Association of serum resistin levels with metabolic syndrome and early atherosclerosis in obese Chinese children

Chen, Xiaoyi; Zhang, Jinhua; Liu, Feng; Liu, Hongmei; Song, Yiyan; Liu, Yunling

doi:10.1515/jpem-2012-0326

Cited by 9 publications

(6 citation statements)

References 6 publications

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“…Authors have shown that resistin controls the proinflammatory cytokine cascade [2,17] and that increased visfatin concentration was related to inflammation in overweight individuals [40,44,49]. Such inflammatory signaling significantly alters lipid metabolism in adipose tissue, liver, and skeletal muscle, and the interaction between dyslipidemia and inflammation accelerates the development of atherosclerosis and insulin resistance [50,51].…”

Section: Discussionmentioning

confidence: 99%

Resistin and visfatin concentrations are related to central obesity and inflammation in Brazilian children

Simões

Domingos

Oliveira

et al. 2018

Nutrire

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Background: The evidence that cardiovascular disease begins in childhood and adolescence, especially in the presence of excess weight, is associated with dysfunction on adipokine pro-inflammatory secretion. These affect glucose metabolism and lead to other complications related to insulin resistance and cardiovascular disease. This study assessed the association of anthropometric and metabolic parameters related to obesity, cardiovascular risk, and insulin resistance with concentrations of resistin and visfatin, in children. Methods: A cross-sectional study was developed with 178 children of 6-10 years old enrolled in public city schools. Anthropometric data, composition body, clinical, and biochemical were measured according to standard procedures. We used multiple regression models by stepwise method to evaluate the associations of resistin and visfatin with variables of interest. Results: In healthy weight children, resistin was associated with LDL cholesterol, visfatin, atherogenic index, and waist-to-height ratio, whereas in obese children resistin was associated with visfatin and interaction between conicity index and HOMA-AD. Furthermore, in healthy weight children, visfatin was associated to resistin and triceps skinfold thickness and negatively associated to HOMA-AD, while in obese ones visfatin was associated with waistto-height ratio, atherogenic index, resistin, and interaction between trunk adiposity index and adiponectin and was negatively associated with the HOMA-IR index. Conclusions: Our study shows an association between anthropometric and biochemical variables related to visceral fat and inflammation. These results suggest the resistin and visfatin as good pro-inflammatory markers. In addition, both adipokines are strongly related to central obesity, in children.

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Section: Discussionmentioning

confidence: 99%

Resistin and visfatin concentrations are related to central obesity and inflammation in Brazilian children

Simões

Domingos

Oliveira

et al. 2018

Nutrire

View full text Add to dashboard Cite

show abstract

“…Moreover, genetic studies showed that two single nucleotide polymorphisms (SNPs: −537A > C and −420C > G) were associated with increased resistin levels in diabetic patients, but not in control subjects [ 75 ]. Recently, associations have been reported between resistin and metabolic syndrome components on one hand and early atherosclerosis in obese children on the other hand [ 76 ]. Finally, resistin has been demonstrated to stimulate the secretion of several inflammatory factors (e.g., TNF- α , IL-6, IL-8, and MCP-1) known to play a role in the induction of insulin resistance [ 77 ].…”

Section: Adipose Tissue Inflammation Is Crucial In the Developmentmentioning

confidence: 99%

Adipose Tissue in Obesity-Related Inflammation and Insulin Resistance: Cells, Cytokines, and Chemokines

2013

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Adipose tissue is a complex organ that comprises a wide range of cell types with diverse energy storage, metabolic regulation, and neuroendocrine and immune functions. Because it contains various immune cells, either adaptive (B and T lymphocytes; such as regulatory T cells) or innate (mostly macrophages and, more recently identified, myeloid-derived suppressor cells), the adipose tissue is now considered as a bona fide immune organ, at the cross-road between metabolism and immunity. Adipose tissue disorders, such as those encountered in obesity and lipodystrophy, cause alterations to adipose tissue distribution and function with broad effects on cytokine, chemokine, and hormone expression, on lipid storage, and on the composition of adipose-resident immune cell populations. The resulting changes appear to induce profound consequences for basal systemic inflammation and insulin sensitivity. The purpose of this review is to synthesize the current literature on adipose cell composition remodeling in obesity, which shows how adipose-resident immune cells regulate inflammation and insulin resistance—notably through cytokine and chemokine secretion—and highlights major research questions in the field.

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“…Although these characteristics make resistin a good biomarker of atherosclerosis, its relationship with IMT—a marker of initial asymptomatic atherosclerosis—has been reported only in obese children [ 73 ] but there is no evidence of this association in obese adults [ 74 ]. In contrast, in obese patients, resistin correlated with key components that correlate vascular risk parameters to the development of atherosclerosis: platelet number and volumes (MPV), serum and platelet P-selectin, fibrinogen, PAI-1 ag (plasminogen activator inhibitor-1 antigen), and PMPs (platelet-derived microparticles [ 16 , 46 , 74 ]).…”

Section: Adipokines As Biomarkers In Atherosclerotic Heart Diseasementioning

confidence: 99%

Usefulness of the Adipokines as Biomarkers of Ischemic Cardiac Dysfunction

2018

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Cardiovascular disease is the leading cause of death among both women and men, but there is still a great percentage of misdiagnosis and lack of clearly defined criteria. Advances in biomolecular science have proven the crucial role of inflammation and, more importantly, the role of adipokines in mediating all stages of coronary artery disease. It has also been suggested that regional fat deposits, more precisely from thoracic region, have a major influence on the development of coronary artery disease by creating a local proatherogenic environment. The immune system closely interacts with metabolic risk factors to initiate, promote, and further aggravate the atherosclerotic lesions on the arterial wall all with the “help” of adipokines. So nowadays, research extensively focuses on uncovering biomarkers that would provide an increased chance of detecting subclinical cardiac distress and also add a consistent value to current guideline-imposed risk criteria.

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Association of serum resistin levels with metabolic syndrome and early atherosclerosis in obese Chinese children

Abstract: Resistin not only play a certain role in the presence of MS, but also indirectly via insulin resistance and Hs-CRP to contribute to early atherosclerosis in obese children.

Cited by 9 publications

References 6 publications

Resistin and visfatin concentrations are related to central obesity and inflammation in Brazilian children

Resistin and visfatin concentrations are related to central obesity and inflammation in Brazilian children

Adipose Tissue in Obesity-Related Inflammation and Insulin Resistance: Cells, Cytokines, and Chemokines

Usefulness of the Adipokines as Biomarkers of Ischemic Cardiac Dysfunction

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