Association of serum concentrations of retinol and carotenoids with overweight in children and adolescents

Silva, Luciane de Souza Valente da; Veiga, Glória Valéria da; Ramalho, Rejane Andréa

doi:10.1016/j.nut.2007.02.009

Cited by 66 publications

(61 citation statements)

References 24 publications

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“…This is also reflected at the population level where higher rates of obesity are found in women rather than men (Shrimpton and Rokx, 2012). Similar findings have been shown for obese children and adolescents (de Souza et al, 2007;Garcia et al, 2013). …”

Section: The Interventionsupporting

confidence: 76%

“…It is well known that obesity is a leading cause for many non-communicable chronic diseases (NCDs) including cardiovascular disease, hypertension, type 2 diabetes (T2D) and cancer. More recently, micronutrient deficiency has been found in obese individuals in Vietnam and Latin American countries such as Mexico and Brazil (Laillou et al, 2014;Garcia et al, 2013;de Souza et al, 2007).Together, these two burdens constitute the double burden of malnutrition. There is increasing evidence indicating an inverse association between micronutrients and individuals with a higher body mass index (BMI), in particular fat soluble vitamins such as vitamin A (Andersen et al, 2006; Suzuki et al, 2006).…”

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confidence: 99%

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Protocol: The relationship between vitamin A and body mass: A systematic review and meta-analysis

Iqbal

Stewart

Mendes

et al. 2018

Preprint

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The proposed protocol is for a systematic review and meta-analysis on the relationship between vitamin A and body mass. The primary objective is to explore the mechanisms between vitamin A and adiposity such as inflammation, dietary intake and body fat. The secondary objective is to look at the extent to which vitamin A is stored in different adipose tissue depots. The protocol outlines the motive and scope for the review, and methodology including the risk of bias, statistical analysis, screening and study criteria. Background 1 The problem, condition or issueGlobally, an estimated 1.9 billion people are either overweight or obese (WHO et al, 2017). It is well known that obesity is a leading cause for many non-communicable chronic diseases (NCDs) including cardiovascular disease, hypertension, type 2 diabetes (T2D) and cancer. More recently, micronutrient deficiency has been found in obese individuals in Vietnam and Latin American countries such as Mexico and Brazil (Laillou et al, 2014;Garcia et al, 2013;de Souza et al, 2007).Together, these two burdens constitute the double burden of malnutrition. There is increasing evidence indicating an inverse association between micronutrients and individuals with a higher body mass index (BMI), in particular fat soluble vitamins such as vitamin A (Andersen et al, 2006; Suzuki et al, 2006). These studies have also shown that dietary intakes of normal weight, overweight and obese individuals are not drastically different. Moreover, animal studies confirmed that obesity causes vitamin A deficiency, as vitamin A levels and transcriptional signalling is reduced in multiple organs, when serum vitamin A concentrations are in the normal range (Trasino et al, 2015).In humans, low serum vitamin A concentrations have been observed in obese individuals, most likely due to increased uptake into the adipose tissue depot, which is acting as a major body pool for vitamin A (Osth et al, 2014;Bonet et al, 2012;Bonet et al, 2003). Although, there is considerable evidence showing similar observations for other vitamins such as vitamin D, vitamin A plays a key role in the regulation of genes involved in fatty acid oxidation and lipid metabolism (Saneei et al, 2013). Vitamin A has been shown to be associated with a reduced odds of metabolic syndrome (MS), non alcoholic fatty acid liver disease (NAFLD) and dyslipidemia (Beydoun et al, 2012;Botella-Carretero et al, 2010;Albuquerque et al, 2016). Therefore, adequate vitamin A status in key metabolic tissues may lead to favourable reductions in body fat and subsequently reductions in obesity.However, it is not clear if an increase in adiposity is a causal effect of low serum vitamin A concentrations or the result of other physiological and environmental factors (Garcia et al, 2009). For instance, inflammation and dietary intake have been implicated as reasons for reduced serum vitamin A concentrations (Hosseini et al, 2017). Therefore, the proposed review hopes to show the degree at which inflammation and dietary intake each effect seru...

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Section: The Interventionsupporting

confidence: 76%

mentioning

confidence: 99%

Protocol: The relationship between vitamin A and body mass: A systematic review and meta-analysis

Iqbal

Stewart

Mendes

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…Por outro lado, a literatura vem apontando outros grupos com potencial de risco para a deficiência da vitamina A, como os escolares e, especialmente, os adolescentes (20)(21)(22) . Na seleção dos artigos analisados, apenas Ramalho et al (15) , Da Silva et al (23) , Santos et al (24) e Graebner et al (25) incluíram escolares e adolescentes em suas casuísticas, demonstrando que, no Brasil, a deficiência da vitamina A nesses grupos etários ainda é pouco estudada. Além disso, com o crescente aumento da obesidade na infância e adolescência e sua relação com a redução dos níveis sérico de vitamina A, deve-se discutir e avaliar o estado nutricional antropométrico como variável independente para a deficiência da vitamina A (16) .…”

Section: Discussionunclassified

“…Além disso, com o crescente aumento da obesidade na infância e adolescência e sua relação com a redução dos níveis sérico de vitamina A, deve-se discutir e avaliar o estado nutricional antropométrico como variável independente para a deficiência da vitamina A (16) . Da Silva et al (23) encontraram grande risco de níveis mais baixos de carotenóides em escolares e adolescentes com sobrepeso (OR 2,51; IC95% 1,43-4,39). Diante disso, a literatura é unâni-me ao afirmar que a deficiência da vitamina A, assim como carências de outros micronutrientes, está mais associada ao consumo inadequado de alimentos fontes do que à classificação do estado nutricional antropométrico (16,26) .…”

Section: Discussionunclassified

Análise crítica de estudos brasileiros sobre deficiência de vitamina A no grupo materno-infantil

Ramalho

Padilha

Saunders

2008

Rev. paul. pediatr.

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OBJETIVO: Apresentar uma análise crítica de estudos da literatura sobre a deficiência de vitamina A (DVA) no Brasil, segundo o indicador bioquímico retinol sérico, considerando-se o impacto negativo da DVA na saúde reprodutiva e no desenvolvimento infantil. FONTES DE DADOS: os bancos de dados Medline e BVS, no período de 1994 a 2007, foram rastreados com a combinação de descritores: "vitamin A deficiency", "Brazil", "pregnant", "children" e "retinol serum level". A inclusão dos artigos foi realizada com base em critérios de elegibilidade referentes à população, desenho do estudo e idioma, enfatizando-se estudos com gestantes, puérperas, nutrizes, lactentes e pré-escolares que não apresentassem doenças crônicas não-transmissíveis ou infecciosas. SÍNTESE DOS DADOS: dos 27 artigos selecionados, 25 eram estudos transversais, um era caso-controle e um estudo longitudinal. Identificou-se que 71% e 25% dos trabalhos com gestantes e crianças, respectivamente, adotaram valores de retinol sérico <1,05µmol/L como ponto de corte. Todos os estudos apontaram a DVA como um problema de proporção preocupante. Reconhece-se a emergente inserção dos adolescentes no grupo de risco potencial para DVA e da antropometria como variável independente para tal deficiência nutricional. CONCLUSÕES: Aponta-se uma necessidade de incluir estratégias de intervenção adicionais à suplementação, reavaliar pontos de corte na interpretação do diagnóstico da DVA e refletir sobre a pertinência da inclusão de novas áreas e grupos com risco potencial para DVA em programas de intervenção.

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“…ferent routes ameliorates obesity, dyslipidemia, insulin resistance and hepatosteatosis in normal adult mice and genetic mouse models of obesity 10) . In humans, an inverse relationship has been reported between vitamin A intake and adiposity 36) , as well as an inadequate vitamin A status in overweight and obese individuals 37,38) suggesting that subclinical vitamin A deficiency is a contributing factor to obesity, fatty liver and insulin resistance.…”

Section: Conflicts Of Interestmentioning

confidence: 99%

Vitamin A-enriched Diet Modulates Reverse Cholesterol Transport in Hypercholesterolemic Obese Rats of the WNIN/Ob Strain

Anamthathmakula¹,

Jeyakumar²,

Giridharan³

et al. 2014

JAT

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Aim: Vitamin A plays a major role in lipid metabolism. Previously, we reported that chronic vitamin A feeding (129 mg/kg) for two months normalized the abnormally high plasma HDL-cholesterol (HDL-C) levels in hypercholesterolemic obese rats by upregulating the hepatic scavenger receptor class B type 1 (SR-BI) expression. In this report, we hypothesize that the administration of a dose less than 129 mg of vitamin A/kg would also be effective in lowering the plasma HDL-C levels in these rats. Methods: Changes in the activity and expression of proteins related to RCT were analyzed together with blood parameters in five-month-old male lean and obese rats supplemented with 2.6 (control group), 26, 52 and 129 mg of vitamin A/kg as retinyl palmitate for 20 weeks. Results: Vitamin A supplementation in the obese rats decreased the plasma HDL-C levels with a concomitant increase in the hepatic SR-BI expression and lipase activity compared to that observed in the control diet-fed obese rats treated with 2.6 mg of vitamin A/kg diet. Furthermore, vitamin A supplementation at doses of 52 and 129 mg/kg diet reduced the plasma lecithin cholesterol acyltransferase activity and increased the hepatic ATP-binding cassette transporter protein A1 expression in the obese rats. Interestingly, most of these changes were not observed in the lean rats fed a vitamin A-enriched diet. Conclusions: Chronic feeding of a vitamin A-enriched diet in hypercholesterolemic obese rats normalizes the plasma HDL-C level and presumably improves RCT, with an effective dose of 52 mg/kg diet. Further studies should focus on the pharmacological potential of vitamin A supplementation to correct an abnormal human obesity-associated lipoprotein metabolism.

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Association of serum concentrations of retinol and carotenoids with overweight in children and adolescents

Cited by 66 publications

References 24 publications

Protocol: The relationship between vitamin A and body mass: A systematic review and meta-analysis

Protocol: The relationship between vitamin A and body mass: A systematic review and meta-analysis

Análise crítica de estudos brasileiros sobre deficiência de vitamina A no grupo materno-infantil

Vitamin A-enriched Diet Modulates Reverse Cholesterol Transport in Hypercholesterolemic Obese Rats of the WNIN/Ob Strain

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