Association of serum copper, zinc and selenium levels with risk of metabolic syndrome: A nested case-control study of middle-aged and older Chinese adults

Fang, Chen-Chen; Wu, Wenjun; Gu, Xuejiang; Dai, Shanshan; Zhou, Qi; Deng, Huihui; Shen, Feixia; Chen, Junjie

doi:10.1016/j.jtemb.2018.12.017

Cited by 33 publications

(25 citation statements)

References 44 publications

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“…Consistent with our findings that higher selenium was associated with higher odds of 7 Oxidative Medicine and Cellular Longevity hypertriglyceridemia and lower odds of low HDL-C, a recent study also revealed positive associations of selenium with triglyceride and HDL-C [27]. However, our findings that the inverse association between selenium and low HDL-C was significantly stronger in men than in women was contrary to a previous study that revealed that selenium was inversely related with HDL-C only in women [28]. The disagreement might be partly attributed to different study designs and population characteristics.…”

Section: Discussioncontrasting

confidence: 97%

Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene Polymorphism with Metabolic Syndrome and Its Components

Zhou

Luo

Yin

et al. 2020

Oxidative Medicine and Cellular Longevity

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The relationship between selenium and metabolic syndrome (MetS) has been discussed controversially, and limited studies have examined the associations of single nucleotide polymorphisms in selenoproteins genes with MetS. Hence, to examine the associations of plasma selenium concentrations and selenoprotein P rs7579 polymorphism with MetS, a case-control study of 1279 MetS cases and 1279 sex- and age- (±2 years) matched controls was conducted based on the baseline data of the Tongji-Ezhou Cohort study. Plasma selenium concentrations were measured by inductively coupled plasma mass spectrometry. MetS was defined using the definition of the Joint Interim Statement, adjusted for the Chinese population. In addition, the rs7579 polymorphism was genotyped by the Agena MassARRAY System. Plasma selenium concentrations in the MetS group were higher than in the control group (93.88 μg/L (83.17-107.41) vs. 92.66 μg/L (82.36-103.53), P<0.05). Compared with quartile 4 (≥103.53 μg/L), the multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) associated with MetS were 0.79 (0.59-1.06) for quartile 1 (<82.36 μg/L), 0.75 (0.56-1.01) for quartile 2 (82.37-92.66 μg/L), and 0.61 (0.45-0.83) for quartile 3 (92.67-103.52 μg/L). The cubic spline analyses revealed a U-shaped association between plasma selenium and MetS, with the lowest risk at around 93.69 μg/L. Moreover, in cubic spline analyses, plasma selenium showed U-shaped associations with central obesity and high blood pressure, positive associations with hypertriglyceridemia and hyperglycemia, and a negative association with low high-density lipoprotein cholesterol. Additionally, both the GA and GA+AA genotype carriers were associated with increased ORs of MetS comparing with the GG genotype carriers. Our findings suggested a U-shaped association between plasma selenium and MetS and diverse associations between plasma selenium and components of MetS. Furthermore, our study found that the A allele of rs7579 was associated with higher odds of MetS. Further studies are needed to confirm our findings and elucidate the underlying mechanisms.

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Section: Discussioncontrasting

confidence: 97%

Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene Polymorphism with Metabolic Syndrome and Its Components

Zhou

Luo

Yin

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…They believed that nutritional Se has anti-inflammatory potential, which can be effective in MetS patients [ 12 ]. In contrary, some studies have reported the impact of increased serum level of Se on MetS enhancement [ 43 ]. Ford et al conducted a cross-sectional study in 2003 in the US and evaluated the antioxidant conditions among MetS patients.…”

Section: Discussionmentioning

confidence: 99%

“…In conformity with the present study, Freitas et al observed lower nutritional intake of Zn in people with MetS when compared with healthy subjects [ 50 ]. In contrary, Fang and colleagues observed no relationship between the serum level of Zn and MetS and its components [ 43 ]. In the present study, it was revealed that the dietary intake of Zn was lower in the PCOS patients with MetS.…”

Section: Discussionmentioning

confidence: 99%

Comparison of dietary micronutrient intake in PCOS patients with and without metabolic syndrome

et al. 2021

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Background Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in reproductive-age women. It is one of the risk factors of metabolic syndrome (MetS). These two syndromes have an inflammatory etiologic foundation along with oxidative stress. The present study aimed to compare the dietary intake of antioxidant micronutrients in PCOS women with and without MetS. Materials and methods Overall, 42 participants eligible for this nested case control study were selected by the convenience sampling method. The case group included 14 PCOS patients with MetS and the control group included 28 PCOS patients without MetS. The dietary intake assessment of selenium, chromium, zinc, carotenoids, vitamin D and vitamin E was carried out by a 147-item Food Frequency Questionnaire (FFQ). PCOS and MetS were diagnosed using the Rotterdam criteria and NCEP ATP III, respectively. Statistical analysis was performed using SPSS16 software, T-test and Mann Whitney. Significant P-value was considered 0.05. Results Dietary intake of antioxidant micronutrients (selenium, zinc, chromium, carotenoids and vitamin E) was significantly lower in the PCOS women with MetS than in the control group (P < 0.05). Conclusion Since the PCOS patients without MetS had more intake of the aforementioned micronutrients than those with MetS, it is assumed that the dietary intake of these nutrients could probably have a protective effect on MetS.

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“…Анализ работ отечественных и зарубежных ученых, выполненных на клеточном, тканевом и организменном уровнях, а также клинико-биохимические наблюдения неопровержимо указывают на то, что имеющие место сдвиги в обмене биоэлементов при атеросклерозе, нарушениях углеводного и липидного обменов, некоторых эндокринных и сердечно-сосудистых заболеваниях являются звеньями патогенеза данных состояний [5]. Согласно немногочисленным данным литературы, при метаболическом синдроме (МС) также выявлены нарушения в микроэлементном статусе организма [7]. В связи с этим наряду с исследованием классических факторов риска сердечно-сосудистой патологии в последние годы учеными все чаще рассматривается роль МЭ и МК как одного из возможных механизмов развития МС и сердечно-сосудистых заболеваний [8].…”

Section: ââåäåíèåunclassified

“…Особый интерес вызывает наличие отрицательной корреляционной связи между уровнем Zn и показателем ОТ. В литературе имеются немногочисленные исследования, подтверждающие снижение уровня Zn у больных с ожирением [7]. Авторы объясняют это повышенной продукцией кортизола и адипоцитокинов в условиях избыточного накопления жировой ткани, что приводит к экспрессии цинкового транспортера ZipM и связанного с ним Zn и способствует снижению содержания последнего в плазме крови.…”

Section: îáñóAeäåíèåunclassified

Abnormal values of trace elements and blood metals in patients with metabolic syndrome, depending on its components

Подзолков

Иванович²,

Korolyova

et al. 2019

Terapevticheskii arkhiv

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Aim. To study the level of “toxic” (Al, Cd, Pb) and “essential” (Fe, Cu, Zn, Co, Cr, Ni, and Se) trace elements (TE) and blood metals (BM) in patients with metabolic syndrome (MS), depending on its individual components. Materials and methods. 112 patients with MS were examined (45 men and 67 women; average age 61.4±7.2 years, average duration of MS 8.7±5.2 years). The study of BM was carried out by atomic emission spectrophotometry with inductively coupled plasma . Results and discussion. To study the amount of TE and BM in the group of MS patients,it was significantly higher levels of “toxic” MEs - Al, Cd, Pb - were revealed along with a decrease in the content of the “essential” Zn element as compared to the control group. At the same time, a pronounced positive correlation between the fact of the presence of MS and the level of “toxic” microelements - Al (r=0.71; p

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Association of serum copper, zinc and selenium levels with risk of metabolic syndrome: A nested case-control study of middle-aged and older Chinese adults

Cited by 33 publications

References 44 publications

Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene Polymorphism with Metabolic Syndrome and Its Components

Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene Polymorphism with Metabolic Syndrome and Its Components

Comparison of dietary micronutrient intake in PCOS patients with and without metabolic syndrome

Abnormal values of trace elements and blood metals in patients with metabolic syndrome, depending on its components

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