Association of Serum Heavy Metals and Trace Element Concentrations with Reproductive Hormone Levels and Polycystic Ovary Syndrome in a Chinese Population

Zheng, Guanchao; Wang, Lijun; Guo, Zhizhun; Sun, Lingbin; Wang, Lingling; Wang, Chonggang; Zuo, Zhenghong; Qiu, Huiling

doi:10.1007/s12011-015-0294-7

Cited by 72 publications

(81 citation statements)

References 37 publications

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“…Therefore, zinc deficiency may have a role as either an initiator or promoter of the underlying mechanisms and metabolic features of PCOS by means of causing insulin resistance, decreasing antioxidant capacity and inducing apoptosis. Moreover, it is possible that decreased antioxidant capacity can be aggravated by zinc deficiency and insulin resistance in women with PCOS [27].…”

Section: Discussionmentioning

confidence: 99%

Increased oxidative stress is associated with insulin resistance and infertility in polycystic ovary syndrome

et al. 2016

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Objectives: The present study aims to investigate the role of oxidant-antioxidant status in young women with polycystic ovary syndrome (PCOS). Material and methods:Seventy-one women with PCOS and 53 healthy controls are compared in aspect of demographic characteristics, biochemical data, hormones, and oxidant-antioxidant status. Results:The PCOS group had significantly lower zinc, higher malondialdehyde and gluthathione peroxidase and lower serum catalase levels than the control group (p = 0.016, p < 0.001, p = 0.043 and p = 0.025 respectively). The PCOS patients with IR had significantly higher malondialdehyde, lower catalase and serum zinc levels than the PCOS patients without IR (p = 0.015, p = 0.010, p = 0.001 respectively). The infertile PCOS patients had significantly higher malondialdehyde, lower catalase and serum zinc levels than the fertile PCOS patients Conclusions:The patients with PCOS are under oxidative stress and this oxidative stress seems to be the highest in patients with IR and with infertility. Despite the prominent increase in the oxidative stress, there was a variation in the antioxidant response.

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Section: Discussionmentioning

confidence: 99%

Increased oxidative stress is associated with insulin resistance and infertility in polycystic ovary syndrome

et al. 2016

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“…Of those, two were excluded after full text review because they did not focus on the serum levels of trace elements [40,41]. The six articles [42][43][44][45][46][47] that were included in the systematic review presented data on serum or plasma levels of chromium, cobalt, copper, manganese, nickel, selenium, vanadium, and zinc.…”

Section: Discussionmentioning

confidence: 99%

“…Table 1 describes the characteristics of the six studies included in the systematic review. One study focused on a Chinese population [42], another study on women from India [46], and four on Turkish women [43][44][45]47]. All were casecontrol studies and used the 2003 Rotterdam criteria [2] to diagnose PCOS.…”

Section: Study Selectionmentioning

confidence: 99%

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Blood Trace Element Concentrations in Polycystic Ovary Syndrome: Systematic Review and Meta-analysis

Spritzer

Lecke

Fabris

et al. 2016

Biol Trace Elem Res

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Polycystic ovary syndrome (PCOS) is a prevalent condition in women of reproductive age. PCOS is characterized by androgen excess and chronic anovulation and associated with low-grade inflammation and metabolic comorbidities. Some trace elements have been linked to pathophysiological mechanisms of oxidative stress and inflammation in different disorders. Therefore, we conducted a systematic review and meta-analysis of the available evidence regarding trace element concentrations in PCOS. We reviewed MEDLINE and EMBASE in search of case-control, cross-sectional, and cohort studies published until September 2015. Of 183 studies identified, six were selected for systematic review. All used the Rotterdam criteria for the diagnosis of PCOS. Two studies evaluating chromium and one assessing cobalt levels did not observe differences between PCOS and controls. Another study recorded similar nickel and vanadium levels between the groups, but lower selenium concentrations in women with PCOS compared to controls. Four studies were included in the random effects model meta-analysis, for a total of 264 PCOS and 151 control women. Copper levels were found to be higher in women with PCOS than in controls [mean difference 0.12 ppm (95 % CI 0.07; 0.17 ppm); I 2 = 0 %]. Manganese [mean difference 0.04 ppm (95 % CI −0.05; 0.13 ppm); I 2 = 94.4 %] and zinc concentrations [mean difference 0.02 ppm (95 % CI −0.12; 0.16 ppm); I 2 = 92.4 %] were similar between the groups. The present results suggest a relationship between increased copper concentration and PCOS. This systematic review and meta-analysis is registered in PROSPERO under number CRD42016034036.

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“…As well our results agree with Line ,et al who explained the elevated lead level observed in some rural areas by the fact that some villages are polluted with high concentration of lead in soil and household dust that subsequently carry lead exposure to the population there causing elevated lead level [18] [19] [20]. Air polluted by oxides and minerals more dangerous on human health where through breathing pollutants move by one hundred percent to human blood and features Baghdad city like all cities abundance cars which use fuel have dangerous toxic which include lead which effects significantly on the patients , elderly and pregnant women posing a risk to fetuses ,High lead level in the blood causes anemia and lakes of hemoglobin in the blood this may lead to liver kidney and brain damage and it was up to the central nervous system [21].…”

Section: Resultsmentioning

confidence: 99%

Lead Level in Pregnant Women Suffering from Pre- Ec-lampsia in Baghdad City- Iraq

Al-Shammery

2018

MJS

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This study was conducted on the number of pregnant women suffering from symptoms of preeclampsia who live in different areas in Baghdad city. These areas were suffering from air pollution by different pollutants in high rates and it was chosen from among these pollutants lead metal which is a high percentage of air pollution where it was observed by measuring the level of lead in blood serum which taken from pregnant women by 40 pregnant women suffering from symptoms of preeclampsia and 20 pregnant women don't suffering from any abnormal symptoms during pregnancy period and classified as control group , so we found marked a significant rise in lead level in comparison with control group reaching ratio of lead in blood of pregnant women which suffering from symptoms of preeclampsia 38.44 mg/dl ± 3.0 mg/dl in comparison with control group which 14.56 mg/d l± 2.50 mg/dl,this increase may refer to the amount of lead which found in the air and in excess of the normal limit which exposed pregnant women like all people through the overcrowding of roads and use fuel non-environmentally friendly through breathing which effect on pregnant women health, it has been shown on symptoms of preeclampsia from measuring systolic and diastolic blood pressure and measuring of urea in blood, T-test was used at possibility of(0.001)to see the difference between infected samples and control group, therefore this study suggested that a lead is one of the causes of preeclampsia because live in polluted and unhealthy environment.

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Association of Serum Heavy Metals and Trace Element Concentrations with Reproductive Hormone Levels and Polycystic Ovary Syndrome in a Chinese Population

Cited by 72 publications

References 37 publications

Increased oxidative stress is associated with insulin resistance and infertility in polycystic ovary syndrome

Increased oxidative stress is associated with insulin resistance and infertility in polycystic ovary syndrome

Blood Trace Element Concentrations in Polycystic Ovary Syndrome: Systematic Review and Meta-analysis

Lead Level in Pregnant Women Suffering from Pre- Ec-lampsia in Baghdad City- Iraq

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