Association of salivary steroid hormones and their ratios with time-domain heart rate variability indices in healthy individuals

Mazgelytė, Eglė; Chomentauskas, Gintaras; Dereškevičiūtė, Edita; Rekienė, Virginija; Jakaitienė, Audronė; Petrėnas, Tomas; Songailienė, Jurgita; Utkus, Algirdas; Aušrelė, Kučinskienė Zita; Karčiauskaitė, Dovilė

doi:10.5937/jomb0-26045

Cited by 10 publications

(11 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…38 The importance of both relaxation and breathing characteristics was underscored in the MYgym results, which were the best results among the urban and indoor workouts. Mazgelyte et al, 39 provided the functional connection between the described psychophysical effects and our observed results, as they found signifycant associations between diminished parasympathetic vagal tone, evaluated by time domain heart rate variability measures, higher salivary cortisol and lower levels of both DHEA-S and the DHEA-S to cortisol ratio in healthy individuals.…”

Section: Discussionsupporting

confidence: 76%

The Role of the Environment and Type of Exercise on Acute Adrenal Modulation and Perceived Distress of Breast Cancer Survivors Practising Light-Intensity Physical Exercise

et al. 2022

View full text Add to dashboard Cite

Background: Distress and adrenal balance of breast cancer survivors (BCS) are key elements of their psychophysical health, and increasing evidence has shown both physical exercise and the natural environment are effective for their modulation. The aim of the study was to evaluate the acute effects of the environment and type of light intensity workouts, on distress, salivary cortisol and dehydroepiandrosterone sulfate (DHEA-S) in BCS.Methods: Twenty-four BCS participated in six different workouts, each with the same duration and intensity. Three of them were conducted in natural environments – walking (Wnature), canoeing with assistance (Cnature) and a mix of myofascial and yoga exercises (MYnature). The others were conducted in an urban environment, namely walking (Wurban), or an indoor environment, namely mobilisation and light upper body exercises (MCgym) and a mix of myofascial and yoga exercises (MYgym). Before and after each workout, the Distress Thermometer was completed and saliva was collected.Results: Workouts practised in natural environments elicited a higher reduction in cortisol and the cortisol to DHEA-S ratio and a greater DHEA-S increase compared with workouts practised in urban and indoor environments. Overall, Cnature and MYnature were the best activities; among those practised in urban and indoor environments, MYgym elicited the best results. Distress was not acutely reduced after Wurban and MCgym. Conclusion: Natural environments seem to provide the best management of distress, cortisol, DHEA-S and their balance when working out at light intensities. The simultaneous presence of forests and rivers seems to be the key element of the observed results.

show abstract

Section: Discussionsupporting

confidence: 76%

The Role of the Environment and Type of Exercise on Acute Adrenal Modulation and Perceived Distress of Breast Cancer Survivors Practising Light-Intensity Physical Exercise

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The activity of the ANS and the HPA axis coordinated with each other in response to stress (Anderson et al, 2008;Marques et al, 2010;Mazgelytė et al, 2021). As a marker of sympathovagal balance, HRV refers to a sensitive indicator of sympathetic and vagal activity (Kayacan et al, 2021;Mazgelytė et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…Psychological stress triggers a cascade of pathophysiological events mediated by the autonomic nervous system (ANS) and the hypothalamic-pituitary-adrenal (HPA) axis (Anderson et al, 2008;Marques et al, 2010;Mazgelytė et al, 2021). These two neural stress systems coordinate the responses of many other physiological systems to stressors, including the immune and cardiovascular systems, allowing the body to return to homeostasis (Marques et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…These two neural stress systems coordinate the responses of many other physiological systems to stressors, including the immune and cardiovascular systems, allowing the body to return to homeostasis (Marques et al, 2010). Traditionally, HPA axis activity has been assessed by measuring its end-product cortisol, whereas ANS activity has been assessed by heart rate variability (HRV; Mazgelytė et al, 2021). Dysregulation of the HPA axis or ANS can significantly disrupt homeostasis, causing cacostasis or allostasis, with a range of clinical manifestations.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of psychological stress, cortisol awakening response, and heart rate variability in patients with chronic prostatitis/chronic pelvic pain syndrome complicated by lower urinary tract symptoms and erectile dysfunction

Bai

Chen

et al. 2022

Front. Psychol.

View full text Add to dashboard Cite

BackgroundMental stress and imbalance of its two neural stress systems, the autonomic nervous system (ANS) and the hypothalamic–pituitary–adrenal (HPA) axis, are associated with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and erectile dysfunction (ED). However, the comprehensive analyses of psychological stress and stress systems are under-investigated, particularly in CP/CPPS patients complicated by lower urinary tract symptoms (LUTS) and ED.Materials and methodsParticipants were 95 patients in CP/CPPS+ED group, 290 patients in CP/CPPS group, 124 patients in ED group and 52 healthy men in control group. The National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI), the International Index of Erectile Function-5 (IIEF-5) and the International Prostate Symptom Score (IPSS) were used for assessing the disease severity of CP/CPPS, LUTS and ED. Psychometric self-report questionnaires including the Beck Anxiety Inventory (BAI), Perceived Stress Scale (PSS), Type A Personality Test (TAPT) and Symptom Checklist 90 (SCL-90) were completed for distress from physical symptoms. Twenty-five subjects per group were randomly selected for further investigating the changes of the HPA axis and ANS. Saliva samples were taken on 3 consecutive days at 8 specific times with strict reference to time of morning awakening for evaluation of free cortisol. Heart rate variability (HRV) as marker of the ANS was measured using 24 h electrocardiography, and time-and frequency-domain variables were analyzed.ResultsThe BAI and SCL-90 scores were significantly higher in the CP/CPPS+ED, CP/CPPS and ED groups compared with the control group (p < 0.01). The PSS scores of both groups with ED were significantly higher than the control group (p < 0.01). Compared with the CP/CPPS group, the differences of PSS, SCL-90 and TAPT scores were statistically significant in CP/CPPS+ED patients (p < 0.01). The IPSS scores were shown to have significantly positive correlations with BAI (r = 0.32, p < 0.0001), PSS (r = 0.18, p < 0.01) and SCL-90 (r = 0.19, p < 0.01) in the CP/CPPS patients. However, in all subjects, the IIEF-5 scores were shown to have significantly negative correlations with BAI (r = −0.17，p < 0.001), PSS (r = −0.25，p < 0.0001), SCL-90 (r = −0.20，p < 0.001) and quality of life score in NIH-CPSI (r = −0.14，p = 0.0075). Cortisol awakening response (CAR) parameters and diurnal cortisol levels did not significantly vary between the four groups. Time-dependent parameters of HRV also did not differ significantly across groups. In the frequency domain analysis, low frequency (LF) was significantly lower in ED patients when compared with CP/CPPS+ED patients (p = 0.044) and healthy controls (p = 0.005), high frequency (HF) power was significantly higher in healthy controls compared to patients with ED (p < 0.001), CP/CPPS (p < 0.001) and CP/CPPS+ED (p < 0.001), and the CP/CPPS+ED group had significantly higher LF/HF ratio than the control group (p = 0.001).ConclusionCP/CPPS and ED patients score exceedingly high on most psychosocial variables. The symptom scores of LUTS and ED positively correlate with the severity of psychological stress. Our findings also suggest that the ANS sympathovagal imbalance is associated with ED and LUTS in CP/CPPS, whereas HPA axis activity is not.

show abstract

“…However, the participants were a homogeneous group with respect to age and lifestyle since all were university students. Moreover, there are a number of other studies with cortisol investigations, comprising similar or even smaller number of participants but rendering useful results and information (18,(40)(41)(42)(43)(44).…”

Section: Limitationsmentioning

confidence: 99%

Diurnal Salivary Cortisol in Relation to Body Composition and Heart Rate Variability in Young Adults

et al. 2022

View full text Add to dashboard Cite

ObjectiveChronic stress has been related to impaired body composition (bone, muscle, adipose tissue), and disturbed autonomic nervous system (ANS), the latter regulated by hypothalamic–pituitary–adrenal (HPA) axis. Our objective was to investigate the relationship between salivary cortisol, body composition and heart rate variability (HRV—highly influenced by ANS), in a young student population.MethodsBody composition and HRV parameters were measured using two portable devices based on multi-frequency bioelectrical impedance and photoplethysmography. Body composition included measurement of bone, lean/muscle and adipose tissues. HRV included time domain and frequency domain indices. Salivary cortisol, immediately after awakening, 60 min post awakening and late night was collected and analyzed by ELISA.ResultsParticipants included n = 43 healthy university students (39 women, 4 men); 21.1 ± 1.3 years, BMI = 21.8 ± 3.4 kg/m2. Skeletal muscle was reduced in most of the participants, bone mass was at the lower normal range, while the fat tissue parameters were normal with only 7% participants being overweight. Cortisol and HRV parameters of sympathetic predominance (low frequency—LF and low frequency/high frequency ratio—LF/HF) were significantly associated with higher fat tissue parameters (fat mass—FM% and intramuscular adipose tissue—IMAT%) (p <0.001 and p = 0.035, respectively) and with lower skeletal muscle (p = 0.002) and bone mass (p = 0.025).ConclusionsThe results point to a role of cortisol and ANS in the control of all three body composition compartments, suggesting that the stress can result in adverse effects on body composition, even in young, apparently healthy individuals.

show abstract

Association of salivary steroid hormones and their ratios with time-domain heart rate variability indices in healthy individuals

Cited by 10 publications

References 27 publications

The Role of the Environment and Type of Exercise on Acute Adrenal Modulation and Perceived Distress of Breast Cancer Survivors Practising Light-Intensity Physical Exercise

The Role of the Environment and Type of Exercise on Acute Adrenal Modulation and Perceived Distress of Breast Cancer Survivors Practising Light-Intensity Physical Exercise

Evaluation of psychological stress, cortisol awakening response, and heart rate variability in patients with chronic prostatitis/chronic pelvic pain syndrome complicated by lower urinary tract symptoms and erectile dysfunction

Diurnal Salivary Cortisol in Relation to Body Composition and Heart Rate Variability in Young Adults

Contact Info

Product

Resources

About