Association of Serum 25-Hydroxyl Vitamin D Deficiency and Age-Related Cataract: A Case-Control Study

Abdellah, Marwa Mahmoud; Mostafa, Engy Mohamed; Salama, Eman H; Mohamed, Eman

doi:10.1155/2019/9312929

Cited by 17 publications

(17 citation statements)

References 28 publications

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“…However, identifying a modifiable risk factor for cataract development would be of great value. According to the report of Abdellah et al [22], delaying cataract development is important and appropriate when the costs are considered and especially in developing countries [22]. We agree with this approach.…”

Section: Discussionsupporting

confidence: 62%

“…This may be explained by the fact that men are exposed to more sunlight as a result of their outdoor activities. Vitamin D was also found to be lower in female patients in the study of Abdellah et al [22].…”

Section: Discussionmentioning

confidence: 88%

“…The vitamin D level was lower than in the healthy control subjects in cataract patients and especially in those with a nuclear cataract. The authors interpreted this result as indicating a possible role of 25-OH vitamin D deficiency in age-related cataract [22]. Vitamin D deficiency was also found to be associated with a PSC in another study on relevant risk factors.…”

Section: Discussionmentioning

confidence: 95%

“…Abdellah et al [22] studied patients aged 50 years and over with nuclear, cortical, and subcapsular cataract. The vitamin D level was lower than in the healthy control subjects in cataract patients and especially in those with a nuclear cataract.…”

Section: Discussionmentioning

confidence: 99%

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Vitamin D Levels in Young Adult Cataract Patients: A Case-Control Study

Öktem

Aslan²

2020

Ophthalmic Res

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Objective: We aimed to investigate whether a relationship is present between early cataract formation and vitamin D in young adults. Methods: A total of 37 cataract patients (18 males and 19 females) and 53 healthy participants (27 males and 26 females) under the age of 60 years were included in this study. The 25-OH vitamin D values were measured in all subjects and the mean vitamin D levels compared between the 2 groups. Additionally, the differences between the vitamin D levels of the genders in both groups were investigated. Results: The mean age of the study group was 48.1 ± 8.5 (range 33–59) years, and the mean age of the control group was 49.3 ± 7.8 (range 31–59) years (p = 0.48 and p = 0.83). The mean vitamin D level was 15.6 ± 8.4 ng/mL in the study group and 20.8 ± 7.1 ng/mL in the healthy subjects (p = 0.002). Among the females, the vitamin D level was 10.6 ± 4.7 ng/mL in the study group and 18.1 ± 6.4 ng/mL in the control group (p = 0.0001). No significant difference was found between the groups among the males (p = 0.24). Conclusion: We found vitamin D deficiency to be associated with early age-related cataract in a statistically significant manner. We believe it is worth investigating the reason for this concurrence with large longitudinal studies.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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Vitamin D Levels in Young Adult Cataract Patients: A Case-Control Study

Öktem

Aslan²

2020

Ophthalmic Res

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“…Vitamin D multifunctional bioactivity should not be overlooked when considering the potential clinical significance of its intake in AMD. Vitamin D deficiency has also been linked to conditions associated with AMD risk, including obesity [ 47 ], myocardial infarction [ 48 ], hypertension and coronary disease [ 49 ] and cataract [ 50 ]. It is conceivable that this is reflected in the trend for deficiency (< 20 μg/L) we observed for overweight and obese subjects, and subjects with a history of hypertension, atherosclerosis, myocardial infarction and cataract surgery; however, these trends were marginal in our study, and their significance should be tested in larger populations.…”

Section: Discussionmentioning

confidence: 99%

Cross-Sectional Study on Vitamin D, Zinc Oxide and Fatty Acid Status in a Population with a Moderate to High Risk of AMD Identified by the STARS® Questionnaire

et al. 2021

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Introduction A prospective study was carried out in Belgium to determine the proportion of subjects with a moderate to high risk of developing age-related macular degeneration (AMD), identified using the STARS ® (Simplified Théa AMD Risk-Assessment Scale) questionnaire, who were in need of nutritional supplementation, by assessing the vitamin D, zinc oxide and fatty acid profile status. Methods This multicentre cross-sectional pilot study involved 50 Belgian subjects with no or early AMD, aged > 55 years who were at moderate to high risk for AMD. Subjects were assessed using the STARS ® questionnaire, visual acuity assessment, an optical coherence tomography scan of the macula and fundus photography. Blood samples were collected, and serum analyses were performed to determine the the omega-6:omega-3 (Ω6:Ω3) ratio and the levels of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), zinc and cupric oxides and vitamin D. Results Abnormal serum levels for at least one of the micronutrients was detected in 94% of the subjects. Lower than optimal vitamin D levels were found in 76% of the participants, and 68% of the subjects demonstrated at least one abnormal fatty acid profile. The Ω6:Ω3 ratio was above the reference range for normal values in 54% of the subjects; DHA and EPA levels were below the reference range in 60 and 46% of the subjects, respectively; and zinc oxide concentration was below the reference range in 50% of the subjects. Only 12% of the subjects exhibited cupric oxide deficiency. Conclusion In this study, the STARS ® questionnaire was used for early identification of patients at moderate to high risk of AMD in real life. These patients presented a suboptimal nutritional status. Further research is needed to determine if specific diet modification or micronutrient supplement intake delays the onset or slows down the progression of AMD in these subjects. Trial Registration Trial registration: ClinicalTrials.Gov, identifier: NCT04482465. Supplementary Information The online version of this article (10.1007/s40123-021-00335-4) contains supplementary material, which is available to authorized users.

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Association between vitamin D level and cataract: A systematic review and meta-analysis

Jue,

Xu,

Yuen

et al. 2024

Graefes Arch Clin Exp Ophthalmol

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Purpose The association between serum vitamin D level and cataract remains controversial. This study aims to evaluate the association between vitamin D level and cataract. Methods In this study, articles in the PubMed, Web of Science, and EMBASE databases were searched up to 30 August 2023 and 626 articles were screened. Four studies involving a total of 10,928 subjects with cataract and 10,117 control subjects met the inclusion criteria. Results Decreased serum vitamin D level was associated with higher incidence of cataract (P = 0.047; MD: -4.87; 95%CI: [-9.67, -0.07]). In the subgroup analysis by sex, a significant association was found between serum vitamin D level and cataract in both male (P = 0.01, MD: -2.15,95%CI: [-3.83, -0.46]) and female (P < 0.01; MD: -6.67,95%CI: [-8.20, -5.14]).In the subgroup analysis by the types of cataract, significant association was found between serum vitamin D level and nuclear (P < 0.01; MD: -10.48; 95%CI: [-12.72, -8.24]) and posterior subcapsular cataract (P = 0.02; MD: -6.05; 95%CI: [-11.30, -0.80]) but not in cortical cataract (P = 0.14; MD: -6.74; 95%CI: [-15.70, 2.22]). Conclusion This meta-analysis revealed potential association between serum vitamin D level and cataract, more significant in female, and the subtypes of nuclear and posterior subcapsular cataract.

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Association of Serum 25-Hydroxyl Vitamin D Deficiency and Age-Related Cataract: A Case-Control Study

Cited by 17 publications

References 28 publications

Vitamin D Levels in Young Adult Cataract Patients: A Case-Control Study

Vitamin D Levels in Young Adult Cataract Patients: A Case-Control Study

Cross-Sectional Study on Vitamin D, Zinc Oxide and Fatty Acid Status in a Population with a Moderate to High Risk of AMD Identified by the STARS® Questionnaire

Association between vitamin D level and cataract: A systematic review and meta-analysis

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