Association of serotonin gene (5-HTTLPR & 5-HTTVNTR) polymorphism with Fibromyalgia Syndrome in North Indian Women

Abstract

Background Several psychiatric disorders have been found associated with serotonin transporter gene polymorphisms. The purpose of this study was to explore the correlation between serotonin gene polymorphism (5-HTTLPR & 5-HTTVNTR) in North Indian Women with Fibromyalgia Syndrome (FMS). Results 105 FMS patients and 105 controls were enrolled in the study. Polymerase chain reaction (PCR) method was used to analyse the 5-HTTLPR & 5-HTTVNTR gene polymorphism. The psychopathology status of the 105 FMS patients and 105 healthy controls was assessed using the Beck Depression Inventory (BDI) and the Symptom Checklist-90-Revised questionnaires (SCL-90-R). Patients with psychiatric symptoms were excluded from the study. No significant differences were found in 5-HTTVNTR genotypes; 10/10 (OR 0.74, P = 1.000), 10/12 (OR 0.72, P = 0.4691) and 12/12 (OR 0.92, P = 0.3697) or 5-HTTLPR genotypes; L/L (OR 0.59, P = 0.7212), S/L (OR 1.10, P = 0.6700) and S/S (OR 0.92, P = 0.8890) between patients and controls. Conclusion Hence, we conclude that serotonin gene polymorphism (5-HTTLPR & 5-HTTVNTR) is not associated with FMS in north Indian women.