Association of salivary peroxidase activity and concentration with periodontal health: A validity study

Zahedani, Maral Memarzadeh; Schwahn, Christian; Baguhl, Romy; Kocher, Thomas; Below, Harald; Welk, Alexander

doi:10.1111/jcpe.12754

Cited by 3 publications

(3 citation statements)

References 60 publications

(84 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the administration of an efficient lactoperoxidase system in a toothpaste also containing lactoferrin and lysozyme may prevent oral dysbiosis ( 145 ). A few studies have demonstrated an inverse association between the activity of sialoperoxidase and the depth of the periodontal pockets ( 146 ). On the other hand, the administration of inactive peroxidase without substrate seems to disturb in vitro the balance between commensals and periodontopathogens to the latter's advantage ( 98 , 147 ).…”

Section: Mimicking Biological Systemsmentioning

confidence: 99%

Oral peroxidases: From antimicrobial agents to ecological actors (Review)

Courtois

2021

Mol Med Rep

View full text Add to dashboard Cite

Sialoperoxidase and myeloperoxidase are the two main peroxidase enzymes found in the oral cavity. Sialoperoxidase is present in salivary secretions and in the biofilms that line the oral surfaces, while myeloperoxidase is abundant in the dento-gingival sulcus area. In the presence of hydrogen peroxide (H 2 O 2 ), oral peroxidases catalyze the oxidation of the pseudohalide anion thiocyanate (SCN − ) to hypothiocyanite (OSCN − ), a strong oxidant that serves an antimicrobial role. Furthermore, oral peroxidases consume bacteria-produced H 2 O 2 and could help inactivate toxic carcinogenic and genotoxic substances. Numerous in vitro studies have reported the antibacterial, antimycotic and antiviral role of peroxidases, suggesting possible applications in oral therapy. However, the use of oral hygiene products incorporating peroxidase systems has not yet been shown to be beneficial for the treatment or prevention of oral infections. This paradox reflects our incomplete knowledge of the physiological role of peroxidases in a complex environment, such as the oral region. While hygiene is crucial for restoring oral microbiota to a symbiotic state, there are no data to suggest that the addition of a peroxidase per se can create a dysbiotic state. Recent investigations have associated the presence of peroxidase activity with gram-positive cocci microbial flora, and its insufficiency with dysbiosis has been linked to pathologies, such as caries, periodontitis or infections of the oral mucosa. Therefore, oxidants generated by oral peroxidases appear to be an essential ecological determinant for oral health through the selection of a symbiotic microbiota capable of resisting oxidative stress. The objective of the present review was to update the current knowledge of the physiological aspects and applications of oral peroxidases in clinical practice.

show abstract

Section: Mimicking Biological Systemsmentioning

confidence: 99%

Oral peroxidases: From antimicrobial agents to ecological actors (Review)

Courtois

2021

Mol Med Rep

View full text Add to dashboard Cite

show abstract

“…Salvolini et al showed that the highest concentrations of LPO in saliva are met in a group of healthy individuals aged 10–24, then its concentration decreases with age [36]. Changes in the secretion of LPO due to the circadian cycle have also been identified, with the highest concentration occurring around noon [37], which may be associated with increased physical activity [38]. During exercise, it comes to the formation of superoxide anion radical in the mitochondria of skeletal and cardiac muscles, which is then spontaneously or catalytically (with superoxide dismutase) converted to H 2 O 2 .…”

Section: Secretion In Physiological and Pathological Conditionsmentioning

confidence: 99%

“…Numerous studies are conducted in search of a connection between the occurrence of certain oral conditions and changes in the LPO synthesis. A decrease in its concentration has been reported in periodontitis (28 juvenile patients; 46 subjects, 25–54 years) [37,56] in contrast to patients with both type 1 diabetes and periodontitis (10 patients) who demonstrated an increase in LPO activity which may be associated with co-occurring xerostomia and production of concentrated saliva [57,58]. Other studies have shown no significant associations between the occurrence or severity of periodontitis and LPO salivary concentration [59,60].…”

Section: Secretion In Physiological and Pathological Conditionsmentioning

confidence: 99%

The Significance of Lactoperoxidase System in Oral Health: Application and Efficacy in Oral Hygiene Products

Magacz

Kędziora

Sapa

et al. 2019

IJMS

View full text Add to dashboard Cite

Lactoperoxidase (LPO) present in saliva are an important element of the nonspecific immune response involved in maintaining oral health. The main role of this enzyme is to oxidize salivary thiocyanate ions (SCN−) in the presence of hydrogen peroxide (H2O2) to products that exhibit antimicrobial activity. LPO derived from bovine milk has found an application in food, cosmetics, and medical industries due to its structural and functional similarity to the human enzyme. Oral hygiene products enriched with the LPO system constitute an alternative to the classic fluoride caries prophylaxis. This review describes the physiological role of human salivary lactoperoxidase and compares the results of clinical trials and in vitro studies of LPO alone and complex dentifrices enriched with bovine LPO. The role of reactivators and inhibitors of LPO is discussed together with the possibility of using nanoparticles to increase the stabilization and activity of this enzyme.

show abstract