Association of SARS-CoV-2 Infection With New-Onset Type 1 Diabetes Among Pediatric Patients From 2020 to 2021

Kendall, Ellen K; Olaker, Veronica R; Kaelber, David C.; Xu, Rong; Davis, Pamela B.

doi:10.1001/jamanetworkopen.2022.33014

Cited by 87 publications

(85 citation statements)

References 5 publications

(7 reference statements)

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“… [34] Finally, in another US study, new-onset diabetes was increased in children aged 10-18 years at 3 months (HR: 2.40 (1.62-3.56)) and 6 months (HR: 2.18 (1.57-3.03), but not in children aged 0-9 years. [39] …”

Section: Resultsmentioning

confidence: 99%

The bidirectional association between diabetes and long-COVID-19 – A systematic review

Harding

Oviedo

Ali

et al. 2023

Diabetes Research and Clinical Practice

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Section: Resultsmentioning

confidence: 99%

The bidirectional association between diabetes and long-COVID-19 – A systematic review

Harding

Oviedo

Ali

et al. 2023

Diabetes Research and Clinical Practice

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“…A total of 853 studies were screened. The exclusion process yielded 8 studies 3 , 5 , 9 , 19 – 23 conducted in 3 countries. Barret et al was reported in this meta-analysis as two independent studies 3 .…”

Section: Resultsmentioning

confidence: 99%

Association of COVID-19 with diabetes: a systematic review and meta-analysis

Ssentongo

Zhang

Witmer

et al. 2022

Sci Rep

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Emerging evidence suggests that coronavirus disease-2019 (COVID-19) may lead to a wide range of post-acute sequelae outcomes, including new onset of diabetes. The aim of this meta-analysis was to estimate the incidence of newly diagnosed diabetes in survivors of COVID-19. We searched MEDLINE, Scopus, Cochrane Central Register of Controlled Trials and the World Health Organization Global Literature on Coronavirus Disease and clinical trial registries for studies reporting the association of COVID-19 and diabetes. Search dates were December 2019–October 16, 2022. Two investigators independently assessed studies for inclusion. Risk of bias was assessed using the Newcastle–Ottawa Scale. We estimated the effect of COVID-19 on incident diabetes by random-effects meta-analyses using the generic inverse variance method. We identified 8 eligible studies consisting of 4,270,747 COVID-19 patients and 43,203,759 controls. Median age was 43 years (interquartile range, IQR 35–49), and 50% were female. COVID-19 was associated with a 66% higher risk of incident diabetes (risk ratio, 1.66; 95% CI 1.38; 2.00). The risk was not modified by age, sex, or study quality. The median risk of bias assessment was 7. In this systematic review and meta-analysis, COVID-19 was associated with higher risk for developing new onset diabetes among survivors. Active monitoring of glucose dysregulation after recovery from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is warranted.

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“…The MetroHealth System, Cleveland OH, IRB determined research using TriNetX is not Human Subject Research and therefore IRB exempt. We previously used TriNetX Analytics network platform to study risk factors and outcomes of COVID-19 and other diseases [6][7][8][9][10][11][12][13][14][15][16] , including examining the incidence rates and clinical outcomes of COVID-19 with the Omicron and Delta variants in children ≤ 5 years of age 6 .…”

Section: Study Populationmentioning

confidence: 99%

Disruption in seasonality, patient characteristics and disparities of respiratory syncytial virus infection among young children in the US during and before the COVID-19 pandemic: 2010-2022

Wang

Davis

Berger

et al. 2022

Preprint

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Respiratory syncytial virus (RSV) infections and hospitalization have surged sharply among young children. Here we test how the seasonal patterns of RSV infections in 2022 compared with those from other COVID-19 pandemic and pre-pandemic years. For this purpose, we analyzed a nation-wide and real-time database of electronic health records of 56 million patients across 50 states in the US. The monthly incidence rate of first-time RSV infection in young children (<5 years of age) and very young children (<1 year of age) followed a seasonal pattern from 2010 to 2019 with increases during the autumn, peaking in winter, subsiding in spring and summer. This seasonal pattern was significantly disrupted during the COVID-19 pandemic. In 2020, the incidence rate of RSV infections was remarkably low throughout the year. In 2021, the RSV season expanded to 9 months starting in the early summer and peaking in October. In 2022, RSV infections started to rise in May and were significantly higher than in previous years reaching a historically highest incidence rate in November 2022. There were significant racial and ethnic disparities in the peak RSV infection rate during 2010-2021 and the disparities further exacerbated in 2022 with peak incidence rate in black and Hispanic children 2-3 times that in white children. Among RSV-infected children in 2022, 19.2% had prior documented COVID-19 infection, significantly higher than the 9.7% among uninfected children, suggesting that prior COVID-19 could be a risk factor for RSV infection or that there are common risk factors for both viral infections. Our study calls for continuous monitoring of RSV infection in young children alongside its clinical outcomes and for future work to assess potential COVID-19 related risk factors.

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Association of SARS-CoV-2 Infection With New-Onset Type 1 Diabetes Among Pediatric Patients From 2020 to 2021

Abstract: This cohort study assesses the association of COVID-19 with new-onset type 1 diabetes among pediatric patients.

Cited by 87 publications

References 5 publications

The bidirectional association between diabetes and long-COVID-19 – A systematic review

The bidirectional association between diabetes and long-COVID-19 – A systematic review

Association of COVID-19 with diabetes: a systematic review and meta-analysis

Disruption in seasonality, patient characteristics and disparities of respiratory syncytial virus infection among young children in the US during and before the COVID-19 pandemic: 2010-2022

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