Association of serum omentin-1 concentrations with the presence and severity of preeclampsia

Abstract

Background: Inflammation is involved in the pathogenesis of preeclampsia. Omentin is a newly discovered adipokine that possesses an anti-inflammatory function. The aim of this study was to determine the association of serum omentin-1 concentration with the presence and severity of preeclampsia. Methods: Serum concentrations of omentin-1 were measured in 128 women with preeclampsia and 96 women with uncomplicated pregnancies using an enzyme-linked immunosorbent assay method. Results: Patients with preeclampsia had significantly lower serum concentrations of omentin-1 compared to healthy controls. In addition, those patients with severe preeclampsia had significantly lower concentrations of serum omentin-1 compared to those with mild preeclampsia. Simple linear regression analysis showed that in patients with preeclampsia the serum concentrations of omentin-1 showed significant correlation with body mass index (P < 0.001), systolic blood pressure (P < 0.05) and homeostasis model assessment of insulin resistance (P < 0.001). Conclusion: Decreased concentrations of serum omentin-1 appear to be associated with the presence and severity of preeclampsia.

Association between insulin resistance and preeclampsia in obese non-diabetic women receiving metformin

“…Some studies reported that in women who develop preeclampsia maternal HOMA-IR is increased and this increase precedes the clinical onset of the disease and it may be apparent from the first trimester of pregnancy. 7–12 However, several other studies found no significant differences in HOMA-IR between preeclamptic and non-preeclamptic groups in the first, second or third trimesters of pregnancy or at the time of delivery. 13–19…”

“…Some studies reported that in women who develop preeclampsia maternal HOMA-IR is increased and this increase precedes the clinical onset of the disease and it may be apparent from the first trimester of pregnancy. [7][8][9][10][11][12] However, several other studies found no significant differences in HOMA-IR between preeclamptic and non-preeclamptic groups in the first, second or third trimesters of pregnancy or at the time of delivery. [13][14][15][16][17][18][19] Preeclampsia has a complex pathophysiology and the primary cause is thought to be impaired placentation leading to placental hypoxia and oxidative stress with consequent release of anti-angiogenic factors, such as soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG), into the maternal circulation, which in turn lead to endothelial dysfunction and multisystem organ injury.…”

Relationship between vitamin D and gestational diabetes in overweight or obese pregnant women may be mediated by adiponectin

“…We report that 25(OH)D concentrations were positively associated with HMW‐adiponectin, but not with IL‐6, MCP‐1, omentin‐1, or visfatin after adjustment for maternal factors. Inflammation and adipose tissue failure (characterized by altered adipokine concentrations), have been implicated in the pathophysiology of GDM , PTB , and preeclampsia . Studies show that omentin‐1 has insulin‐sensitizing effects , while visfatin activates the insulin receptor and MCP‐1 deficiency ameliorates insulin resistance .…”

Adiponectin and Omentin Levels as Predictive Biomarkers of Preterm Birth in Patients with Gestational Diabetes Mellitus

“…Several publications describing omentin in association with pregnancy have been published [ 37 – 39 ]. However, we have found only one article analyzing omentin-1 in relation to preterm birth.…”