Association of serum osteoprotegerin with severity of chronic liver disease in female patients: A potential biomarker

Tariq, Saba; Tariq, Sundus; Hussain, Shaista; Baig, Mukhtiar

doi:10.12669/pjms.36.6.2678

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…Our results were similar to some other studies conducted in [8,13] Hepatitis C patients . Hepatitis affects liver & alter various glycoproteins levels which can result in different pathophysiological process [1,16] harmful for the body . It is very important to treat Hepatitis C virus infection with effective treatment without causing serious health problem.…”

Section: Resultsmentioning

confidence: 99%

Effectiveness and Safety of Sofosbuvir and Velpatasvir in Hemodialysis Patients Suffering With Hepatitis C Infection

Mehmood¹,

Ashraf²,

Mastoor³

et al. 2021

JUMDC

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BACKGROUND & OBJECTIVE: There is scantiness of evidence-based knowledge of anti-viral therapy with sofosbuvir (SOF) and velpatasvir (VLP) in patients on maintenance haemodialysis. This report is an attempt to rationalise the safety and effectiveness of SOF and VLP in haemodialysis patients in Pakistan. METHODOLOGY: Twenty treatment-naïve patients were incorporated in this study. Patients on maintenance haemodialysis are being administered SOF and VLP. Before initiation of treatment, all necessary investigations such as viral load, liver fibro scan, genotyping and upper GI endoscopy were made. Patients received 400 mg/day and 100 mg/day dose of SOF and VLP, respectively. RESULTS: Mean age was 25 to 53 years; 30% were male and 70% were female as categorized. No one of these has clinical affirmation of progression of cirrhosis. The most prevalent genotype was genotype 4 that was found in 45% of cases and the second most evident was genotype 1 in 25% of cases and genotype 5 in 30% of cases. Time span of antiviral therapy was 12 weeks. CONCLUSION: SOF and VLP based direct antiviral agents were effectual, puissant and were aptly tolerated in patients on MHD. This drug combination was well tolerated in haemodialysis patients. Not a single patient discontinued this combination therapy due to severe complications.

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Section: Resultsmentioning

confidence: 99%

Effectiveness and Safety of Sofosbuvir and Velpatasvir in Hemodialysis Patients Suffering With Hepatitis C Infection

Mehmood¹,

Ashraf²,

Mastoor³

et al. 2021

JUMDC

View full text Add to dashboard Cite

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“…(5) Moreover, OPG has been demonstrated to function as a survival factor in various cell types. (6) This action is caused by the binding of the TNF-related apoptosis-inducing ligand (TRAIL), inhibiting the apoptosis process in sensitive cells. (7) On the contrary, inhibiting the association between RANK:RANKL on dendritic cells (DCs) and activated T-cells is another function of OPG in immune regulation.…”

Section: Introductionmentioning

confidence: 99%

Osteoprotegerin and Interleukin-37 are Correlated with Liver Diseases in Chronic Hepatitis B Virus (HBV)-infected Subjects

Alsalimi,

Al-Mashkor,

Al-Fartosy

2023

Indones Biomed J

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BACKGROUND: Various biological markers have been proposed to predict subclinical events in subjects with chronic hepatitis B virus (HBV). However, studies regarding chronic HBV infection are still limited. The current study aimed to investigate the relationship between osteoprotegerin (OPG) and interleukin-37 (IL-37) serum levels in chronic HBV subjects.METHODS: Sixty subjects with chronic HBV infection without previous treatment and 30 healthy subjects were included in this study. Blood samples were withdrawn and examined for biochemical parameters through the use of enzyme-linked immunosorbent assay (ELISA) assessments. Moreover, anthropometric estimations and medical histories were performed on all subjects through a standard self-administered questionnaire.RESULTS: A highly significant elevation (p<0.01) in serum levels of alanine transaminase (ALT), aspartate transaminase (AST), and IL-37 and a significant increase (p<0.05) in serum level of OPG were observed in chronic HBV subjects compared with the controls. The data demonstrated that OPG had a positive correlation with IL-37 and that both OPG and IL-37 had significantly positive correlations with ALT and AST. Furthermore, the area under the receiver operating characteristics (ROC) curve (AUC) was computed for ALT, AST, OPG, and IL-37 (AUC = 0.831, 0.829, 0.608, and 0.618, respectively) which could be potentially greater predictive biomarkers in chronic HBV subjects.CONCLUSION: The positive correlation of OPG and IL-37 with ALT and AST and the high positive value of AUC for OPG and IL-37 shows that OPG and IL-37 could to be potential inflammatory biomarkers for the early onset of liver disease and hepatocellular carcinoma in chronic HBV-infected subjects.KEYWORDS: osteoprotegerin, interleukin-37, hepatitis B virus, inflammation, liver

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Association of serum osteoprotegerin with severity of chronic liver disease in female patients: A potential biomarker

Cited by 2 publications

References 23 publications

Effectiveness and Safety of Sofosbuvir and Velpatasvir in Hemodialysis Patients Suffering With Hepatitis C Infection

Effectiveness and Safety of Sofosbuvir and Velpatasvir in Hemodialysis Patients Suffering With Hepatitis C Infection

Osteoprotegerin and Interleukin-37 are Correlated with Liver Diseases in Chronic Hepatitis B Virus (HBV)-infected Subjects

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