Association of serum uric acid with bone mineral density and clinical fractures in Chinese type 2 diabetes mellitus patients: A cross-sectional study

Yan, Pingping; Zhang, Zhihong; Wan, Qin; Zhu, Jianhua; Li, Hua; Gao, Chenlin; Ma, Huan; Xu, Yong

doi:10.1016/j.cca.2018.07.033

Cited by 23 publications

(44 citation statements)

References 55 publications

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“…Therefore, it remains unclear whether or not serum UA is involved in the fracture risk in T2DM. Yan et al previously reported that serum UA was not associated with BMD-independent risk of self-reported clinical fractures although serum UA was inversely associated with clinical fracture risk in Chinese population with T2DM [23]. In contrast, in the present study, the serum UA level was positively associated with the presence of VF in logistic regression analyses adjusted for LS-BMD and FN-BMD.…”

Section: Discussioncontrasting

confidence: 84%

“…Previous studies showed that serum UA level was positively associated with BMD in patients with T2DM [23,24]. In this study, simple correlation analysis showed that serum UA level was positively correlated with LS-BMD and negatively with uNTX in both women and men, and multiple regression analysis showed that serum UA level was marginally and positively associated with LS-BMD in women.…”

Section: Discussionsupporting

confidence: 57%

“…Majumdar et al reported that patients with T2DM loner than 10 years are at particularly high risk of fracture [33]. Mean diabetic duration of the subjects in the previous study by Yan et al was 7.41 years and 8.53 years in men and postmenopausal women, respectively [23], while that of our patients was 12.6 years and 12.2 years in men and post-menopausal women, respectively. Therefore, methodology to collect fragility fracture and fracture site as well as background such as duration of diabetes might be related to the contrasting findings between the previous study and ours.…”

Section: Discussioncontrasting

confidence: 46%

“…Therefore, the roles of UA in bone metabolism should be investigated in diabetesinduced bone fragility. A couple of cross-sectional studies showed that serum UA levels were positively associated with BMD in patients with T2DM [23,24]. However, Yan et al reported that serum UA was not associated with the presence of clinical fracture although the association was significant before adjusting for BMD [23].…”

Section: Introductionmentioning

confidence: 99%

“…A couple of cross-sectional studies showed that serum UA levels were positively associated with BMD in patients with T2DM [23,24]. However, Yan et al reported that serum UA was not associated with the presence of clinical fracture although the association was significant before adjusting for BMD [23]. Therefore, it is still unclear whether or not serum UA is involved in fragility fracture risk in patients with T2DM.…”

Section: Introductionmentioning

confidence: 99%

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Higher Serum Uric Acid is a Risk Factor of Vertebral Fractures in Postmenopausal Women with Type 2 Diabetes Mellitus

Tanaka

Kanazawa

Notsu

et al. 2018

Exp Clin Endocrinol Diabetes

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Purpose Serum uric acid (UA) level may affect bone metabolism because it has an anti-oxidative effect. However, whether serum UA level is associated with a fracture risk in type 2 diabetes mellitus (T2DM) is unclear. We thus aimed to clarify the association between serum UA and bone parameters in T2DM. Methods We conducted a cross-sectional study to investigate the association of serum UA with bone mineral density (BMD) at lumbar spine (LS) and femoral neck (FN), bone turnover markers such as osteocalcin and urine type I collagen cross-linked N-telopeptide (uNTX), and the prevalence of vertebral fractures (VF) in 356 postmenopausal women and 512 men with T2DM. Results Multiple regression analyses adjusted for age, duration of diabetes, hemoglobin A1c, body mass index and log (serum creatinine) showed that serum UA level was significantly and negatively associated with uNTX in postmenopausal women with T2DM, whereas it was not associated with osteocalcin or BMD at each site. In men, serum UA was not associated with BMD or bone turnover markers. Because postmenopausal women with VF were significantly older and had longer duration of diabetes, higher serum creatinine level and lower BMD than those without it, logistic regression analyses adjusted for these confounding factors were performed. Higher serum UA level was significantly associated with the presence of VF. Conclusions The present study showed that higher serum UA is a risk factor for VF independently of BMD in postmenopausal women with T2DM.

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Section: Discussioncontrasting

confidence: 84%

Section: Discussionsupporting

confidence: 57%