IJGM

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Background and Objectives: Serum uric acid (sUA) level has been reported to be associated with arteriosclerotic cardiovascular risk, yet remains poorly defined in Chinese type 2 diabetes patients. The purpose of the current study was to evaluate gender differences in the association between sUA level and arteriosclerotic cardiovascular risk in Chinese type 2 diabetes patients. Methods: The cross-sectional study was conducted in six community health service centers in Shanghai, China from December 2014 to December 2016. A stratified random sampling method was used to recruit participants. From a total of 3977 type 2 diabetic patients, 2537 were included for the analysis of the association between sUA level and arteriosclerotic cardiovascular risk. Clinical and biochemical data were obtained from participants. Arteriosclerotic cardiovascular risk was evaluated by the ten-year risk profile for arteriosclerotic cardiovascular disease. The associations between sUA level and arteriosclerotic cardiovascular risk were assessed via multiple logistic regression. Results: Of the 2537 participants, the average sUA level was 317±77umol/L in men and 294±73 umol/L in women, and 54.8% (1391/2537) of participants had high tenyear risk of arteriosclerotic cardiovascular disease (ASCVD), which was ≥20%. High ten-year risk of ASCVD odds ratio was increased by 1.596 (95% CI, 1.113-2.289, p for trend 0.004) comparing fourth to first quartiles of sUA in women. However, no significant association was found between sUA and high ten-year risk of ASCVD in men. Conclusion:This community-based study indicated that sUA levels were independently associated with high ten-year risk of ASCVD in women with type 2 diabetes mellitus, but not in men.

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Association of Serum Uric Acid Levels with Leg Ischemia in Patients with Peripheral Arterial Disease after Treatment

Cited by 14 publications

References 32 publications

Risk factors for peripheral arterial disease in elderly patients with Type-2 diabetes mellitus: A clinical study

Risk factors for peripheral arterial disease in elderly patients with Type-2 diabetes mellitus: A clinical study

Serum uric acid levels and the risk of recurrent venous thromboembolism

Gender Differences in the Association Between Serum Uric Acid and Arteriosclerotic Cardiovascular Risk Among Chinese Type 2 Diabetes Mellitus Patients

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