Association of serum level of 25-hydroxy vitamin D with Oral Lichen Planus. A case-control study.

Abstract

Introduction: Vitamin D deficiency is a global health problem that can be a risk factor for a broad range of diseases such as some autoimmune diseases. Due to the autoimmune base of lichen planus, it seems that a reduction of the serum level of vitamin D is related to lichen planus. In this study, we investigate the relation between serum level of vitamin D and oral lichen planus patients (OLP). Material and Methods: In this case-control study, 35 patients with OLP (including 15 men and 20 women) and 70 healthy volunteers (including 35 men and 35 women), aged between 30-60 years old, referred to Qazvin University of Medical Sciences were investigated. None of these volunteers had systemic diseases. Vitamin D levels were measured with ELFA (Enzyme Linked Fluorescent Assay) and the data was analyzed using the chi-squared test and t-test. Results: The mean serum level of vitamin D in the control group was 23.7±9ng/ml and in the case group was 18.12±8/7ng/ml. The results show that the serum level of vitamin D in patients with OLP is significantly less than in the control group (p<0.05). Conclusion: According to the results, the serum level of vitamin D in patients with OLP was significantly lower than that of healthy people.

Serum Concentration of Vitamin D in Patients with Oral Lichen Planus

“…The T-test results showed a statistically significantly lower serum vitamin D concentration in the OLP group compared to the control group (p=0.001). These results confirm the study of Sadeghi et al, who found a statistically significantly lower vitamin D serum concentration in OLP patients ( 9 ). On the other side, the research by Bahramian et al ( 10 ) and the systematic review and meta-analysis by Sakthivel et al ( 11 ) found no statistically significant difference in serum vitamin D concentration between the OLP patients and the control group.…”

“…Vitamin D may play a role in the development or severity of the clinical picture of symptomatic forms of OLP by regulating immune system function ( 9 ). Active forms of vitamin D have a regulatory role in the expression of several genes.…”

“…It also leads to significant inflammation in immune-mediated diseases such as OLP. Therefore, it is essential to investigate serum vitamin D levels in the population, especially in chronic inflammatory autoimmune diseases such as OLP ( 9 ).…”

“…It is widely accepted in the scientific community that 25-(OH) D3 concentrations ranging between 75 and 150 nmol/L are desirable, and that concentrations below 50 nmol/L are inadequate for musculoskeletal health ( 9 ). However, in the OLP group, only two patients had adequate serum vitamin D concentrations (5.88%), whereas eight participants had adequate serum vitamin D concentrations in the control group (23.53%).…”

Relación entre la Vitamina D y el Liquen Plano Oral. Revisión Sistemática Exploratoria

“…Existe amplia evidencia que bajos niveles séricos de VD se relacionan con una respuesta inflamatoria exagerada, presente en diversas patologías de carácter autoinmune, por lo que, recientemente investigaciones han buscado cuantificar la concentración sérica de VD en pacientes con LPO (Bahramian et al, 2018;Sadeghi et al, 2020). Los autores concluyeron que los niveles plasmáticos de VD en pacientes que padecían LPO son significativamente menores que los pacientes del grupo control (Bahramian et al, 2018;Sadeghi et al, 2020;Motahari et al, 2020;Sridharan & Sivaramakrishnan, 2021). También relatan la asociación entre liquen plano y el desarrollo de lesiones orales potencialmente malignas en algunos casos, por lo que la VD y su rol inmunomodulador e inflamatorio deben ser analizadas para prevenir esta enfermedad.…”